Rag2 (recombination activating 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Rag2 (recombination activating 2) Rattus norvegicus
Analyze
Symbol: Rag2
Name: recombination activating 2
RGD ID: 1305588
Description: Predicted to enable several functions, including chromatin binding activity; ion binding activity; and methylated histone binding activity. Involved in mature B cell differentiation involved in immune response and negative regulation of T cell differentiation in thymus. Predicted to be located in nucleus. Predicted to be part of DNA recombinase complex. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2); PARTICIPATES IN histone modification pathway; primary immunodeficiency pathway; INTERACTS WITH ammonium chloride; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295953; recombination activating gene 2; recombination activating protein 2; V(D)J recombination-activating protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Rag2em2Mcwi   Rag2em3Mcwi   Rag2em1Mcwi   Rag2em1Sage   Rag2em1Iexas  
Genetic Models: SD-Rag2em2Mcwi SS-Rag2em1Mcwi SD-Rag2em3Mcwi SD-Rag2em3McwiIl2rgem2Mcwi SD-Rag2em1Sage F344-Rag2em1Sage F344-Il2rgem1IexasRag2em1Iexas F344-Rag2em1Iexas
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,357,399 - 108,367,186 (+)NCBIGRCr8
mRatBN7.2387,902,373 - 87,910,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl387,902,238 - 87,911,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,393,248 - 91,401,103 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0399,992,269 - 100,000,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0397,824,520 - 97,832,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,191,837 - 91,200,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,191,837 - 91,200,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0397,851,318 - 97,859,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4386,764,810 - 86,773,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1386,661,236 - 86,668,153 (+)NCBI
Celera387,008,586 - 87,016,420 (+)NCBICelera
Cytogenetic Map3q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts. Noto FK, etal., Mol Cancer Ther. 2018 Nov;17(11):2481-2489. doi: 10.1158/1535-7163.MCT-18-0156. Epub 2018 Sep 11.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. RAG mutations in human B cell-negative SCID. Schwarz K, etal., Science. 1996 Oct 4;274(5284):97-9.
13. Partial V(D)J recombination activity leads to Omenn syndrome. Villa A, etal., Cell. 1998 May 29;93(5):885-96.
Additional References at PubMed
PMID:1547487   PMID:1547488   PMID:2360047   PMID:8788039   PMID:9052834   PMID:9252127   PMID:9875844   PMID:11214319   PMID:11980719   PMID:14530129   PMID:14595002   PMID:14766966  
PMID:15964836   PMID:18025461   PMID:18033247   PMID:19448632  


Genomics

Comparative Map Data
Rag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,357,399 - 108,367,186 (+)NCBIGRCr8
mRatBN7.2387,902,373 - 87,910,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl387,902,238 - 87,911,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,393,248 - 91,401,103 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0399,992,269 - 100,000,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0397,824,520 - 97,832,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,191,837 - 91,200,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,191,837 - 91,200,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0397,851,318 - 97,859,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4386,764,810 - 86,773,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1386,661,236 - 86,668,153 (+)NCBI
Celera387,008,586 - 87,016,420 (+)NCBICelera
Cytogenetic Map3q31NCBI
RAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381136,590,996 - 36,598,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1136,575,574 - 36,598,279 (-)EnsemblGRCh38hg38GRCh38
GRCh371136,613,493 - 36,619,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361136,570,069 - 36,576,388 (-)NCBINCBI36Build 36hg18NCBI36
Celera1136,765,924 - 36,772,260 (-)NCBICelera
Cytogenetic Map11p12NCBI
HuRef1136,316,277 - 36,322,614 (-)NCBIHuRef
CHM1_11136,612,179 - 36,618,515 (-)NCBICHM1_1
T2T-CHM13v2.01136,734,171 - 36,741,410 (-)NCBIT2T-CHM13v2.0
Rag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,455,057 - 101,462,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,455,063 - 101,462,874 (+)EnsemblGRCm39 Ensembl
GRCm382101,624,712 - 101,632,528 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,624,718 - 101,632,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,464,905 - 101,472,685 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,425,587 - 101,433,367 (+)NCBIMGSCv36mm8
Celera2102,849,742 - 102,857,519 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.87NCBI
Rag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554229,867,307 - 9,869,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554229,867,307 - 9,869,732 (+)NCBIChiLan1.0ChiLan1.0
RAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2938,806,254 - 38,808,778 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11138,810,920 - 38,813,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,558,419 - 36,564,997 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,431,067 - 36,437,390 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,431,703 - 36,433,286 (-)Ensemblpanpan1.1panPan2
RAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,614,143 - 31,621,489 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,618,481 - 31,620,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,225,259 - 31,228,771 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,228,286 - 32,231,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,228,787 - 32,230,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11831,798,300 - 31,801,806 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,382,649 - 31,386,158 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,019,854 - 32,023,367 (+)NCBIUU_Cfam_GSD_1.0
Rag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494728,680,736 - 28,683,548 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365331,801,391 - 1,807,431 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365331,801,207 - 1,807,431 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,547,644 - 24,558,403 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,547,605 - 24,553,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2226,716,416 - 26,717,999 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1128,645,175 - 28,653,823 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl128,649,930 - 28,651,513 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038125,790,092 - 125,792,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476710,678,359 - 10,680,132 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476710,678,547 - 10,680,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rag2
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:99
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000006097
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat

Markers in Region
Rag2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2387,906,536 - 87,907,242 (+)MAPPERmRatBN7.2
mRatBN7.2387,906,902 - 87,907,242 (+)MAPPERmRatBN7.2
Rnor_6.0391,196,367 - 91,197,149NCBIRnor6.0
Rnor_6.0391,196,810 - 91,197,149NCBIRnor6.0
Rnor_5.0397,856,291 - 97,856,630UniSTSRnor5.0
Rnor_5.0397,855,848 - 97,856,630UniSTSRnor5.0
RGSC_v3.4386,770,114 - 86,770,453UniSTSRGSC3.4
Celera387,013,090 - 87,013,429UniSTS
Cytogenetic Map3q31UniSTS
UniSTS:259651  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera387,011,896 - 87,013,491UniSTS
Cytogenetic Map3q31UniSTS
PMC196132P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2387,906,536 - 87,907,220 (+)MAPPERmRatBN7.2
mRatBN7.2387,906,897 - 87,907,220 (+)MAPPERmRatBN7.2
Rnor_6.0391,196,362 - 91,197,127NCBIRnor6.0
Rnor_6.0391,196,805 - 91,197,127NCBIRnor6.0
Rnor_5.0397,856,286 - 97,856,608UniSTSRnor5.0
Rnor_5.0397,855,843 - 97,856,608UniSTSRnor5.0
RGSC_v3.4386,770,109 - 86,770,431UniSTSRGSC3.4
Celera387,013,085 - 87,013,407UniSTS
Cytogenetic Map3q31UniSTS


Genetic Models
This gene Rag2 is modified in the following models/strains:
SD-Rag2em2Mcwi     SS-Rag2em1Mcwi     SD-Rag2em3Mcwi     SD-Rag2em3McwiIl2rgem2Mcwi     SD-Rag2em1Sage     F344-Rag2em1Sage     F344-Il2rgem1IexasRag2em1Iexas     F344-Rag2em1Iexas    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 7
Low 14 12 11 12 1 3 4
Below cutoff 2 14 27 20 1 20 8 8 8 10 17 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006097   ⟹   ENSRNOP00000006097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl387,902,238 - 87,911,066 (+)Ensembl
Rnor_6.0 Ensembl391,191,837 - 91,200,134 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103802   ⟹   ENSRNOP00000086217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl387,902,238 - 87,911,066 (+)Ensembl
RefSeq Acc Id: NM_001100528   ⟹   NP_001093998
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83108,357,399 - 108,365,253 (+)NCBI
mRatBN7.2387,902,373 - 87,910,227 (+)NCBI
Rnor_6.0391,191,837 - 91,200,134 (+)NCBI
Rnor_5.0397,851,318 - 97,859,615 (+)NCBI
RGSC_v3.4386,764,810 - 86,773,438 (+)RGD
Celera387,008,586 - 87,016,420 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283306   ⟹   XP_063139376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83108,358,850 - 108,367,186 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001093998 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139376 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG38684 (Get FASTA)   NCBI Sequence Viewer  
  AAQ77003 (Get FASTA)   NCBI Sequence Viewer  
  EDL79623 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006097
  ENSRNOP00000006097.4
  ENSRNOP00000086217.1
Reference Protein Sequences
RefSeq Acc Id: NP_001093998   ⟸   NM_001100528
- UniProtKB: G3V6K7 (UniProtKB/TrEMBL),   A6HNM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006097   ⟸   ENSRNOT00000006097
RefSeq Acc Id: ENSRNOP00000086217   ⟸   ENSRNOT00000103802
RefSeq Acc Id: XP_063139376   ⟸   XM_063283306
- Peptide Label: isoform X1
Protein Domains
Recombination activating protein 2 PHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6K7-F1-model_v2 AlphaFold G3V6K7 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692240
Promoter ID:EPDNEW_R2764
Type:initiation region
Name:Rag2_1
Description:recombination activating 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0391,191,830 - 91,191,890EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305588 AgrOrtholog
BioCyc Gene G2FUF-48612 BioCyc
Ensembl Genes ENSRNOG00000004623 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006097 ENTREZGENE
  ENSRNOT00000006097.6 UniProtKB/TrEMBL
  ENSRNOT00000103802.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
  Rag2 PHD finger UniProtKB/TrEMBL
InterPro Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  RAG2 UniProtKB/TrEMBL
  RAG2_PHD UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
KEGG Report rno:295953 UniProtKB/TrEMBL
NCBI Gene 295953 ENTREZGENE
PANTHER RAG2 UniProtKB/TrEMBL
  V(D)J RECOMBINATION-ACTIVATING PROTEIN 2 UniProtKB/TrEMBL
Pfam RAG2 UniProtKB/TrEMBL
  RAG2_PHD UniProtKB/TrEMBL
PhenoGen Rag2 PhenoGen
RatGTEx ENSRNOG00000004623 RatGTEx
Superfamily-SCOP Gal_oxid_central UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A6HNM2 ENTREZGENE, UniProtKB/TrEMBL
  G3V6K7 ENTREZGENE, UniProtKB/TrEMBL
  Q6W9A2_RAT UniProtKB/TrEMBL
  Q99NM1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 Rag2  recombination activating 2  Rag2  recombination activating gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rag2  recombination activating gene 2   Rag2_predicted  recombination activating gene 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rag2_predicted  recombination activating gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED