Crkl (CRK like proto-oncogene, adaptor protein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Crkl (CRK like proto-oncogene, adaptor protein) Rattus norvegicus
Analyze
Symbol: Crkl
Name: CRK like proto-oncogene, adaptor protein
RGD ID: 1308531
Description: Predicted to enable several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of skeletal muscle acetylcholine-gated channel clustering; positive regulation of substrate adhesion-dependent cell spreading; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and nervous system development. Predicted to be located in synapse. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and neuromuscular junction. Predicted to be extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: crk-like protein; crk-like protein-like; LOC100911248; LOC287942; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,033,033 - 97,067,457 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,024,782 - 97,067,457 (-)EnsemblGRCr8
mRatBN7.21183,528,788 - 83,563,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,526,530 - 83,563,238 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,256,298 - 92,290,727 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,917,451 - 84,951,879 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,971,055 - 84,005,485 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,338,606 - 87,356,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,778,312 - 87,815,043 (-)Ensemblrn6Rnor6.0
Rnor_5.01190,397,653 - 90,408,448 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,520,244 - 85,554,667 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,297,248 - 82,331,672 (-)NCBICelera
RGSC_v3.11185,560,841 - 85,595,264 (-)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
nickel atom  (ISO)
nilotinib  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sorafenib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
activation of GTPase activity  (ISO)
animal organ morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
B cell apoptotic process  (ISO)
biological_process  (ND)
blood vessel development  (ISO)
cell chemotaxis  (ISO)
cell migration  (IBA)
cellular response to growth factor stimulus  (IEA)
cellular response to interleukin-7  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebellar neuron development  (ISO)
cerebral cortex development  (ISO)
chordate pharynx development  (ISO)
cranial skeletal system development  (ISO)
dendrite development  (ISO)
endothelin receptor signaling pathway  (ISO)
enzyme-linked receptor protein signaling pathway  (IBA,ISO)
establishment of cell polarity  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
heart development  (ISO)
helper T cell diapedesis  (ISO)
hippocampus development  (ISO)
intracellular signal transduction  (IEA)
lipid metabolic process  (ISO)
male gonad development  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of SMAD protein signal transduction  (IEA,ISO)
neuron migration  (ISO)
outflow tract morphogenesis  (ISO)
parathyroid gland development  (ISO)
pattern specification process  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO)
positive regulation of glial cell migration  (IEA,ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
postsynaptic specialization assembly  (ISO)
reelin-mediated signaling pathway  (ISO)
regulation of cell adhesion  (IEA)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of cell growth  (ISO)
regulation of cell migration  (IEA)
regulation of dendrite development  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of immune system process  (IEA)
regulation of leukocyte migration  (ISO)
regulation of Rac protein signal transduction  (IEA)
regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
regulation of T cell migration  (ISO)
response to fibroblast growth factor  (ISO)
retinoic acid receptor signaling pathway  (ISO)
single fertilization  (ISO)
spermatogenesis  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
urogenital system development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy. Jilani I, etal., Leuk Res. 2008 Apr;32(4):643-9. doi: 10.1016/j.leukres.2007.08.009. Epub 2007 Sep 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells. Rhodes J, etal., Exp Hematol. 2000 Mar;28(3):305-10.
13. Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition. Singer CF, etal., Oncol Rep. 2006 Feb;15(2):353-9.
14. Overexpression of CRKL correlates with malignant cell proliferation in breast cancer. Zhao T, etal., Tumour Biol. 2013 Oct;34(5):2891-7. doi: 10.1007/s13277-013-0851-7. Epub 2013 May 19.
Additional References at PubMed
PMID:9710592   PMID:11242111   PMID:12477932   PMID:16284401   PMID:16399079   PMID:16399080   PMID:17161365   PMID:17394141   PMID:18305217   PMID:18477607   PMID:19004829   PMID:19074029  
PMID:19168626   PMID:19307307   PMID:20624904   PMID:21041412   PMID:22658674   PMID:23376485   PMID:23959425   PMID:25468996   PMID:25540073   PMID:25565927   PMID:25621495   PMID:25658046  
PMID:26527617   PMID:28439006   PMID:29581031  


Genomics

Comparative Map Data
Crkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,033,033 - 97,067,457 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,024,782 - 97,067,457 (-)EnsemblGRCr8
mRatBN7.21183,528,788 - 83,563,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,526,530 - 83,563,238 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,256,298 - 92,290,727 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,917,451 - 84,951,879 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,971,055 - 84,005,485 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,338,606 - 87,356,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,778,312 - 87,815,043 (-)Ensemblrn6Rnor6.0
Rnor_5.01190,397,653 - 90,408,448 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,520,244 - 85,554,667 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,297,248 - 82,331,672 (-)NCBICelera
RGSC_v3.11185,560,841 - 85,595,264 (-)NCBI
Cytogenetic Map11q23NCBI
CRKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,917,407 - 20,953,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,917,407 - 20,953,747 (+)Ensemblhg38GRCh38
GRCh372221,271,695 - 21,308,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,601,714 - 19,637,890 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342219,596,267 - 19,632,443NCBI
Celera224,763,059 - 4,799,374 (+)NCBICelera
Cytogenetic Map22q11.21ENTREZGENE
HuRef224,539,711 - 4,576,600 (+)NCBIHuRef
CHM1_12221,271,912 - 21,308,243 (+)NCBICHM1_1
T2T-CHM13v2.02221,326,128 - 21,362,450 (+)NCBIT2T-CHM13v2.0
Crkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,269,849 - 17,305,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,269,851 - 17,305,298 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381617,451,985 - 17,487,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,451,987 - 17,487,434 (+)Ensemblmm10GRCm38
MGSCv371617,452,080 - 17,486,348 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361617,365,550 - 17,399,818 (+)NCBIMGSCv36mm8
Celera1618,025,071 - 18,059,338 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.82NCBI
Crkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,358,081 - 19,388,815 (-)Ensembl
ChiLan1.0NW_00495544219,358,202 - 19,388,552 (-)NCBIChiLan1.0ChiLan1.0
CRKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,622,858 - 30,660,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,172,806 - 33,209,143 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,141,147 - 3,177,448 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,632,359 - 19,668,858 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,632,359 - 19,668,858 (+)EnsemblpanPan2panpan1.1
CRKL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,542,276 - 30,582,479 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,545,311 - 30,581,964 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2630,499,506 - 30,540,212 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02631,950,077 - 31,990,503 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,950,075 - 31,990,495 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,995,836 - 30,036,268 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,619,771 - 29,660,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,708,885 - 30,749,836 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,267,911 - 140,306,379 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,447,614 - 2,479,805 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,447,686 - 2,479,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,528,955 - 50,558,662 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11450,528,950 - 50,558,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,977,699 - 54,007,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRKL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,855,633 - 4,889,674 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,855,611 - 4,890,302 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660852,080,371 - 2,099,812 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945734,532 - 767,168 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624945734,532 - 767,184 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Crkl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v142,701,785 - 2,738,464 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:132
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000002552
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat

Markers in Region
RH132604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,529,687 - 83,529,878 (-)MAPPERmRatBN7.2
mRatBN7.21183,529,687 - 83,529,878 (+)MAPPERmRatBN7.2
Rnor_6.01187,781,496 - 87,781,686NCBIRnor6.0
Rnor_6.01187,355,554 - 87,355,744NCBIRnor6.0
Rnor_5.01190,407,358 - 90,407,548UniSTSRnor5.0
Rnor_5.01190,833,905 - 90,834,095UniSTSRnor5.0
RGSC_v3.41185,521,144 - 85,521,334UniSTSRGSC3.4
Celera1182,298,148 - 82,298,338UniSTS
RH 3.4 Map11714.5UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 24 79 34 30 18 73 18 6 196 119 11 66 46 51 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002552   ⟹   ENSRNOP00000002552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,024,782 - 97,067,457 (-)Ensembl
mRatBN7.2 Ensembl1183,526,530 - 83,563,181 (-)Ensembl
Rnor_6.0 Ensembl1187,778,312 - 87,815,043 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115018   ⟹   ENSRNOP00000096058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,033,036 - 97,067,457 (-)Ensembl
mRatBN7.2 Ensembl1183,528,831 - 83,563,238 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154754   ⟹   ENSRNOP00000112802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,033,530 - 97,067,174 (-)Ensembl
RefSeq Acc Id: NM_001008284   ⟹   NP_001008285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,033,033 - 97,067,457 (-)NCBI
mRatBN7.21183,528,788 - 83,563,214 (-)NCBI
Rnor_6.01187,338,606 - 87,356,644 (+)NCBI
Rnor_5.01190,397,653 - 90,408,448 (+)NCBI
RGSC_v3.41185,520,244 - 85,554,667 (-)RGD
Celera1182,297,248 - 82,331,672 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85865 (Get FASTA)   NCBI Sequence Viewer  
  EDL77890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002552.4
  ENSRNOP00000096058
GenBank Protein Q5U2U2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008285   ⟸   NM_001008284
- UniProtKB: Q5U2U2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002552   ⟸   ENSRNOT00000002552
Ensembl Acc Id: ENSRNOP00000096058   ⟸   ENSRNOT00000115018
Ensembl Acc Id: ENSRNOP00000112802   ⟸   ENSRNOT00000154754
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2U2-F1-model_v2 AlphaFold Q5U2U2 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308531 AgrOrtholog
BioCyc Gene G2FUF-20589 BioCyc
Ensembl Genes ENSRNOG00000001868 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002552.6 UniProtKB/Swiss-Prot
  ENSRNOT00000115018 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190712 IMAGE-MGC_LOAD
InterPro CRK_SH3_C UniProtKB/Swiss-Prot
  CRK_SH3_N UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Tyrosine-phos_adapter UniProtKB/Swiss-Prot
KEGG Report rno:287942 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94609 IMAGE-MGC_LOAD
NCBI Gene 287942 ENTREZGENE
PANTHER CRK-LIKE PROTEIN UniProtKB/Swiss-Prot
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Crkl PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001868 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A8I6AL21_RAT UniProtKB/TrEMBL
  CRKL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Crkl  CRK like proto-oncogene, adaptor protein  LOC100911248  crk-like protein-like  Data merged from RGD:6493647 737654 PROVISIONAL
2016-06-22 Crkl  CRK like proto-oncogene, adaptor protein  Crkl  v-crk avian sarcoma virus CT10 oncogene homolog-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Crkl  v-crk avian sarcoma virus CT10 oncogene homolog-like  Crkl  v-crk sarcoma virus CT10 oncogene homolog (avian)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911248  crk-like protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Crkl  v-crk sarcoma virus CT10 oncogene homolog (avian)-like  Crkl_predicted  v-crk sarcoma virus CT10 oncogene homolog (avian)-like (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Crkl_predicted  v-crk sarcoma virus CT10 oncogene homolog (avian)-like (predicted)      Symbol and Name status set to approved 70820 APPROVED