Cyp51 (cytochrome P450, family 51) - Rat Genome Database

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Gene: Cyp51 (cytochrome P450, family 51) Mus musculus
Analyze
Symbol: Cyp51
Name: cytochrome P450, family 51
RGD ID: 70832
MGI Page MGI
Description: Predicted to enable heme binding activity and sterol 14-demethylase activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Predicted to be located in acrosomal vesicle. Is expressed in several structures, including early conceptus; genitourinary system; integumental system; jaw; and nervous system. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI426508; Cyp51a1; CYPLI; cytochrome P450 51A1; cytochrome P450, 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; Ldm; P450-14DM; P450LI; sterol 14-alpha demethylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,130,674 - 4,154,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,131,145 - 4,154,746 (-)EnsemblGRCm39 Ensembl
GRCm3854,080,674 - 4,104,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,080,674 - 4,104,697 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3654,086,680 - 4,110,703 (-)NCBIMGSCv36mm8
Celera54,010,747 - 4,034,762 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP,ISO)
acetamide  (ISO)
acetohydrazide  (EXP)
Acetyl tributyl citrate  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-phellandrene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bifonazole  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bitertanol  (ISO)
bromobenzene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (EXP)
cerium trichloride  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (EXP)
diclofenac  (EXP)
Dicyclohexyl phthalate  (ISO)
difenoconazole  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
diquat  (EXP)
diuron  (ISO)
econazole  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
ergosterol  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP,ISO)
fipronil  (ISO)
fluconazole  (ISO)
fluoranthene  (EXP)
flusilazole  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
hexaconazole  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
lanosterol  (ISO)
lead nitrate  (EXP,ISO)
leflunomide  (ISO)
letrozole  (ISO)
levofloxacin  (ISO)
limonene  (ISO)
lithocholic acid  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N(6)-butyryl-cAMP  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
obeticholic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
phosgene  (EXP)
phytosterols  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
prothioconazole  (EXP)
pyrazinecarboxamide  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
ritodrine  (EXP)
ritonavir  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tebuconazole  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
toluene  (ISO)
tremolite asbestos  (EXP)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
voriconazole  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. Keber R, etal., J Biol Chem. 2011 Aug 19;286(33):29086-97. doi: 10.1074/jbc.M111.253245. Epub 2011 Jun 25.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Lanosterol 14 alpha-demethylase (cytochrome P-45014DM): modulation of its enzyme activity by cholesterol feeding. Sonoda Y, etal., Biol Pharm Bull. 1995 Jul;18(7):1009-11.
11. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
12. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
13. Insulin is the essential factor maintaining the constitutive expression of hepatic sterol 14-demethylase P450 (CYP51). Yamashita C, etal., J Biochem. 2000 Jul;128(1):93-9. doi: 10.1093/oxfordjournals.jbchem.a022734.
14. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.
Additional References at PubMed
PMID:2644625   PMID:3304292   PMID:3542713   PMID:8889548   PMID:9052933   PMID:10349636   PMID:10551787   PMID:10653123   PMID:10864439   PMID:11042159   PMID:11076861   PMID:11988326  
PMID:12464255   PMID:12477932   PMID:12745259   PMID:14500367   PMID:14630712   PMID:14681479   PMID:15782199   PMID:16123160   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18287559  
PMID:18520052   PMID:18775413   PMID:18937335   PMID:18973680   PMID:19007561   PMID:19334288   PMID:19433477   PMID:19633360   PMID:19793088   PMID:20876579   PMID:21267068   PMID:21305474  
PMID:21677750   PMID:21873635   PMID:22111624   PMID:23509403   PMID:25393872   PMID:25651181   PMID:25739789   PMID:26108225   PMID:27008858   PMID:28031458   PMID:28098217   PMID:28658622  
PMID:28938463   PMID:30420384   PMID:32554809   PMID:33182326   PMID:34822715  


Genomics

Comparative Map Data
Cyp51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,130,674 - 4,154,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,131,145 - 4,154,746 (-)EnsemblGRCm39 Ensembl
GRCm3854,080,674 - 4,104,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,080,674 - 4,104,697 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3654,086,680 - 4,110,703 (-)NCBIMGSCv36mm8
Celera54,010,747 - 4,034,762 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.3NCBI
CYP51A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,112,153 - 92,134,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,084,987 - 92,134,803 (-)EnsemblGRCh38hg38GRCh38
GRCh37791,741,467 - 91,764,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,579,402 - 91,601,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 34791,386,116 - 91,408,661NCBI
Celera786,446,011 - 86,468,618 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,348,902 - 86,371,499 (-)NCBIHuRef
CHM1_1791,671,533 - 91,694,128 (-)NCBICHM1_1
T2T-CHM13v2.0793,353,434 - 93,376,082 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,070,701 - 91,093,297 (-)NCBI
Cyp51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,991,693 - 31,010,147 (+)NCBIGRCr8
mRatBN7.2430,036,956 - 30,055,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,009,705 - 35,028,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,935,797 - 30,954,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,331,773 - 29,350,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
LOC102027002
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,092,933 - 9,112,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,092,923 - 9,112,615 (-)NCBIChiLan1.0ChiLan1.0
CYP51A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26109,998,616 - 110,022,815 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,262,334 - 158,287,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,110,130 - 84,132,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1797,708,806 - 97,730,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,708,806 - 97,729,824 (-)Ensemblpanpan1.1panPan2
CYP51A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,746,654 - 17,767,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,550,375 - 17,573,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBIUU_Cfam_GSD_1.0
LOC101955024
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,136,259 - 31,159,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,209,199 - 2,232,531 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,209,255 - 2,232,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP51A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,057,511 - 72,079,444 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,057,506 - 72,079,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,792,905 - 78,814,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP51A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,865,498 - 56,888,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,865,312 - 56,886,698 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,377,473 - 47,400,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101724157
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248091,080,656 - 1,100,254 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248091,080,427 - 1,110,802 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp51
808 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:920
Count of miRNA genes:548
Interacting mature miRNAs:681
Transcripts:ENSMUST00000001507, ENSMUST00000129448, ENSMUST00000151539
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141234Pbwg14_mpostnatal body weight growth 14 (mouse)Not determined5121273552Mouse
1301468Eye1_meye weight 1 (mouse)Not determined5121929650Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123606323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129421124Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
12738412Lfibq4_mliver fibrosis QTL 4 (mouse)5315000020799180Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse

Markers in Region
AI426508  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,082,197 - 4,082,335UniSTSGRCm38
MGSCv3754,082,197 - 4,082,335UniSTSGRCm37
Celera54,012,270 - 4,012,408UniSTS
Cytogenetic Map5A2UniSTS
cM Map51.2UniSTS
Whitehead/MRC_RH590.9UniSTS
Cyp51  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2UniSTS
cM Map51.2UniSTS
cM Map5 UniSTS
Cyp51  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2UniSTS
Cyp51  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2UniSTS
cM Map5 UniSTS
Cyp51  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC064793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC068609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF166266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB524876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001507   ⟹   ENSMUSP00000001507
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl54,131,145 - 4,154,746 (-)Ensembl
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129448
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl54,133,280 - 4,154,343 (-)Ensembl
GRCm38.p6 Ensembl54,083,280 - 4,104,343 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl54,149,276 - 4,153,381 (-)Ensembl
GRCm38.p6 Ensembl54,099,276 - 4,103,381 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl54,151,049 - 4,154,421 (-)Ensembl
GRCm38.p6 Ensembl54,101,049 - 4,104,421 (-)Ensembl
RefSeq Acc Id: NM_020010   ⟹   NP_064394
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3954,130,674 - 4,154,697 (-)NCBI
GRCm3854,080,674 - 4,104,697 (-)ENTREZGENE
MGSCv3754,080,674 - 4,104,697 (-)RGD
Celera54,010,747 - 4,034,762 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_064394   ⟸   NM_020010
- UniProtKB: Q9JIP8 (UniProtKB/Swiss-Prot),   Q8BSQ7 (UniProtKB/Swiss-Prot),   Q9JIY3 (UniProtKB/Swiss-Prot),   Q8K0C4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000001507   ⟸   ENSMUST00000001507

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K0C4-F1-model_v2 AlphaFold Q8K0C4 1-503 view protein structure

Promoters
RGD ID:6837330
Promoter ID:MM_KWN:41282
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Kidney
Transcripts:OTTMUST00000054507
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3654,103,099 - 4,103,599 (-)MPROMDB
RGD ID:6837329
Promoter ID:MM_KWN:41283
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000054505,   OTTMUST00000054506
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3654,104,256 - 4,105,537 (-)MPROMDB
RGD ID:6885918
Promoter ID:EPDNEW_M6409
Type:initiation region
Name:Cyp51_1
Description:Mus musculus cytochrome P450, family 51 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6410  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3854,104,404 - 4,104,464EPDNEW
RGD ID:6885920
Promoter ID:EPDNEW_M6410
Type:initiation region
Name:Cyp51_2
Description:Mus musculus cytochrome P450, family 51 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6409  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3854,104,759 - 4,104,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106040 AgrOrtholog
Ensembl Genes ENSMUSG00000001467 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001507 ENTREZGENE
  ENSMUST00000001507.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13121 UniProtKB/Swiss-Prot
MGD MGI:106040 ENTREZGENE
NCBI Gene 13121 ENTREZGENE
PANTHER 24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp51 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP51A_MOUSE UniProtKB/Swiss-Prot
  Q8BSQ7 ENTREZGENE
  Q8K0C4 ENTREZGENE
  Q9CW87_MOUSE UniProtKB/TrEMBL
  Q9JIP8 ENTREZGENE
  Q9JIY3 ENTREZGENE
UniProt Secondary Q8BSQ7 UniProtKB/Swiss-Prot
  Q9JIP8 UniProtKB/Swiss-Prot
  Q9JIY3 UniProtKB/Swiss-Prot