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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2481
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp51
Name: cytochrome P450, family 51
Acc ID: CHEBI:94366
Term: 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one
Definition: A piperazine that has formula C35H38Cl2N8O4.
Chemical ID: MESH:D017964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp51decreases activityISOCYP51A1 (Homo sapiens)6480464CTDItraconazole results in decreased activity of CYP51A1 proteinPMID:16989930
Cyp51decreases response to substanceISOCYP51A1 (Homo sapiens)6480464CTDCYP51A1 gene results in decreased susceptibility to ItraconazolePMID:18694951
Cyp51multiple interactionsISOCYP51A1 (Homo sapiens)6480464CTDCYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]PMID:18694951
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