RGD Reference Report - SNPs and haplotypes in the S100B gene reveal association with schizophrenia. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

SNPs and haplotypes in the S100B gene reveal association with schizophrenia.

Authors: Liu, Jixia  Shi, Yongyong  Tang, Junxia  Guo, Tingwei  Li, Xiuxia  Yang, Yifeng  Chen, Qingying  Zhao, Xinzhi  He, Guang  Feng, Guoyin  Gu, Niufan  Zhu, Shaomin  Liu, Huijun  He, Lin 
Citation: Liu J, etal., Biochem Biophys Res Commun. 2005 Mar 4;328(1):335-41. doi: 10.1016/j.bbrc.2004.12.175.
RGD ID: 14696780
Pubmed: PMID:15670788   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.12.175   (Journal Full-text)

The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (-960C>G), V2 (-111C>T), V3 (2757C>G, rs1051169), and V4 (5748C>T, rs9722) were studied. And haplotype V3-V4 (G-C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3-V4 (G-C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia susceptibilityIAGP 14696780DNA:SNPs more ...RGD 
schizophrenia susceptibilityISOS100B (Homo sapiens)14696780; 14696780DNA:SNPs more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Schizophrenia susceptibilityIAGP 14696780DNA:SNPs more ...RGD 
Schizophrenia susceptibilityIAGP 14696780DNA:SNPs:intron more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
S100b  (S100 calcium binding protein B)

Genes (Mus musculus)
S100b  (S100 protein, beta polypeptide, neural)

Genes (Homo sapiens)
S100B  (S100 calcium binding protein B)
SLC25A27  (solute carrier family 25 member 27)


Additional Information