Cyp51 (cytochrome P450, family 51) - Rat Genome Database

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Gene: Cyp51 (cytochrome P450, family 51) Rattus norvegicus
Analyze
Symbol: Cyp51
Name: cytochrome P450, family 51
RGD ID: 2481
Description: Enables sterol 14-demethylase activity. Involved in several processes, including cholesterol biosynthetic process via 24,25-dihydrolanosterol; positive regulation of oocyte development; and response to human chorionic gonadotropin. Located in acrosomal vesicle. Biomarker of diabetes mellitus. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp51a1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; LDM; MGC93630; P450-14DM; P45014DM; P450LI; RATCP14DM; sterol 14-alpha demethylase; sterol 14-alpha demethylase P450
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,991,693 - 31,010,147 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl430,991,613 - 31,010,450 (+)EnsemblGRCr8
mRatBN7.2430,036,956 - 30,055,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl676,725,868 - 76,727,458 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx435,009,705 - 35,028,159 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,935,797 - 30,954,251 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,331,773 - 29,350,227 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)Ensemblrn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera425,462,810 - 25,481,264 (+)NCBICelera
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Cytogenetic Map4q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bifonazole  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bitertanol  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cerium trichloride  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
difenoconazole  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
diuron  (EXP)
econazole  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (ISO)
ergosterol  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP,ISO)
fipronil  (ISO)
fluconazole  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
flutriafol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hexaconazole  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
lanosterol  (EXP,ISO)
lead nitrate  (EXP,ISO)
leflunomide  (EXP,ISO)
letrozole  (ISO)
levofloxacin  (EXP)
limonene  (EXP)
lithocholic acid  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N(6)-butyryl-cAMP  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
obeticholic acid  (ISO)
organophosphorus compound  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
Pf-06840003  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylpropanolamine  (ISO)
phosgene  (ISO)
phytosterols  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
prothioconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
ritodrine  (ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
voriconazole  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver. Aoyama Y, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1320-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
4. Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. Keber R, etal., J Biol Chem. 2011 Aug 19;286(33):29086-97. doi: 10.1074/jbc.M111.253245. Epub 2011 Jun 25.
5. Altered gene expression of hepatic lanosterol 14alpha-demethylase (CYP51) in lead nitrate-treated rats. Kojima M, etal., Arch Toxicol. 2002 Jul;76(7):398-403. doi: 10.1007/s00204-002-0365-3. Epub 2002 Jun 18.
6. Lanosterol 14alpha-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase in spermatogenesis: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol. Majdic G, etal., J Endocrinol. 2000 Aug;166(2):463-74. doi: 10.1677/joe.0.1660463.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Cloning and functional expression of the cDNA encoding rat lanosterol 14-alpha demethylase. Sloane DL, etal., Gene 1995 Aug 19;161(2):243-8.
15. Lanosterol 14 alpha-demethylase (cytochrome P-45014DM): modulation of its enzyme activity by cholesterol feeding. Sonoda Y, etal., Biol Pharm Bull. 1995 Jul;18(7):1009-11.
16. Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats. Strömstedt M, etal., Endocrinology. 1998 May;139(5):2314-21. doi: 10.1210/endo.139.5.5984.
17. Role of meiosis-activating sterols in rat oocyte maturation: effects of specific inhibitors and changes in the expression of lanosterol 14alpha-demethylase during the preovulatory period. Vaknin KM, etal., Biol Reprod. 2001 Jan;64(1):299-309. doi: 10.1095/biolreprod64.1.299.
18. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
19. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
20. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
21. Insulin is the essential factor maintaining the constitutive expression of hepatic sterol 14-demethylase P450 (CYP51). Yamashita C, etal., J Biochem. 2000 Jul;128(1):93-9. doi: 10.1093/oxfordjournals.jbchem.a022734.
22. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.
Additional References at PubMed
PMID:9498553   PMID:12477932   PMID:15269103   PMID:15489334   PMID:19946888   PMID:20149798   PMID:20876579   PMID:22871113   PMID:31352176  


Genomics

Comparative Map Data
Cyp51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,991,693 - 31,010,147 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl430,991,613 - 31,010,450 (+)EnsemblGRCr8
mRatBN7.2430,036,956 - 30,055,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl676,725,868 - 76,727,458 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx435,009,705 - 35,028,159 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,935,797 - 30,954,251 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,331,773 - 29,350,227 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)Ensemblrn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera425,462,810 - 25,481,264 (+)NCBICelera
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Cytogenetic Map4q13NCBI
CYP51A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,112,153 - 92,134,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,084,987 - 92,134,803 (-)Ensemblhg38GRCh38
GRCh37791,741,467 - 91,764,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,579,402 - 91,601,946 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34791,386,116 - 91,408,661NCBI
Celera786,446,011 - 86,468,618 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,348,902 - 86,371,499 (-)NCBIHuRef
CHM1_1791,671,533 - 91,694,128 (-)NCBICHM1_1
T2T-CHM13v2.0793,353,434 - 93,376,082 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,070,701 - 91,093,297 (-)NCBI
Cyp51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,130,674 - 4,154,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,131,145 - 4,154,746 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3854,080,674 - 4,104,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)Ensemblmm10GRCm38
MGSCv3754,080,674 - 4,104,697 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3654,086,680 - 4,110,703 (-)NCBIMGSCv36mm8
Celera54,010,747 - 4,034,762 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.3NCBI
LOC102027002
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,092,933 - 9,112,615 (-)Ensembl
ChiLan1.0NW_0049554329,092,923 - 9,112,615 (-)NCBIChiLan1.0ChiLan1.0
CYP51A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26109,998,616 - 110,022,815 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,262,334 - 158,287,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,110,130 - 84,132,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1797,708,806 - 97,730,486 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,708,806 - 97,729,824 (-)EnsemblpanPan2panpan1.1
CYP51A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,746,654 - 17,767,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,550,375 - 17,573,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101955024
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,136,259 - 31,159,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,209,199 - 2,232,531 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,209,255 - 2,232,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP51A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,057,511 - 72,079,444 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1972,057,506 - 72,079,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,792,905 - 78,814,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP51A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,865,498 - 56,888,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,865,312 - 56,886,698 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604247,377,473 - 47,400,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101724157
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248091,080,656 - 1,100,254 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248091,080,427 - 1,110,802 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116904123
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16136,371,225 - 136,389,383 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp51
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000009985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42228845340471598Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42228845345429897Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RH128867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,055,191 - 30,055,378 (+)MAPPERmRatBN7.2
Rnor_6.0427,193,800 - 27,193,986NCBIRnor6.0
Rnor_5.0427,097,026 - 27,097,212UniSTSRnor5.0
RGSC_v3.4426,770,913 - 26,771,099UniSTSRGSC3.4
Celera425,481,046 - 25,481,232UniSTS
RH 3.4 Map4168.4UniSTS
Cytogenetic Map4q13UniSTS
RH129291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,055,200 - 30,055,383 (+)MAPPERmRatBN7.2
Rnor_6.0427,193,809 - 27,193,991NCBIRnor6.0
Rnor_5.0427,097,035 - 27,097,217UniSTSRnor5.0
RGSC_v3.4426,770,922 - 26,771,104UniSTSRGSC3.4
Celera425,481,055 - 25,481,237UniSTS
RH 3.4 Map4168.4UniSTS
Cytogenetic Map4q13UniSTS
RH137266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,054,687 - 30,054,868 (+)MAPPERmRatBN7.2
Rnor_6.0427,193,296 - 27,193,476NCBIRnor6.0
Rnor_5.0427,096,522 - 27,096,702UniSTSRnor5.0
RGSC_v3.4426,770,409 - 26,770,589UniSTSRGSC3.4
Celera425,480,542 - 25,480,722UniSTS
RH 3.4 Map9723.0UniSTS
Cytogenetic Map4q13UniSTS
RH141214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,054,313 - 30,054,493 (+)MAPPERmRatBN7.2
Rnor_6.0427,192,922 - 27,193,101NCBIRnor6.0
Rnor_5.0427,096,148 - 27,096,327UniSTSRnor5.0
RGSC_v3.4426,770,035 - 26,770,214UniSTSRGSC3.4
Celera425,480,168 - 25,480,347UniSTS
RH 3.4 Map6547.8UniSTS
Cytogenetic Map4q13UniSTS
UniSTS:256608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2676,726,278 - 76,726,909 (+)MAPPERmRatBN7.2
Rnor_6.0680,127,507 - 80,128,137NCBIRnor6.0
Rnor_5.0689,653,379 - 89,654,009UniSTSRnor5.0
RGSC_v3.4679,727,169 - 79,727,799UniSTSRGSC3.4
Celera675,486,561 - 75,487,191UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map4q13UniSTS
Cyp51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2676,727,021 - 76,727,338 (+)MAPPERmRatBN7.2
Rnor_6.0680,128,250 - 80,128,566NCBIRnor6.0
Rnor_5.0689,654,122 - 89,654,438UniSTSRnor5.0
RGSC_v3.4679,727,912 - 79,728,228UniSTSRGSC3.4
Celera675,487,304 - 75,487,620UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map4q13UniSTS


Related Rat Strains
The following Strains have been annotated to Cyp51
BB/OK    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009985   ⟹   ENSRNOP00000009985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl430,991,613 - 31,010,450 (+)Ensembl
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)Ensembl
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103698   ⟹   ENSRNOP00000095201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl676,725,868 - 76,727,458 (-)Ensembl
RefSeq Acc Id: NM_012941   ⟹   NP_037073
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8430,991,693 - 31,010,147 (+)NCBI
mRatBN7.2430,036,956 - 30,055,410 (+)NCBI
Rnor_6.0427,175,564 - 27,194,018 (+)NCBI
Rnor_5.0427,078,790 - 27,097,244 (+)NCBI
RGSC_v3.4426,752,677 - 26,771,131 (+)RGD
Celera425,462,810 - 25,481,264 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037073 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA87074 (Get FASTA)   NCBI Sequence Viewer  
  AAH87033 (Get FASTA)   NCBI Sequence Viewer  
  BAA09529 (Get FASTA)   NCBI Sequence Viewer  
  BAA20354 (Get FASTA)   NCBI Sequence Viewer  
  EDL84353 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009985
  ENSRNOP00000009985.3
GenBank Protein Q64654 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037073   ⟸   NM_012941
- UniProtKB: Q64549 (UniProtKB/Swiss-Prot),   Q64654 (UniProtKB/Swiss-Prot),   A6K271 (UniProtKB/TrEMBL),   A0A8I6AJ77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009985   ⟸   ENSRNOT00000009985
Ensembl Acc Id: ENSRNOP00000095201   ⟸   ENSRNOT00000103698

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64654-F1-model_v2 AlphaFold Q64654 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692842
Promoter ID:EPDNEW_R3366
Type:initiation region
Name:Cyp51_1
Description:cytochrome P450, family 51
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0427,175,501 - 27,175,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2481 AgrOrtholog
BioCyc Gene G2FUF-45773 BioCyc
Ensembl Genes ENSRNOG00000007234 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000065555 Ensembl
Ensembl Transcript ENSRNOT00000009985 ENTREZGENE
  ENSRNOT00000009985.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130609 IMAGE-MGC_LOAD
InterPro CYP450_sterol_14alpha_dmase UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25427 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93630 IMAGE-MGC_LOAD
NCBI Gene 25427 ENTREZGENE
PANTHER 24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp51 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007234 RatGTEx
  ENSRNOG00000065555 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I6AJ77 ENTREZGENE
  A6K271 ENTREZGENE, UniProtKB/TrEMBL
  CP51A_RAT UniProtKB/Swiss-Prot
  Q64549 ENTREZGENE
  Q64654 ENTREZGENE
UniProt Secondary Q64549 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp51  cytochrome P450, family 51  Cyp51  cytochrome P450, subfamily 51  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp51  cytochrome P450, subfamily 51     Cytochrom P450 Lanosterol 14 alpha-demethylase  Name updated 625702 APPROVED
2002-06-10 Cyp51  Cytochrom P450 Lanosterol 14 alpha-demethylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70557