| 620107 | Numb | NUMB, endocytic adaptor protein | ENCODES a protein that exhibits alpha-catenin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN positive regulation of dendrite morphogenesis; regulation of neuron differentiation; regulation of postsynapse assembly; PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving the macromolecules modifying the main players; Notch signaling pathway; FOUND IN apical part of cell; dendritic spine; glutamatergic synapse; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 6 | 109162499 | 109284527 | Rat | 151 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308159 | Lnx1 | ligand of numb-protein X 1 | ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN synapse maturation (ortholog); ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCI ATED WITH head and neck squamous cell carcinoma (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 14 | 33868517 | 33971217 | Rat | 115 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308222 | Lnx2 | ligand of numb-protein X 2 | ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN neural precursor cell proliferation (ortholog); neuron differentiation (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8 -tetrachlorodibenzodioxine | 12 | 13119139 | 13184401 | Rat | 82 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307579 | Numbl | NUMB-like, endocytic adaptor protein | INVOLVED IN positive regulation of dendrite morphogenesis; regulation of postsynapse assembly; adherens junction organization (ortholog); PARTICIPATES IN Notch signaling pathway; FOUND IN glutamatergic synapse; cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenz odioxine; 4,4'-sulfonyldiphenol | 1 | 91677437 | 91701415 | Rat | 96 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1560628 | Duoxa2 | dual oxidase maturation factor 2 | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN hydrogen peroxide biosynthetic process (ortholog); hydrogen peroxide metabolic process (ortholog); intracellular protein localization (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); familial thyroid dyshormonoge nesis (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); cell leading edge (ortholog); cytosol (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 129698938 | 129702656 | Rat | 69 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 621466 | Il2rg | interleukin 2 receptor subunit gamma | ENCODES a protein that exhibits coreceptor activity (ortholog); interleukin-15 receptor activity (ortholog); interleukin-2 binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular homeostasis (ortholog); interleukin-15-mediated signaling pathway (orth olog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; decreased CD8-positive, alpha-beta T cell number; ASSOCIATED WITH combined T cell and B cell immunodeficiency; Immune Deficiency Disease; X-linked severe combined immunodeficiency; FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane | X | 70435340 | 70439052 | Rat | 156 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13628731 | Il2rgem1Ang | interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang | ASSOCIATED WITH decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; decreased CD8-positive, alpha-beta T cell number; ASSOCIATED WITH Immune Deficiency D isease | | | | Rat | 10 | description | gene, allele |
| 619790 | Rag1 | recombination activating 1 | ENCODES a protein that exhibits endonuclease activity (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN regulation of behavioral fear response; visual learning; adaptive immune response (ortholog); PARTICIPATES IN primary immunodeficiency pathway; ASSOCIATED W ITH decreased B cell number; decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; ASSOCIATED WITH Albuminuria; hypertension; Hypertensive Nephropathy; FOUND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; amphetamine | 3 | 108372087 | 108383184 | Rat | 222 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 7204135 | Rag1em1Ang | recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon | ASSOCIATED WITH decreased B cell number; decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; ASSOCIATED WITH Immune Deficiency Disease; severe combined i mmunodeficiency | | | | Rat | 15 | description | gene, allele |
| 620062 | Pon1 | paraoxonase 1 | ENCODES a protein that exhibits aryldialkylphosphatase activity; acyl-L-homoserine-lactone lactonohydrolase activity (ortholog); arylesterase activity (ortholog); INVOLVED IN response to fatty acid; response to fluoride; response to lipopolysaccharide; PARTICIPATES IN clopidogrel pharmacodynamics pa thway; clopidogrel pharmacokinetics pathway; organophosphate response pathway; ASSOCIATED WITH arrested T cell differentiation; decreased B cell number; decreased T cell number; ASSOCIATED WITH Hyperlipoproteinemias; Hypertriglyceridemia; Spinal Cord Injuries; FOUND IN extracellular space; high-density lipoprotein particle (ortholog); spherical high-density lipoprotein particle (ortholog); INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; 17beta-estradiol | 4 | 34261312 | 34292327 | Rat | 683 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 124715481 | Pon1em1Lizh | paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh | ASSOCIATED WITH arrested T cell differentiation; decreased B cell number; decreased T cell number | | | | Rat | 9 | description | gene, allele |
| 4139865 | Rag1em1Mcwi | recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | ASSOCIATED WITH decreased B cell number; decreased T cell number; decreased thymus weight; ASSOCIATED WITH Albuminuria; Hypertensive Nephropathy | | | | Rat | 7 | description | gene, allele |
| 7204132 | Rag1em1Ztm | recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover | ASSOCIATED WITH decreased B cell number; decreased T cell number; small thymus; ASSOCIATED WITH severe combined immunodeficiency | | | | Rat | 4 | description | gene, allele |
| 5509982 | Sh2b3em2Mcwi | SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin | ASSOCIATED WITH decreased heart ventricle muscle contractility; increased lymphocyte cell number; increased monocyte cell number; ASSOCIATED WITH Myocardial Reperfusion Injury | | | | Rat | 5 | description | gene, allele |
| 1311139 | Aire | autoimmune regulator | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN central tolerance induction to self antigen (ortholog); humoral immune response (ortholog); negative thymic T cell selection (ortholog); PARTICIPATES IN primary immunodeficiency pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal NK cell number; abnormal thymus morphology; alopecia; ASSOCIATED WITH autoimmune polyendocrine syndrome; autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleus (ortholog); INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride | 20 | 10635775 | 10650709 | Rat | 129 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 38599148 | Aireem1Ang | autoimmune regulator; ZFN induced mutant1, Ang | ASSOCIATED WITH abnormal NK cell number; abnormal thymus morphology; alopecia; ASSOCIATED WITH autoimmune polyendocrine syndrome | | | | Rat | 10 | description | gene, allele |
| 1306571 | Arsg | arylsulfatase G | ENCODES a protein that exhibits arylsulfatase activity (ortholog); N-sulfoglucosamine-3-sulfatase activity (ortholog); INVOLVED IN gene expression (ortholog); glial cell differentiation (ortholog); homeostasis of number of cells (ortholog); ASSOCIATED WITH autis m spectrum disorder (ortholog); fundus dystrophy (ortholog); mucopolysaccharidosis (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); lysosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 10 | 94912094 | 95063021 | Rat | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306637 | Atxn2 | ataxin 2 | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN cerebellar Purkinje cell differentiation (ortholog); homeostasis of number of cells (ortholog); negative regulation of multicellular organism growth (ortholog); ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A | 12 | 40413657 | 40509895 | Rat | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2305 | Cd247 | Cd247 molecule | ENCODES a protein that exhibits identical protein binding (ortholog); MHC class II receptor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell surface receptor signaling pathway; Fc-gamma receptor signaling pathway (ortholog); positive regulation of protein localiz ation to cell surface (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; Chagas disease pathway; T cell receptor signaling pathway; ASSOCIATED WITH absent alpha-beta T cells; decreased B cell number; decreased mean systemic arterial blood pressure; ASSOCIATED WITH COVID-19 (ortholog); immunodeficiency 25 (ortholog); severe combined immunodeficiency (ortholog); FOUND IN T cell receptor complex; alpha-beta T cell receptor complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 13 | 80576264 | 80651422 | Rat | 149 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 5687703 | Cd247em1Mcwi | Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | ASSOCIATED WITH absent alpha-beta T cells; decreased B cell number; decreased mean systemic arterial blood pressure | | | | Rat | 9 | description | gene, allele |
| 13792720 | Cd59em1Ask | CD59 molecule; CRISPR/Cas9 induced mutant1, Ask | ASSOCIATED WITH decreased erythrocyte cell number; increased red blood cell distribution width; increased susceptibility to type III hypersensitivity reaction; ASSOCIATED WITH neuromyelitis optica | | | | Rat | 5 | description | gene, allele |
| 2311 | Cd59b | CD59b molecule | ENCODES a protein that exhibits complement binding; protein sequestering activity (ortholog); INVOLVED IN negative regulation of activation of membrane attack complex; negative regulation of apoptotic process; negative regulation of complement-dependent cytotoxicity; PARTICIPATES IN coagulation casc ade pathway; complement system pathway; ASSOCIATED WITH decreased erythrocyte cell number; increased red blood cell distribution width; increased susceptibility to type III hypersensitivity reaction; ASSOCIATED WITH acute necrotizing pancreatitis; alcohol-associated liver disease; anterior uveitis; FOUND IN compact myelin; extracellular space; sarcolemma; INTERACTS WITH (+)-schisandrin B; 1,3-Propane sultone; 17alpha-ethynylestradiol | 3 | 110914008 | 110932489 | Rat | 218 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310015 | Cd7 | Cd7 molecule | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); positive regulation of T cell cytokine production (ortholog); ASSOCIATED WITH amyotrophic lateral scleros is type 1 (ortholog); Experimental Liver Cirrhosis (ortholog); Spontaneous Abortions (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 10 | 106802373 | 106805269 | Rat | 61 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1592336 | Clpsl2 | colipase-like 2 | ENCODES a protein that exhibits enzyme activator activity (inferred); INVOLVED IN acrosome reaction (ortholog); homeostasis of number of cells (ortholog); single fertilization (ortholog); FOUND IN acrosomal vesicle (ortholog); sperm flagellum (ortholog); INTERAC TS WITH acrylamide; bisphenol A; 3-methylcholanthrene (ortholog) | 20 | 6609832 | 6612655 | Rat | 21 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305806 | Col14a1 | collagen type XIV alpha 1 chain | INVOLVED IN collagen fibril organization (ortholog); homeostasis of number of cells within a tissue (ortholog); regulation of cell growth involved in cardiac muscle cell development (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN interstitial matrix (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 7 | 88611827 | 88826939 | Rat | 154 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310332 | Cyfip1 | cytoplasmic FMR1 interacting protein 1 | ENCODES a protein that exhibits RNA 7-methylguanosine cap binding; small GTPase binding (ortholog); translation repressor activity (ortholog); INVOLVED IN cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; positive regulation of axon extension; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH abnormal brain white matter morphology; decreased myelin sheath thickness; decreased oligodendrocyte number; ASSOCIATED WITH temporal lobe epilepsy; autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN axonal growth cone; central region of growth cone; dendritic growth cone; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,4-methylenedioxymethamphetamine | 1 | 115842754 | 115935163 | Rat | 149 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14985211 | Cyfip1em1Sage | cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage | ASSOCIATED WITH abnormal brain white matter morphology; decreased myelin sheath thickness; decreased oligodendrocyte number | | | | Rat | 3 | description | gene, allele |
| 2323810 | Cylc1 | cylicin 1 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN acrosome assembly (ortholog); cell morphogenesis (ortholog); maintenance of cell number (ortholog); ASSOCIATED WITH male infertility (ortholog); X-linked spermatogenic fail ure 8 (ortholog); FOUND IN acrosomal matrix (ortholog); acrosomal membrane (ortholog); acrosomal vesicle (ortholog); INTERACTS WITH aflatoxin B1 (ortholog); cadmium dichloride (ortholog); CGP 52608 (ortholog) | X | 80224288 | 80313698 | Rat | 36 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562799 | Cylc2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog ); sperm glycocalyx (ortholog); INTERACTS WITH 2-palmitoylglycerol (ortholog); aflatoxin B1 (ortholog); raloxifene (ortholog) | 5 | 70349791 | 70384673 | Rat | 22 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2314903 | F8m1Ycb | coagulation factor VIII, procoagulant component; mutation 1, Ycb | ASSOCIATED WITH decreased erythrocyte cell number; decreased hematocrit; decreased hemoglobin content; ASSOCIATED WITH factor VIII deficiency | | | | Rat | 4 | description | gene, allele |
| 1561045 | Fance | FA complementation group E | INVOLVED IN gene expression (ortholog); homeostasis of number of cells (ortholog); ovarian follicle development (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colon carcinoma (ortholog); F OUND IN chromatin (ortholog); Fanconi anaemia nuclear complex (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 20 | 6371153 | 6388366 | Rat | 81 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563891 | Gcnt4 | glucosaminyl (N-acetyl) transferase 4 | ENCODES a protein that exhibits glycosyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN homeostasis of number of cells (ortholog); inter-male aggressive behavior (ortholog); kidney morphogenesis (ortholog); FOUND IN Golgi apparatus (ortholog); INTERACTS WITH 4,4'-diaminodiphenylmethane; bisphenol A; DDT | 2 | 29987944 | 30017708 | Rat | 59 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2318130 | Gigyf2 | GRB10 interacting GYF protein 2 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); feeding behavior (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WI TH Neurodevelopmental Disorders (ortholog); Parkinson's Disease 11 (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; bisphenol A; Cuprizon | 9 | 95449143 | 95574927 | Rat | 138 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 15004087 | Ighm | immunoglobulin heavy constant epsilon | INVOLVED IN immune system process (inferred); PARTICIPATES IN allograft rejection pathway; ASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiency; FOUND IN immunoglobulin complex (inferred) | | | | Rat | 12 | description | gene, protein-coding |
| 150523756 | Ighmem1Ang | immunoglobulin heavy constant mu; ZFN induced mutant1, Ang | ASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiency | | | | Rat | 7 | description | gene, allele |
| 150523758 | Ighmem2Ang | immunoglobulin heavy constant mu; ZFN induced mutant2, Ang | ASSOCIATED WITH decreased B cell number; decreased IgA level; decreased IgE level; ASSOCIATED WITH B cell deficiency | | | | Rat | 7 | description | gene, allele |
| 2887 | Il15 | interleukin 15 | ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cellular response to vitamin D; hyaluronan metabolic process; negative regulation of smooth muscle cell proliferation; PARTICIPATES IN Jak-Stat signaling pathway; cytokine mediated signaling pathway; rheumatoid arthritis pathw ay; ASSOCIATED WITH abnormal placenta junctional zone morphology; abnormal uterine spiral artery morphology; decreased NK cell number; ASSOCIATED WITH Experimental Autoimmune Myasthenia Gravis; Inflammation; listeriosis; FOUND IN cell surface; extracellular space; cytoplasm (ortholog); INTERACTS WITH (+)-taxifolin; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 19 | 42536160 | 42611349 | Rat | 298 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12910491 | Il15em1Soar | interleukin 15; ZFN induced mutant 1, Soar | ASSOCIATED WITH abnormal placenta junctional zone morphology; abnormal uterine spiral artery morphology; decreased NK cell number | | | | Rat | 4 | description | gene, allele |
| 1566151 | Il20rb | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); PARTICIPA TES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH toxic shock syndrome (ortholog); INTERACTS WITH alpha-Zearalanol; bisphenol A; gentamycin | 8 | 109858108 | 109896066 | Rat | 106 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1596420 | Ildr2 | immunoglobulin-like domain containing receptor 2 | INVOLVED IN cell differentiation (ortholog); homeostasis of number of cells within a tissue (ortholog); insulin secretion (ortholog); FOUND IN tight junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A | 13 | 81051723 | 81113590 | Rat | 97 | description | gene, protein-coding, MODEL [RefSeq] |
| 708458 | Jmjd1c | jumonji domain containing 1C | ENCODES a protein that exhibits histone H3K9 demethylase activity (ortholog); protein demethylase activity (ortholog); INVOLVED IN epithelial cell morphogenesis (ortholog); lipid biosynthetic process (ortholog); maintenance of cell number (ortholog); PARTICIPATE S IN histone modification pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 17beta-estradiol; ammonium chloride; amphetamine | 20 | 21330990 | 21508580 | Rat | 146 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621446 | Klf5 | KLF transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding; transcription factor binding; DNA binding (ortholog); INVOLVED IN cellular response to endothelin; positive regulation of cell population proliferation; angiogenesis (ortholog); ASSOCIATED WITH abnormal postsynaptic density morphology; a bnormal protein level; decreased neuron number; ASSOCIATED WITH Intimal Hyperplasia; metabolic dysfunction and alcohol associated liver disease; Neointima; FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription regulator complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol | 15 | 82472081 | 82487267 | Rat | 303 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303290 | Klhl10 | kelch-like family member 10 | INVOLVED IN cell morphogenesis (ortholog); fertilization (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH spermatogenic failure 11 (ortholog); spermatogenic failure 3 (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; azoxystrobin; bisphenol A | 10 | 85876804 | 85893081 | Rat | 44 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620802 | Lat | linker for activation of T cells | ENCODES a protein that exhibits molecular condensate scaffold activity (ortholog); protein kinase binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); gene expression (ortholog); homeostasis of number of c ells (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; Fc gamma receptor mediated signaling pathway; T cell receptor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); IgG4-related disease (ortholog); immunodeficiency 52 (ortholog); FOUND IN cell-cell junction (ortholog); COP9 signalosome (ortholog); immunological synapse (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol | 1 | 190367111 | 190372515 | Rat | 141 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3000 | Lep | leptin | ENCODES a protein that exhibits hormone activity; peptide hormone receptor binding; signaling receptor binding; INVOLVED IN bone mineralization involved in bone maturation; cardiac muscle hypertrophy; cellular response to L-ascorbic acid; PARTICIPATES IN energy homeostasis pathway; leptin system pat hway; hypoxia inducible factor pathway; ASSOCIATED WITH abnormal interferon level; decreased T cell number; increased body weight; ASSOCIATED WITH acute pancreatitis; alcohol dependence; alcoholic liver cirrhosis; FOUND IN cytosol; extracellular space; cytoplasm (ortholog); INTERACTS WITH (+)-catechin; (+)-taxifolin; (R)-lipoic acid | 4 | 58626529 | 58640663 | Rat | 1063 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12904927 | Lepem1Sage | leptin; zinc finger nuclease induced mutant1, Sage | ASSOCIATED WITH abnormal interferon level; decreased T cell number; increased body weight; ASSOCIATED WITH glucose intolerance; Hypercholesterolemia; hyperinsulinism | | | | Rat | 11 | description | gene, allele |
| 1303311 | Lrrc46 | leucine rich repeat containing 46 | INVOLVED IN axoneme assembly (ortholog); maintenance of cell number (ortholog); single fertilization (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN sperm flagellum (ortholog); sperm midpiece (ortholog); INTERACTS WITH 17alpha-ethynylestradiol ; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 10 | 82517767 | 82530011 | Rat | 48 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2325346 | Mir195 | microRNA 195 | ENCODES an ncrna that exhibits lncRNA binding (ortholog); mRNA 3'-UTR binding (ortholog); mRNA base-pairing post-transcriptional repressor activity (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); long-term synaptic potentiation (ortholog); miRNA-mediated gene silencing by mRNA destabilization (ortholog); ASSOCIATED WITH abnormal neuron number; abnormal postsynaptic density morphology; abnormal protein level; ASSOCIATED WITH alcohol use disorder; hepatocellular carcinoma; transient cerebral ischemia; FOUND IN extracellular exosome (ortholog); RISC complex (ortholog); INTERACTS WITH 3,7-dihydropurine-6-thione; aflatoxin B1; aldehydo-D-glucose | 10 | 55450495 | 55450581 | Rat | 81 | description | gene, ncrna, PROVISIONAL [RefSeq] |
| 69406 | Pclo | piccolo (presynaptic cytomatrix protein) | ENCODES a protein that exhibits calcium ion binding; calcium-dependent phospholipid binding; transcription corepressor binding; INVOLVED IN modulation of excitatory postsynaptic potential; positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; ASSOCIATED WITH abnormal c erebellar glomerulus morphology; abnormal synaptic vesicle number; abnormal synaptic vesicle recycling; ASSOCIATED WITH genetic disease (ortholog); microcephaly (ortholog); pontocerebellar hypoplasia type 3 (ortholog); FOUND IN axon; cone cell pedicle; cytoskeleton of presynaptic active zone; INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 20646604 | 21005171 | Rat | 177 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 41408340 | PcloTn(sb-B-Geo)Fkh | presynaptic cytomatrix protein; sleeping beauty transposon induced mutant, Fkh | ASSOCIATED WITH abnormal cerebellar glomerulus morphology; abnormal synaptic vesicle number; abnormal synaptic vesicle recycling | | | | Rat | 11 | description | gene, allele |
| 628752 | Rab38 | RAB38, member RAS oncogene family | ENCODES a protein that exhibits GTP binding; AP-1 adaptor complex binding (ortholog); AP-2 adaptor complex binding (ortholog); INVOLVED IN platelet dense granule organization; positive regulation of melanin biosynthetic process; positive regulation of phosphatidylcholine biosynthetic process; ASSOCI ATED WITH abnormal coat/hair pigmentation; abnormal platelet dense granule number; abnormal surfactant secretion; ASSOCIATED WITH Albuminuria; Hermansky-Pudlak syndrome; proteinuria; FOUND IN cell body; melanosome; perinuclear region of cytoplasm; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 151595153 | 151675492 | Rat | 172 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1600311 | Rab38ru | Rab38, member of RAS oncogene family, ruby allele | ASSOCIATED WITH abnormal coat/hair pigmentation; abnormal platelet dense granule number; abnormal surfactant secretion; ASSOCIATED WITH Hermansky-Pudlak syndrome | | | | Rat | 7 | description | gene, allele |
| 1305588 | Rag2 | recombination activating 2 | ENCODES a protein that exhibits chromatin binding (ortholog); histone H3K4me3 reader activity (ortholog); phosphatidylinositol binding (ortholog); INVOLVED IN mature B cell differentiation involved in immune response; negative regulation of T cell differentiation in thymus; B cell differentiation (o rtholog); PARTICIPATES IN histone modification pathway; primary immunodeficiency pathway; ASSOCIATED WITH absent mature B cells; decreased double-positive T cell number; decreased thymus weight; ASSOCIATED WITH severe combined immunodeficiency; combined cellular and humoral immune defects with granulomas (ortholog); common variable immunodeficiency (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH ammonium chloride; copper atom; copper(0) | 3 | 108357399 | 108367186 | Rat | 106 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1305551 | Rassf2 | Ras association domain family member 2 | ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN bone remodeling (ortholog); canonical NF-kappaB signal transduction (ortholog); homeostasis of number of cells (ortholog); ASSOCIATED WITH Lymphatic Metastasis (ortholog); Nasopharyn geal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); kinetochore (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 3 | 139697187 | 139733402 | Rat | 146 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311646 | Sart3 | spliceosome associated factor 3, U4/U6 recycling protein | ENCODES a protein that exhibits histone binding (ortholog); protein-macromolecule adaptor activity (ortholog); U4 snRNA binding (ortholog); INVOLVED IN cell morphogenesis (ortholog); hematopoietic stem cell proliferation (ortholog); homeostasis of number of cell s (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Porokeratosis 3, Multiple Types (ortholog); FOUND IN Cajal body (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; C60 fullerene | 12 | 48519579 | 48547584 | Rat | 141 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1560293 | Sash3 | SAM and SH3 domain containing 3 | INVOLVED IN homeostasis of number of cells within a tissue (ortholog); positive regulation of adaptive immune response (ortholog); positive regulation of B cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 1 02 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol | X | 132204717 | 132219421 | Rat | 88 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 4139858 | Sh2b3em1Mcwi | SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | ASSOCIATED WITH decreased susceptibility to hypertension; decreased urine albumin level; increased regulatory T cell number; ASSOCIATED WITH Albuminuria; hypertension | | | | Rat | 5 | description | gene, allele |
| 1311266 | Tex15 | testis expressed 15, meiosis and synapsis associated | INVOLVED IN DNA methylation-dependent constitutive heterochromatin formation (ortholog); fertilization (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH myoepithelioma (ortholog); spermatogenic failure 1 (ortholog); spermatog enic failure 25 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A | 16 | 65302049 | 65362065 | Rat | 93 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564531 | Trpv3 | transient receptor potential cation channel, subfamily V, member 3 | ENCODES a protein that exhibits calcium channel activity (ortholog); identical protein binding (ortholog); monoatomic cation channel activity (ortholog); INVOLVED IN positive regulation of calcium ion import; negative regulation of hair cycle (ortholog); response to temperature stimulus (ortholog); ASSOCIATED WITH increased mast cell number; ASSOCIATED WITH alopecia; dermatitis; atopic dermatitis (ortholog); FOUND IN cytoplasm (ortholog); lysosome (ortholog); membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; amphetamine | 10 | 58382054 | 58413657 | Rat | 165 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564601 | Vpreb1b | V-set pre-B cell surrogate light chain 1B | INVOLVED IN B cell proliferation (ortholog); cell morphogenesis (ortholog); homeostasis of number of cells (ortholog); INTERACTS WITH bisphenol A; furan; indole-3-methanol | 11 | 96513694 | 96514404 | Rat | 20 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1562664 | Zfx | zinc finger protein X-linked | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN fertilization (ortholog); germ cell development (ortholog); homeostasis of numb ont-weight:700;'>number of cells (ortholog); ASSOCIATED WITH syndromic X-linked intellectual developmental disorder 37 (ortholog); FOUND IN chromatin (ortholog); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole | X | 62798483 | 62847068 | Rat | 103 | description | gene, protein-coding, VALIDATED [RefSeq] |