Pias1 (protein inhibitor of activated STAT, 1) - Rat Genome Database

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Gene: Pias1 (protein inhibitor of activated STAT, 1) Rattus norvegicus
Analyze
Symbol: Pias1
Name: protein inhibitor of activated STAT, 1
RGD ID: 1307843
Description: Enables protein domain specific binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of macromolecule metabolic process; and visual learning. Predicted to be located in PML body and nuclear periphery. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of focal segmental glomerulosclerosis. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1); PARTICIPATES IN aldosterone signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; Hedgehog signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 SUMO-protein ligase PIAS1; LOC300772; protein inhibitor of activated STAT 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8872,233,566 - 72,347,085 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl872,233,566 - 72,334,315 (-)EnsemblGRCr8
mRatBN7.2863,338,150 - 63,451,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,338,150 - 63,438,905 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx868,853,069 - 68,953,867 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,125,523 - 67,226,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0864,995,537 - 65,096,314 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0867,771,720 - 67,869,015 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,771,720 - 67,869,019 (-)Ensemblrn6Rnor6.0
Rnor_5.0867,500,467 - 67,597,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4867,025,248 - 67,123,016 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera862,756,508 - 62,854,013 (-)NCBICelera
RGSC_v3.1867,044,301 - 67,142,058 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
colforsin daropate hydrochloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
dorsomorphin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP,ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (EXP)
rifampicin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
glutamatergic synapse  (IEA,ISO)
nuclear periphery  (IEA,ISO)
nuclear speck  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
PML body  (IEA,ISO)
postsynaptic cytosol  (IEA,ISO)
presynaptic cytosol  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. Belaguli NS, etal., PLoS One. 2012;7(10):e48019. doi: 10.1371/journal.pone.0048019. Epub 2012 Oct 31.
2. SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway. Chen P, etal., Int J Mol Med. 2010 Oct;26(4):619-26.
3. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. Chen YC, etal., J Neurosci. 2014 Jul 16;34(29):9574-89. doi: 10.1523/JNEUROSCI.4302-13.2014.
4. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. Kadare G, etal., J Biol Chem. 2003 Nov 28;278(48):47434-40. Epub 2003 Sep 18.
8. PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins. Kawai-Kowase K, etal., Mol Cell Biol. 2005 Sep;25(18):8009-23.
9. Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. Kurihara I, etal., J Biol Chem. 2005 Feb 25;280(8):6721-30. Epub 2004 Dec 16.
10. Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis. Liang Y, etal., Pediatr Nephrol. 2009 Sep;24(9):1661-71. doi: 10.1007/s00467-009-1163-4. Epub 2009 Apr 7.
11. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. Rabellino A, etal., Cancer Res. 2012 May 1;72(9):2275-84. doi: 10.1158/0008-5472.CAN-11-3159. Epub 2012 Mar 9.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. Tang Z, etal., J Biol Chem. 2005 Nov 18;280(46):38153-9. Epub 2005 Sep 6.
18. Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats. Tsai MC, etal., J Pineal Res. 2011 Sep;51(2):233-45. doi: 10.1111/j.1600-079X.2011.00885.x. Epub 2011 May 4.
19. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
20. Inhibitors of cytokine signal transduction. Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.
21. Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat. Yan W, etal., Gene Expr Patterns. 2003 Jun;3(3):301-8.
22. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:12356736   PMID:14752048   PMID:15572666   PMID:16127449   PMID:16522640   PMID:16816390   PMID:17087506   PMID:17283066   PMID:17696781   PMID:18555800   PMID:18579533   PMID:19744555  
PMID:20016603   PMID:20209145   PMID:20471636   PMID:21288202   PMID:21419645   PMID:21965678   PMID:22982248   PMID:24061474  


Genomics

Comparative Map Data
Pias1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8872,233,566 - 72,347,085 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl872,233,566 - 72,334,315 (-)EnsemblGRCr8
mRatBN7.2863,338,150 - 63,451,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,338,150 - 63,438,905 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx868,853,069 - 68,953,867 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,125,523 - 67,226,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0864,995,537 - 65,096,314 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0867,771,720 - 67,869,015 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,771,720 - 67,869,019 (-)Ensemblrn6Rnor6.0
Rnor_5.0867,500,467 - 67,597,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4867,025,248 - 67,123,016 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera862,756,508 - 62,854,013 (-)NCBICelera
RGSC_v3.1867,044,301 - 67,142,058 (-)NCBI
Cytogenetic Map8q24NCBI
PIAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381568,054,315 - 68,193,847 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1568,054,301 - 68,198,603 (+)Ensemblhg38GRCh38
GRCh371568,346,653 - 68,486,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,133,626 - 66,267,467 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341566,133,625 - 66,267,456NCBI
Celera1545,234,605 - 45,365,328 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1545,180,222 - 45,311,150 (+)NCBIHuRef
CHM1_11568,465,362 - 68,598,367 (+)NCBICHM1_1
T2T-CHM13v2.01565,875,930 - 66,012,597 (+)NCBIT2T-CHM13v2.0
Pias1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39962,785,648 - 62,888,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl962,785,650 - 62,895,206 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38962,878,366 - 62,980,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,878,368 - 62,987,924 (-)Ensemblmm10GRCm38
MGSCv37962,727,884 - 62,828,686 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36962,678,083 - 62,778,885 (-)NCBIMGSCv36mm8
Celera960,099,154 - 60,199,601 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map933.91NCBI
Pias1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554507,896,741 - 7,991,027 (-)Ensembl
ChiLan1.0NW_0049554507,896,741 - 7,991,045 (-)NCBIChiLan1.0ChiLan1.0
PIAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21657,310,791 - 57,445,115 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11561,484,619 - 61,618,957 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01547,006,718 - 47,141,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11565,276,530 - 65,410,105 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1565,276,530 - 65,410,105 (+)EnsemblpanPan2panpan1.1
PIAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13032,116,363 - 32,232,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3032,119,311 - 32,228,945 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3032,050,874 - 32,167,015 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03032,312,019 - 32,428,219 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3032,314,211 - 32,424,739 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13032,240,403 - 32,356,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03032,302,308 - 32,418,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03032,548,145 - 32,664,285 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pias1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640110,076,935 - 110,207,569 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,925,153 - 28,055,632 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,925,153 - 28,055,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1165,957,132 - 166,087,239 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11165,957,114 - 166,087,242 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21183,734,088 - 183,951,464 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12615,294,296 - 15,432,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2615,297,934 - 15,432,659 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048126,035,605 - 126,174,441 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pias1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247814,893,308 - 5,046,582 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247814,893,308 - 5,046,928 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pias1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1857,171,731 - 57,268,595 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pias1
476 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:133
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000066009
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
BE097511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,398,745 - 63,398,909 (+)MAPPERmRatBN7.2
Rnor_6.0867,828,868 - 67,829,031NCBIRnor6.0
Rnor_5.0867,557,615 - 67,557,778UniSTSRnor5.0
RGSC_v3.4867,082,400 - 67,082,563UniSTSRGSC3.4
Celera862,813,661 - 62,813,824UniSTS
RH 3.4 Map8788.4UniSTS
Cytogenetic Map8q24UniSTS
AI179763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,405,614 - 63,405,764 (+)MAPPERmRatBN7.2
Rnor_6.0867,835,737 - 67,835,886NCBIRnor6.0
Rnor_5.0867,564,484 - 67,564,633UniSTSRnor5.0
RGSC_v3.4867,089,269 - 67,089,418UniSTSRGSC3.4
Celera862,820,530 - 62,820,679UniSTS
RH 3.4 Map8790.6UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066009   ⟹   ENSRNOP00000059152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl863,341,822 - 63,411,842 (-)Ensembl
Rnor_6.0 Ensembl867,771,720 - 67,869,019 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097366   ⟹   ENSRNOP00000077365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl872,239,102 - 72,334,315 (-)Ensembl
mRatBN7.2 Ensembl863,343,686 - 63,438,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100439   ⟹   ENSRNOP00000093422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl872,233,566 - 72,334,311 (-)Ensembl
mRatBN7.2 Ensembl863,338,150 - 63,438,894 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105202   ⟹   ENSRNOP00000093933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl863,338,150 - 63,415,004 (-)Ensembl
RefSeq Acc Id: NM_001106829   ⟹   NP_001100299
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,334,311 (-)NCBI
mRatBN7.2863,338,150 - 63,438,894 (-)NCBI
Rnor_6.0867,771,720 - 67,869,015 (-)NCBI
Rnor_5.0867,500,467 - 67,597,762 (-)NCBI
RGSC_v3.4867,025,248 - 67,123,016 (-)RGD
Celera862,756,508 - 62,854,013 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081107   ⟹   XP_038937035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,309,637 (-)NCBI
mRatBN7.2863,338,150 - 63,413,132 (-)NCBI
RefSeq Acc Id: XM_039081109   ⟹   XP_038937037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,347,085 (-)NCBI
mRatBN7.2863,338,150 - 63,451,670 (-)NCBI
RefSeq Acc Id: XM_039081110   ⟹   XP_038937038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,334,424 (-)NCBI
mRatBN7.2863,338,150 - 63,438,998 (-)NCBI
RefSeq Acc Id: XM_039081111   ⟹   XP_038937039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,333,900 (-)NCBI
mRatBN7.2863,338,150 - 63,438,474 (-)NCBI
RefSeq Acc Id: XM_063265153   ⟹   XP_063121223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,333,529 (-)NCBI
RefSeq Acc Id: XM_063265154   ⟹   XP_063121224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,333,529 (-)NCBI
RefSeq Acc Id: XM_063265155   ⟹   XP_063121225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,233,566 - 72,333,798 (-)NCBI
RefSeq Acc Id: NP_001100299   ⟸   NM_001106829
- UniProtKB: A0A8I6AIY4 (UniProtKB/TrEMBL),   A6J591 (UniProtKB/TrEMBL),   A9UK05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059152   ⟸   ENSRNOT00000066009
RefSeq Acc Id: XP_038937037   ⟸   XM_039081109
- Peptide Label: isoform X1
- UniProtKB: A9UK05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937038   ⟸   XM_039081110
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y680 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937039   ⟸   XM_039081111
- Peptide Label: isoform X1
- UniProtKB: A9UK05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937035   ⟸   XM_039081107
- Peptide Label: isoform X1
- UniProtKB: A9UK05 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093422   ⟸   ENSRNOT00000100439
Ensembl Acc Id: ENSRNOP00000077365   ⟸   ENSRNOT00000097366
Ensembl Acc Id: ENSRNOP00000093933   ⟸   ENSRNOT00000105202
RefSeq Acc Id: XP_063121225   ⟸   XM_063265155
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y680 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121224   ⟸   XM_063265154
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y680 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121223   ⟸   XM_063265153
- Peptide Label: isoform X1
- UniProtKB: A9UK05 (UniProtKB/TrEMBL)
Protein Domains
PINIT   SAP   SP-RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9T0-F1-model_v2 AlphaFold G3V9T0 1-651 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696057
Promoter ID:EPDNEW_R6582
Type:multiple initiation site
Name:Pias1_1
Description:protein inhibitor of activated STAT, 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0867,869,015 - 67,869,075EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307843 AgrOrtholog
BioCyc Gene G2FUF-30146 BioCyc
Ensembl Genes ENSRNOG00000034272 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097366 ENTREZGENE
  ENSRNOT00000097366.2 UniProtKB/TrEMBL
  ENSRNOT00000100439 ENTREZGENE
  ENSRNOT00000100439.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  2.60.120.780 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro PINIT UniProtKB/TrEMBL
  PINIT_sf UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
  Znf_MIZ UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:300772 UniProtKB/TrEMBL
NCBI Gene 300772 ENTREZGENE
PANTHER PTHR10782:SF11 UniProtKB/TrEMBL
  ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam PINIT UniProtKB/TrEMBL
  zf-MIZ UniProtKB/TrEMBL
PhenoGen Pias1 PhenoGen
PROSITE PINIT UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
  ZF_SP_RING UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034272 RatGTEx
SMART SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt A0A8I5Y680 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIY4 ENTREZGENE, UniProtKB/TrEMBL
  A6J591 ENTREZGENE, UniProtKB/TrEMBL
  A9UK05 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-06 Pias1  protein inhibitor of activated STAT, 1  Pias1  protein inhibitor of activated STAT 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pias1  protein inhibitor of activated STAT 1   Pias1_predicted  protein inhibitor of activated STAT 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pias1_predicted  protein inhibitor of activated STAT 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED