Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Lnx2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of LNX2 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of LNX2 mRNA | CTD | PMID:30723492 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of LNX2 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LNX2 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | LNX2 (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of LNX2 mRNA | CTD | PMID:29704546 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Lnx2 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of LNX2 mRNA | CTD | PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lnx2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LNX2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LNX2 mRNA | CTD | PMID:22298810 | 2-hydroxypropanoic acid | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of LNX2 mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Lnx2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of LNX2 mRNA | CTD | PMID:26251327 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Lnx2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of LNX2 mRNA | CTD | PMID:18648102 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LNX2 mRNA | CTD | PMID:24780913 | aflatoxin B1 | decreases methylation | ISO | LNX2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of LNX2 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of LNX2 mRNA | CTD | PMID:33167477 | aristolochic acid A | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of LNX2 mRNA | CTD | PMID:33212167 | azoxystrobin | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LNX2 mRNA | CTD | PMID:33854195 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of LNX2 mRNA | CTD | PMID:25181051 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of LNX2 mRNA | CTD | PMID:19167457 | CGP 52608 | multiple interactions | ISO | LNX2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LNX2 gene] | CTD | PMID:28238834 | chlorpyrifos | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LNX2 mRNA | CTD | PMID:33854195 | choline | multiple interactions | ISO | Lnx2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LNX2 gene | CTD | PMID:20938992 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of LNX2 mRNA | CTD | PMID:24386269 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of LNX2 mRNA | CTD | PMID:26577399 and PMID:27523638 | cyclosporin A | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of LNX2 mRNA | CTD | PMID:25562108 | dibenz[a,h]anthracene | decreases expression | ISO | Lnx2 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | doxorubicin | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of LNX2 mRNA | CTD | PMID:29803840 | epoxiconazole | increases expression | ISO | Lnx2 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of LNX2 mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of LNX2 mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | Lnx2 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | formaldehyde | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of LNX2 mRNA | CTD | PMID:23649840 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of LNX2 gene | CTD | PMID:22079235 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of LNX2 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of LNX2 mRNA | CTD | PMID:24136188 | glyphosate | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LNX2 mRNA | CTD | PMID:33854195 | Heptachlor epoxide | increases expression | ISO | Lnx2 (Mus musculus) | 6480464 | Heptachlor Epoxide results in increased expression of LNX2 mRNA | CTD | PMID:25270620 | imidacloprid | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LNX2 mRNA | CTD | PMID:33854195 | L-methionine | multiple interactions | ISO | Lnx2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LNX2 gene | CTD | PMID:20938992 | leflunomide | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of LNX2 mRNA | CTD | PMID:28988120 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of LNX2 gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of LNX2 mRNA | CTD | PMID:23649840 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Lnx2 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of LNX2 mRNA | CTD | PMID:27776689 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LNX2 mRNA | CTD | PMID:33387578 | phenobarbital | decreases expression | ISO | Lnx2 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of LNX2 mRNA | CTD | PMID:19270015 | pirinixic acid | increases expression | ISO | Lnx2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of LNX2 mRNA | CTD | PMID:23811191 | quercetin | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of LNX2 mRNA | CTD | PMID:21632981 | rac-lactic acid | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of LNX2 mRNA | CTD | PMID:30851411 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of LNX2 mRNA | CTD | PMID:28374803 | sodium arsenite | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of LNX2 mRNA | CTD | PMID:34032870 | sunitinib | decreases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of LNX2 mRNA | CTD | PMID:31533062 | tert-butyl hydroperoxide | decreases methylation | ISO | LNX2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased methylation of LNX2 intron | CTD | PMID:29432895 | thiabendazole | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LNX2 mRNA | CTD | PMID:33854195 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of LNX2 mRNA | CTD | PMID:34492290 | trichostatin A | affects expression | ISO | LNX2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of LNX2 mRNA | CTD | PMID:28542535 | triphenyl phosphate | decreases expression | EXP | | 6480464 | triphenyl phosphate results in decreased expression of LNX2 mRNA | CTD | PMID:30589522 | tungsten | decreases expression | ISO | Lnx2 (Mus musculus) | 6480464 | Tungsten results in decreased expression of LNX2 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | LNX2 (Homo sapiens) | 6480464 | Urethane results in increased expression of LNX2 mRNA | CTD | PMID:28818685 | valproic acid | decreases methylation | ISO | LNX2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of LNX2 gene | CTD | PMID:29154799 | |