RGD Reference Report - A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. - Rat Genome Database

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A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7.

Authors: Alarmo, EL  Kuukasjarvi, T  Karhu, R  Kallioniemi, A 
Citation: Alarmo EL, etal., Breast Cancer Res Treat. 2007 Jun;103(2):239-46. Epub 2006 Sep 21.
RGD ID: 1643590
Pubmed: PMID:17004110   (View Abstract at PubMed)
DOI: DOI:10.1007/s10549-006-9362-1   (Journal Full-text)

Bone morphogenetic proteins (BMPs) regulate diverse cellular processes, such as proliferation, differentiation, and apoptosis. The BMPs have been studied in several cancers, but thus far contradictory results have been obtained and, especially in breast cancer, information on BMPs is still limited. We performed a systematic expression survey of BMPs and their receptors in breast cancer. mRNA expression was studied of seven BMP ligands (BMP2-BMP8) and six receptors (ACVR1, BMPR1A, BMPR1B, BMPR2, ACVR2A, and ACVR2B) that specifically mediate BMP signals. Expression levels were determined in 22 breast cancer cell lines, 39 primary breast tumors, normal human mammary epithelial cell line, and normal mammary gland using semiquantitative RT-PCR. The expression frequencies and expression levels of different BMPs varied considerably in breast cancer with BMP4 and BMP7 being most frequently expressed and showing highest expression levels. The BMP specific receptors were more uniformly expressed and indicated that breast cancer is fully capable of transmitting BMP signals. Expression frequencies and levels for both the ligands and the receptors were in good concordance between the breast cancer cell lines and primary tumors. We can conclude that breast cancers possess functional BMP signaling machinery on the cell surface with distinct differences in the expression of various BMP ligands. Our survey focuses the attention particularly toward BMP4 and BMP7 and suggests their importance in breast cancer. Breast cancer cell lines and the data generated here serve as a good resource for further studies on BMP function in breast cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer  IEP 1643590; 1643590mRNA:increased expression:breastRGD 
breast cancer  IEP 1643590mRNA:decreased expression:breastRGD 
breast cancer  ISOBMP4 (Homo sapiens)1643590; 1643590mRNA:increased expression:breastRGD 
breast cancer  ISOBMP6 (Homo sapiens)1643590; 1643590mRNA:decreased expression:breastRGD 
breast cancer  ISOBMP7 (Homo sapiens)1643590; 1643590mRNA:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp4  (bone morphogenetic protein 4)
Bmp6  (bone morphogenetic protein 6)
Bmp7  (bone morphogenetic protein 7)

Genes (Mus musculus)
Bmp4  (bone morphogenetic protein 4)
Bmp6  (bone morphogenetic protein 6)
Bmp7  (bone morphogenetic protein 7)

Genes (Homo sapiens)
BMP4  (bone morphogenetic protein 4)
BMP6  (bone morphogenetic protein 6)
BMP7  (bone morphogenetic protein 7)


Additional Information