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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2481
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp51
Name: cytochrome P450, family 51
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp51increases activityEXP 6480464CTDKetoconazole results in increased activity of CYP51 proteinPMID:12617470
Cyp51increases expressionEXP 6480464CTDKetoconazole results in increased expression of CYP51 mRNAPMID:28263823
Cyp51multiple interactionsEXP 6480464CTD[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of LanosterolPMID:12617470
Cyp51decreases activityISOCYP51A1 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of CYP51A1 proteinPMID:16989930
Cyp51decreases response to substanceISOCYP51A1 (Homo sapiens)6480464CTDCYP51A1 gene results in decreased susceptibility to KetoconazolePMID:18694951
Cyp51increases expressionISOCyp51 (Mus musculus)6480464CTDKetoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 proteinPMID:17966066 PMID:29337257
Cyp51multiple interactionsISOCYP51A1 (Homo sapiens)6480464CTDCYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]PMID:18694951
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