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Pathways
Genes search result for Rattus norvegicus
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61 records found for search term Numb
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
620107NumbNUMB, endocytic adaptor proteinENCODES a protein that exhibits alpha-catenin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN positive regulation of dendrite morphogenesis; regulation of neuron differentiation; regulation of postsynapse assembly; PARTICIPATES IN altered Notch signaling6109162499109284527Rat151symbol , old_gene_name , PhenoGen , namegene, protein-coding, VALIDATED [RefSeq]
1308159Lnx1ligand of numb-protein X 1ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN synapse maturation (ortholog); ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCI143386851733971217Rat115old_gene_name , namegene, protein-coding, PROVISIONAL [RefSeq]
1308222Lnx2ligand of numb-protein X 2ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN neural precursor cell proliferation (ortholog); neuron differentiation (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8121311913913184401Rat82old_gene_name , namegene, protein-coding, PROVISIONAL [RefSeq]
1307579NumblNUMB-like, endocytic adaptor proteinINVOLVED IN positive regulation of dendrite morphogenesis; regulation of postsynapse assembly; adherens junction organization (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN glutamatergic synapse; cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenz19167743791701415Rat96symbol , old_gene_name , PhenoGen , namegene, protein-coding, VALIDATED [RefSeq]
1560628Duoxa2dual oxidase maturation factor 2ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN hydrogen peroxide biosynthetic process (ortholog); hydrogen peroxide metabolic process (ortholog); intracellular protein localization (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); familial thyroid dyshormonoge3129698938129702656Rat69old_gene_namegene, protein-coding, VALIDATED [RefSeq]
621466Il2rginterleukin 2 receptor subunit gammaENCODES a protein that exhibits coreceptor activity (ortholog); interleukin-15 receptor activity (ortholog); interleukin-2 binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular homeostasis (ortholog); interleukin-15-mediated signaling pathway (orthX7043534070439052Rat156descriptiongene, protein-coding, PROVISIONAL [RefSeq]
13628731Il2rgem1Anginterleukin 2 receptor subunit gamma;TALEN induced mutant1, AngASSOCIATED WITH decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; decreased CD8-positive, alpha-beta T cell number; ASSOCIATED WITH Immune Deficiency DRat10descriptiongene, allele
619790Rag1recombination activating 1ENCODES a protein that exhibits endonuclease activity (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN regulation of behavioral fear response; visual learning; adaptive immune response (ortholog); PARTICIPATES IN primary immunodeficiency pathway; ASSOCIATED W3108372087108383184Rat222descriptiongene, protein-coding, PROVISIONAL [RefSeq]
7204135Rag1em1Angrecombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio AnegonASSOCIATED WITH decreased B cell number; decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; ASSOCIATED WITH Immune Deficiency Disease; severe combined iRat15descriptiongene, allele
620062Pon1paraoxonase 1ENCODES a protein that exhibits aryldialkylphosphatase activity; acyl-L-homoserine-lactone lactonohydrolase activity (ortholog); arylesterase activity (ortholog); INVOLVED IN response to fatty acid; response to fluoride; response to lipopolysaccharide; PARTICIPATES IN clopidogrel pharmacodynamics pa43426131234292327Rat683descriptiongene, protein-coding, VALIDATED [RefSeq]
124715481Pon1em1Lizhparaoxonase 1; CRISPR/Cas9 induced mutant 1, LizhASSOCIATED WITH arrested T cell differentiation; decreased B cell number; decreased T cell numberRat9descriptiongene, allele
4139865Rag1em1Mcwirecombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of WisconsinASSOCIATED WITH decreased B cell number; decreased T cell number; decreased thymus weight; ASSOCIATED WITH Albuminuria; Hypertensive NephropathyRat7descriptiongene, allele
7204132Rag1em1Ztmrecombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule HannoverASSOCIATED WITH decreased B cell number; decreased T cell number; small thymus; ASSOCIATED WITH severe combined immunodeficiencyRat4descriptiongene, allele
5509982Sh2b3em2McwiSH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of WisconsinASSOCIATED WITH decreased heart ventricle muscle contractility; increased lymphocyte cell number; increased monocyte cell number; ASSOCIATED WITH Myocardial Reperfusion InjuryRat5descriptiongene, allele
1311139Aireautoimmune regulatorENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN central tolerance induction to self antigen (ortholog); humoral immune response (ortholog); negative thymic T cell selection (ortholog); PARTICIPATES IN primary201063577510650709Rat129descriptiongene, protein-coding, VALIDATED [RefSeq]
38599148Aireem1Angautoimmune regulator; ZFN induced mutant1, AngASSOCIATED WITH abnormal NK cell number; abnormal thymus morphology; alopecia; ASSOCIATED WITH autoimmune polyendocrine syndromeRat10descriptiongene, allele
1306571Arsgarylsulfatase GENCODES a protein that exhibits arylsulfatase activity (ortholog); N-sulfoglucosamine-3-sulfatase activity (ortholog); INVOLVED IN gene expression (ortholog); glial cell differentiation (ortholog); homeostasis of number of cells (ortholog); ASSOCIATED WITH autis109491209495063021Rat127descriptiongene, protein-coding, VALIDATED [RefSeq]
1306637Atxn2ataxin 2ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN cerebellar Purkinje cell differentiation (ortholog); homeostasis of number of cells (ortholog); negative regulation of multicellular organism growth (ortholog); ASSO124041365740509895Rat127descriptiongene, protein-coding, VALIDATED [RefSeq]
2305Cd247Cd247 moleculeENCODES a protein that exhibits identical protein binding (ortholog); MHC class II receptor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell surface receptor signaling pathway; Fc-gamma receptor signaling pathway (ortholog); positive regulation of protein localiz138057626480651422Rat149descriptiongene, protein-coding, VALIDATED [RefSeq]
5687703Cd247em1McwiCd247 molecule; zinc finger nuclease induced mutant 1, Medical College of WisconsinASSOCIATED WITH absent alpha-beta T cells; decreased B cell number; decreased mean systemic arterial blood pressureRat9descriptiongene, allele
13792720Cd59em1AskCD59 molecule; CRISPR/Cas9 induced mutant1, AskASSOCIATED WITH decreased erythrocyte cell number; increased red blood cell distribution width; increased susceptibility to type III hypersensitivity reaction; ASSOCIATED WITH neuromyelitis opticaRat5descriptiongene, allele
2311Cd59bCD59b moleculeENCODES a protein that exhibits complement binding; protein sequestering activity (ortholog); INVOLVED IN negative regulation of activation of membrane attack complex; negative regulation of apoptotic process; negative regulation of complement-dependent cytotoxicity; PARTICIPATES IN coagulation casc3110914008110932489Rat218descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1310015Cd7Cd7 moleculeENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); positive regulation of T cell cytokine production (ortholog); ASSOCIATED WITH amyotrophic lateral scleros10106802373106805269Rat61descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1592336Clpsl2colipase-like 2ENCODES a protein that exhibits enzyme activator activity (inferred); INVOLVED IN acrosome reaction (ortholog); homeostasis of number of cells (ortholog); single fertilization (ortholog); FOUND IN acrosomal vesicle (ortholog); sperm flagellum (ortholog); INTERAC2066098326612655Rat21descriptiongene, protein-coding, VALIDATED [RefSeq]
1305806Col14a1collagen type XIV alpha 1 chainINVOLVED IN collagen fibril organization (ortholog); homeostasis of number of cells within a tissue (ortholog); regulation of cell growth involved in cardiac muscle cell development (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH Chemical78861182788826939Rat154descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1310332Cyfip1cytoplasmic FMR1 interacting protein 1ENCODES a protein that exhibits RNA 7-methylguanosine cap binding; small GTPase binding (ortholog); translation repressor activity (ortholog); INVOLVED IN cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; positive regulation of axon extension; PARTICIPATES IN 1115842754115935163Rat149descriptiongene, protein-coding, PROVISIONAL [RefSeq]
14985211Cyfip1em1Sagecytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, SageASSOCIATED WITH abnormal brain white matter morphology; decreased myelin sheath thickness; decreased oligodendrocyte numberRat3descriptiongene, allele
2323810Cylc1cylicin 1ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN acrosome assembly (ortholog); cell morphogenesis (ortholog); maintenance of cell number (ortholog); ASSOCIATED WITH male infertility (ortholog); X-linked spermatogenic failX8022428880313698Rat36descriptiongene, protein-coding, VALIDATED [RefSeq]
1562799Cylc2cylicin 2ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog57034979170384673Rat22descriptiongene, protein-coding, VALIDATED [RefSeq]
2314903F8m1Ycbcoagulation factor VIII, procoagulant component; mutation 1, YcbASSOCIATED WITH decreased erythrocyte cell number; decreased hematocrit; decreased hemoglobin content; ASSOCIATED WITH factor VIII deficiencyRat4descriptiongene, allele
1561045FanceFA complementation group EINVOLVED IN gene expression (ortholog); homeostasis of number of cells (ortholog); ovarian follicle development (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colon carcinoma (ortholog); F2063711536388366Rat81descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1563891Gcnt4glucosaminyl (N-acetyl) transferase 4ENCODES a protein that exhibits glycosyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN homeostasis of number of cells (ortholog); inter-male aggressive behavior (ortholog); kidney morphogenesis (ortholog); FOUND IN Golgi apparatus 22998794430017708Rat59descriptiongene, protein-coding, VALIDATED [RefSeq]
2318130Gigyf2GRB10 interacting GYF protein 2ENCODES a protein that exhibits molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); feeding behavior (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WI99544914395574927Rat138descriptiongene, protein-coding, VALIDATED [RefSeq]
15004087Ighmimmunoglobulin heavy constant epsilonINVOLVED IN immune system process (inferred); PARTICIPATES IN allograft rejection pathway; ASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiency; FOUND IN immunoglobulin complex (inferred)Rat12descriptiongene, protein-coding
150523756Ighmem1Angimmunoglobulin heavy constant mu; ZFN induced mutant1, AngASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiencyRat7descriptiongene, allele
150523758Ighmem2Angimmunoglobulin heavy constant mu; ZFN induced mutant2, AngASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiencyRat7descriptiongene, allele
2887Il15interleukin 15ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cellular response to vitamin D; hyaluronan metabolic process; negative regulation of smooth muscle cell proliferation; PARTICIPATES IN Jak-Stat signaling pathway; cytokine mediated signaling pathway; rheumatoid arthritis pathw194253616042611349Rat298descriptiongene, protein-coding, VALIDATED [RefSeq]
12910491Il15em1Soarinterleukin 15; ZFN induced mutant 1, SoarASSOCIATED WITH abnormal placenta junctional zone morphology; abnormal uterine spiral artery morphology; decreased NK cell numberRat4descriptiongene, allele
1566151Il20rbinterleukin 20 receptor subunit betaENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); PARTICIPA8109858108109896066Rat106descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1596420Ildr2immunoglobulin-like domain containing receptor 2INVOLVED IN cell differentiation (ortholog); homeostasis of number of cells within a tissue (ortholog); insulin secretion (ortholog); FOUND IN tight junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol138105172381113590Rat97descriptiongene, protein-coding, MODEL [RefSeq]
708458Jmjd1cjumonji domain containing 1CENCODES a protein that exhibits histone H3K9 demethylase activity (ortholog); protein demethylase activity (ortholog); INVOLVED IN epithelial cell morphogenesis (ortholog); lipid biosynthetic process (ortholog); maintenance of cell number (ortholog); PARTICIPATE202133099021508580Rat146descriptiongene, protein-coding, PROVISIONAL [RefSeq]
621446Klf5KLF transcription factor 5ENCODES a protein that exhibits sequence-specific DNA binding; transcription factor binding; DNA binding (ortholog); INVOLVED IN cellular response to endothelin; positive regulation of cell population proliferation; angiogenesis (ortholog); ASSOCIATED WITH abnormal postsynaptic density morphology; a158247208182487267Rat303descriptiongene, protein-coding, VALIDATED [RefSeq]
1303290Klhl10kelch-like family member 10INVOLVED IN cell morphogenesis (ortholog); fertilization (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH spermatogenic failure 11 (ortholog); spermatogenic failure 3 (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH108587680485893081Rat44descriptiongene, protein-coding, PROVISIONAL [RefSeq]
620802Latlinker for activation of T cellsENCODES a protein that exhibits molecular condensate scaffold activity (ortholog); protein kinase binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); gene expression (ortholog); homeostasis of number of c1190367111190372515Rat141descriptiongene, protein-coding, PROVISIONAL [RefSeq]
3000LepleptinENCODES a protein that exhibits hormone activity; peptide hormone receptor binding; signaling receptor binding; INVOLVED IN bone mineralization involved in bone maturation; cardiac muscle hypertrophy; cellular response to L-ascorbic acid; PARTICIPATES IN energy homeostasis pathway; leptin system pat45862652958640663Rat1063descriptiongene, protein-coding, VALIDATED [RefSeq]
12904927Lepem1Sageleptin; zinc finger nuclease induced mutant1, SageASSOCIATED WITH abnormal interferon level; decreased T cell number; increased body weight; ASSOCIATED WITH glucose intolerance; Hypercholesterolemia; hyperinsulinismRat11descriptiongene, allele
1303311Lrrc46leucine rich repeat containing 46INVOLVED IN axoneme assembly (ortholog); maintenance of cell number (ortholog); single fertilization (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN sperm flagellum (ortholog); sperm midpiece (ortholog); INTERACTS WITH 17alpha-ethynylestradiol108251776782530011Rat48descriptiongene, protein-coding, PROVISIONAL [RefSeq]
2325346Mir195microRNA 195ENCODES an ncrna that exhibits lncRNA binding (ortholog); mRNA 3'-UTR binding (ortholog); mRNA base-pairing post-transcriptional repressor activity (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); long-term synaptic potentiation (ortholog); miRNA-mediated gene silencing by 105545049555450581Rat81descriptiongene, ncrna, PROVISIONAL [RefSeq]
69406Pclopiccolo (presynaptic cytomatrix protein)ENCODES a protein that exhibits calcium ion binding; calcium-dependent phospholipid binding; transcription corepressor binding; INVOLVED IN modulation of excitatory postsynaptic potential; positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; ASSOCIATED WITH abnormal c42064660421005171Rat177descriptiongene, protein-coding, VALIDATED [RefSeq]
41408340PcloTn(sb-B-Geo)Fkhpresynaptic cytomatrix protein; sleeping beauty transposon induced mutant, FkhASSOCIATED WITH abnormal cerebellar glomerulus morphology; abnormal synaptic vesicle number; abnormal synaptic vesicle recyclingRat11descriptiongene, allele
628752Rab38RAB38, member RAS oncogene familyENCODES a protein that exhibits GTP binding; AP-1 adaptor complex binding (ortholog); AP-2 adaptor complex binding (ortholog); INVOLVED IN platelet dense granule organization; positive regulation of melanin biosynthetic process; positive regulation of phosphatidylcholine biosynthetic process; ASSOCI1151595153151675492Rat172descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1600311Rab38ruRab38, member of RAS oncogene family, ruby alleleASSOCIATED WITH abnormal coat/hair pigmentation; abnormal platelet dense granule number; abnormal surfactant secretion; ASSOCIATED WITH Hermansky-Pudlak syndromeRat7descriptiongene, allele
1305588Rag2recombination activating 2ENCODES a protein that exhibits chromatin binding (ortholog); histone H3K4me3 reader activity (ortholog); phosphatidylinositol binding (ortholog); INVOLVED IN mature B cell differentiation involved in immune response; negative regulation of T cell differentiation in thymus; B cell differentiation (o3108357399108367186Rat106descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1305551Rassf2Ras association domain family member 2ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN bone remodeling (ortholog); canonical NF-kappaB signal transduction (ortholog); homeostasis of number of cells (ortholog); ASSOCIATED WITH Lymphatic Metastasis (ortholog); Nasopharyn3139697187139733402Rat146descriptiongene, protein-coding, VALIDATED [RefSeq]
1311646Sart3spliceosome associated factor 3, U4/U6 recycling proteinENCODES a protein that exhibits histone binding (ortholog); protein-macromolecule adaptor activity (ortholog); U4 snRNA binding (ortholog); INVOLVED IN cell morphogenesis (ortholog); hematopoietic stem cell proliferation (ortholog); homeostasis of number of cell124851957948547584Rat141descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1560293Sash3SAM and SH3 domain containing 3INVOLVED IN homeostasis of number of cells within a tissue (ortholog); positive regulation of adaptive immune response (ortholog); positive regulation of B cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 1X132204717132219421Rat88descriptiongene, protein-coding, PROVISIONAL [RefSeq]
4139858Sh2b3em1McwiSH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of WisconsinASSOCIATED WITH decreased susceptibility to hypertension; decreased urine albumin level; increased regulatory T cell number; ASSOCIATED WITH Albuminuria; hypertensionRat5descriptiongene, allele
1311266Tex15testis expressed 15, meiosis and synapsis associatedINVOLVED IN DNA methylation-dependent constitutive heterochromatin formation (ortholog); fertilization (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH myoepithelioma (ortholog); spermatogenic failure 1 (ortholog); spermatog166530204965362065Rat93descriptiongene, protein-coding, VALIDATED [RefSeq]
1564531Trpv3transient receptor potential cation channel, subfamily V, member 3ENCODES a protein that exhibits calcium channel activity (ortholog); identical protein binding (ortholog); monoatomic cation channel activity (ortholog); INVOLVED IN positive regulation of calcium ion import; negative regulation of hair cycle (ortholog); response to temperature stimulus (ortholog); 105838205458413657Rat165descriptiongene, protein-coding, VALIDATED [RefSeq]
1564601Vpreb1bV-set pre-B cell surrogate light chain 1BINVOLVED IN B cell proliferation (ortholog); cell morphogenesis (ortholog); homeostasis of number of cells (ortholog); INTERACTS WITH bisphenol A; furan; indole-3-methanol119651369496514404Rat20descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1562664Zfxzinc finger protein X-linkedENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN fertilization (ortholog); germ cell development (ortholog); homeostasis of numbX6279848362847068Rat103descriptiongene, protein-coding, VALIDATED [RefSeq]