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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2481
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp51
Name: cytochrome P450, family 51
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp51decreases expressionISOCYP51A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CYP51A1 mRNAPMID:21632981 PMID:26238291 PMID:32234424
Cyp51decreases expressionISOCyp51 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CYP51 mRNAPMID:19770486 PMID:22228805
Cyp51decreases methylationISOCYP51A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CYP51A1 5' UTR; Benzo(a)pyrene results in decreased methylation of CYP51A1 promoterPMID:27901495
Cyp51increases expressionISOCyp51 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CYP51A1 mRNA; Benzo(a)pyrene results in increased expression of CYP51A1 proteinPMID:20127859 PMID:34472326
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