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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2481
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp51
Name: cytochrome P450, family 51
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp51affects expressionISOCyp51 (Mus musculus)6480464CTDpirinixic acid affects the expression of CYP51 mRNAPMID:19136022
Cyp51decreases expressionISOCyp51 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of CYP51 mRNAPMID:18445702
Cyp51increases expressionISOCyp51 (Mus musculus)6480464CTDpirinixic acid results in increased expression of CYP51 mRNA; pirinixic acid results in increased expression of CYP51A1 mRNAPMID:17950772 PMID:18467677 PMID:20813756 PMID:20936131
Cyp51multiple interactionsISOCyp51 (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYP51 mRNA; PPARA protein promotes the reaction [pirinixic acid results in increased expression of CYP51 mRNA]; PPARA protein promotes the reaction [pirinixic acid results in increased expression of CYP51A1 mRNA]PMID:17950772 PMID:18467677 PMID:19710929
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