Gene: S100B (S100 calcium binding protein B)  Homo sapiens
Symbol: S100B
Name: S100 calcium binding protein B
Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NEF; OTTHUMP00000115888; OTTHUMP00000174958; protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 beta; S100 calcium binding protein, beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); s100 protein, beta polypeptide; S100-B; S100beta
Orthologs: Mus musculus : S100b (S100 protein, beta polypeptide, neural)  MGI
Rattus norvegicus : S100b (S100 calcium binding protein B)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_12138,510,167 - 38,516,670-NCBI
Human Genome Assembly HuRef2133,398,429 - 33,404,960-NCBI
Human Genome Assembly GRCh372148,018,531 - 48,025,035-NCBI
Human Genome Assembly Build 362146,842,959 - 46,849,463-NCBI
Human Cytogenetic Map21q22.3 NCBI
Human Genome Assembly2146,842,958 - 46,849,424 NCBI
Model

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Sequence

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Nomenclature History
  
More on S100B
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
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Vista
Vista + UCSC

RGD Object Information
RGD ID: 737117
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-05-28
Status: ACTIVE



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