RGD Reference Report - The mechanism of eukaryotic translation initiation: new insights and challenges. - Rat Genome Database

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The mechanism of eukaryotic translation initiation: new insights and challenges.

Authors: Hinnebusch, AG  Lorsch, JR 
Citation: Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
RGD ID: 10044017
Pubmed: PMID:22815232   (View Abstract at PubMed)
PMCID: PMC3475172   (View Article at PubMed Central)
DOI: DOI:10.1101/cshperspect.a011544   (Journal Full-text)

Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs from in vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.

Objects Annotated

Genes (Rattus norvegicus)
Eif2b1  (eukaryotic translation initiation factor 2B subunit alpha)
Eif2b2  (eukaryotic translation initiation factor 2B subunit beta)
Eif2b3  (eukaryotic translation initiation factor 2B subunit gamma)
Eif2b4  (eukaryotic translation initiation factor 2B subunit delta)
Eif2b5  (eukaryotic translation initiation factor 2B subunit epsilon)
Eif2s1  (eukaryotic translation initiation factor 2 subunit alpha)
Eif2s2  (eukaryotic translation initiation factor 2 subunit beta)
Eif4g2  (eukaryotic translation initiation factor 4, gamma 2)
Pabpc1  (poly(A) binding protein, cytoplasmic 1)

Genes (Mus musculus)
Eif2b1  (eukaryotic translation initiation factor 2B, subunit alpha)
Eif2b2  (eukaryotic translation initiation factor 2B, subunit 2 beta)
Eif2b3  (eukaryotic translation initiation factor 2B, subunit 3)
Eif2b4  (eukaryotic translation initiation factor 2B, subunit 4 delta)
Eif2b5  (eukaryotic translation initiation factor 2B, subunit 5 epsilon)
Eif2s1  (eukaryotic translation initiation factor 2, subunit 1 alpha)
Eif2s2  (eukaryotic translation initiation factor 2 subunit 2 beta)
Eif4g1  (eukaryotic translation initiation factor 4, gamma 1)
Eif4g2  (eukaryotic translation initiation factor 4, gamma 2)
Pabpc1  (poly(A) binding protein, cytoplasmic 1)

Genes (Homo sapiens)
EIF2B1  (eukaryotic translation initiation factor 2B subunit alpha)
EIF2B2  (eukaryotic translation initiation factor 2B subunit beta)
EIF2B3  (eukaryotic translation initiation factor 2B subunit gamma)
EIF2B4  (eukaryotic translation initiation factor 2B subunit delta)
EIF2B5  (eukaryotic translation initiation factor 2B subunit epsilon)
EIF2S1  (eukaryotic translation initiation factor 2 subunit alpha)
EIF2S2  (eukaryotic translation initiation factor 2 subunit beta)
EIF2S3  (eukaryotic translation initiation factor 2 subunit gamma)
EIF4G1  (eukaryotic translation initiation factor 4 gamma 1)
EIF4G2  (eukaryotic translation initiation factor 4 gamma 2)
PABPC1  (poly(A) binding protein cytoplasmic 1)


Additional Information