Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EIF4G2 mRNA | CTD | PMID:36331819 | (S)-amphetamine | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Dextroamphetamine results in increased expression of EIF4G2 mRNA | CTD | PMID:10336889 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of EIF4G2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of EIF4G2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of EIF4G2 mRNA | CTD | PMID:15598610 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:20056577 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EIF4G2 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EIF4G2 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EIF4G2 mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,4,6-tribromophenol | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,6-dinitrotoluene | affects expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of EIF4G2 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of EIF4G2 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of EIF4G2 protein | CTD | PMID:31675489 | 3,4-Methylenedioxyamphetamine | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | 3 and 4-Methylenedioxyamphetamine results in increased expression of EIF4G2 mRNA | CTD | PMID:10336889 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of EIF4G2 mRNA | CTD | PMID:10336889 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of EIF4G2 mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF4G2 mRNA | CTD | PMID:28628672 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of EIF4G2 mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of EIF4G2 mRNA | CTD | PMID:18648102 | 6-propyl-2-thiouracil | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of EIF4G2 mRNA | CTD | PMID:30047161 | 7,12-dimethyltetraphene | affects expression | EXP | | 6480464 | 9 more ... | CTD | PMID:21785161 | acrolein | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of EIF4G2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | all-trans-retinoic acid | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | PDCD4 protein promotes the reaction [Tretinoin results in increased expression of EIF4G2 protein] and Tretinoin results in increased expression of and results in increased localization of EIF4G2 protein | CTD | PMID:17259349 and PMID:18491231 | all-trans-retinoic acid | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of EIF4G2 mRNA | CTD | PMID:18491231 | alpha-pinene | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of EIF4G2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of EIF4G2 mRNA | CTD | PMID:32699268 | amitrole | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of EIF4G2 mRNA | CTD | PMID:30047161 | arsenous acid | increases cleavage | ISO | EIF4G2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased cleavage of EIF4G2 protein | CTD | PMID:18491231 | atrazine | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Atrazine results in increased expression of EIF4G2 mRNA | CTD | PMID:22378314 | atrazine | affects methylation | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of EIF4G2 gene | CTD | PMID:28931070 | belinostat | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | belinostat results in decreased expression of EIF4G2 mRNA | CTD | PMID:19606018 | benzene | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Benzene results in increased expression of EIF4G2 mRNA | CTD | PMID:15878777 | benzo[a]pyrene | affects expression | EXP | | 6480464 | Benzo(a)pyrene affects the expression of EIF4G2 mRNA | CTD | PMID:22342234 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EIF4G2 mRNA | CTD | PMID:21932408 | bisphenol A | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EIF4G2 protein | CTD | PMID:31675489 and PMID:37567409 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EIF4G2 mRNA | CTD | PMID:33221593 | bisphenol A | affects expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of EIF4G2 mRNA | CTD | PMID:30903817 | bisphenol A | affects expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of EIF4G2 mRNA | CTD | PMID:25181051 | bisphenol F | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF4G2 mRNA | CTD | PMID:28628672 | bisphenol F | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of EIF4G2 protein | CTD | PMID:34186270 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of EIF4G2 mRNA | CTD | PMID:18974090 | calcitriol | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of EIF4G2 protein | CTD | PMID:18491231 | CGP 52608 | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EIF4G2 gene] | CTD | PMID:28238834 | cisplatin | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of EIF4G2 mRNA | CTD | PMID:25450742 | cobalt dichloride | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of EIF4G2 mRNA | CTD | PMID:19320972 | copper atom | multiple interactions | EXP | | 6480464 | MT1 affects the reaction [Copper results in increased expression of EIF4G2 mRNA] and MT2 affects the reaction [Copper results in increased expression of EIF4G2 mRNA] | CTD | PMID:16629173 | copper(0) | multiple interactions | EXP | | 6480464 | MT1 affects the reaction [Copper results in increased expression of EIF4G2 mRNA] and MT2 affects the reaction [Copper results in increased expression of EIF4G2 mRNA] | CTD | PMID:16629173 | cyproconazole | decreases expression | EXP | | 6480464 | cyproconazole results in decreased expression of EIF4G2 mRNA | CTD | PMID:22334560 | dexamethasone | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF4G2 mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases cleavage | ISO | EIF4G2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased cleavage of EIF4G2 protein | CTD | PMID:18491231 | dibenzo[a,l]pyrene | decreases expression | EXP | | 6480464 | dibenzo(a and l)pyrene results in decreased expression of EIF4G2 mRNA | CTD | PMID:25908611 | diethylstilbestrol | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Diethylstilbestrol results in decreased expression of EIF4G2 mRNA | CTD | PMID:36621641 | dimethyl sulfoxide | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Dimethyl Sulfoxide results in increased expression of EIF4G2 protein | CTD | PMID:18491231 | disodium selenite | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of EIF4G2 mRNA | CTD | PMID:18175754 | doxorubicin | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of EIF4G2 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of EIF4G2 mRNA | CTD | PMID:22334560 | ethanol | multiple interactions | EXP | | 6480464 | Ethanol affects the expression of and affects the splicing of EIF4G2 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of EIF4G2 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | EIF4G2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of EIF4G2 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of EIF4G2 mRNA | CTD | PMID:22061828 | hydrogen peroxide | affects expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of EIF4G2 mRNA | CTD | PMID:21179406 | indometacin | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF4G2 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of EIF4G2 protein | CTD | PMID:32959892 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of EIF4G2 mRNA | CTD | PMID:20542052 | LY294002 | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of EIF4G2 protein | CTD | PMID:18491231 | maneb | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA and Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] | CTD | PMID:23963992 | melatonin | multiple interactions | EXP | | 6480464 | Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] | CTD | PMID:23963992 | menadione | affects expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of EIF4G2 mRNA | CTD | PMID:20044591 | methamphetamine | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Methamphetamine results in increased expression of EIF4G2 mRNA | CTD | PMID:10336889 | methimazole | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of EIF4G2 mRNA | CTD | PMID:30047161 | methylseleninic acid | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | methylselenic acid results in decreased expression of EIF4G2 mRNA | CTD | PMID:12517777 | ozone | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of EIF4G2 mRNA more ... | CTD | PMID:32699268 more ... | p-menthan-3-ol | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Menthol results in decreased expression of EIF4G2 mRNA | CTD | PMID:26760959 | paraquat | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA and Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] | CTD | PMID:23963992 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of EIF4G2 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of EIF4G2 protein | CTD | PMID:24301089 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EIF4G2 mRNA | CTD | PMID:36331819 | phorbol 13-acetate 12-myristate | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of EIF4G2 protein | CTD | PMID:18491231 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of EIF4G2 mRNA | CTD | PMID:22334560 | resveratrol | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of EIF4G2 protein | CTD | PMID:18089832 | rimonabant | multiple interactions | EXP | | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EIF4G2 mRNA] | CTD | PMID:19030233 | sirolimus | increases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Sirolimus results in increased expression of EIF4G2 protein | CTD | PMID:18491231 | sodium arsenite | multiple interactions | ISO | EIF4G2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of and results in increased activity of EIF4G2 protein | CTD | PMID:30528433 | sulfadimethoxine | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of EIF4G2 mRNA | CTD | PMID:30047161 | thioacetamide | increases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of EIF4G2 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | titanium dioxide results in decreased expression of EIF4G2 protein | CTD | PMID:30910687 | trichostatin A | decreases expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of EIF4G2 mRNA | CTD | PMID:19606018 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of EIF4G2 mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of EIF4G2 mRNA | CTD | PMID:19136453 | valproic acid | affects expression | ISO | EIF4G2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EIF4G2 mRNA | CTD | PMID:25979313 | vinclozolin | affects expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | vinclozolin affects the expression of EIF4G2 mRNA | CTD | PMID:19015723 | vinclozolin | decreases expression | ISO | Eif4g2 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of EIF4G2 mRNA | CTD | PMID:23034163 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | The mechanism of eukaryotic translation initiation: new insights and challenges. | Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544. |
| 2. | The scanning mechanism of eukaryotic translation initiation. | Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29. |
| 3. | Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. | Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78. |
| 4. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 5. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 6. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 7. | Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. | Qian X, etal., Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1013-20. |
| 8. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 10. | Expression of the translational repressor NAT1 in experimental models of cardiac hypertrophy. | Sangaralingham SJ, etal., Mol Cell Biochem. 2003 Mar;245(1-2):183-90. |
Additional References at PubMed
| PMID:9027506 | PMID:9030685 | PMID:9049310 | PMID:9916995 | PMID:10022874 | PMID:10321731 | PMID:10349636 | PMID:10725249 | PMID:10922068 | PMID:11032820 | PMID:11042159 | PMID:11076861 |
| PMID:11217851 | PMID:11544199 | PMID:12388085 | PMID:12477932 | PMID:12482958 | PMID:12520002 | PMID:12787504 | PMID:12904583 | PMID:14610273 | PMID:14691545 | PMID:15102471 | PMID:15489334 |
| PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16602821 | PMID:18799693 | PMID:19114715 | PMID:19158098 | PMID:20843830 | PMID:21267068 | PMID:21454508 | PMID:21677750 | PMID:21689717 |
| PMID:21873635 | PMID:24194600 | PMID:24700326 | PMID:25211037 | PMID:25422881 | PMID:25737280 | PMID:27626380 | PMID:30196744 | PMID:30333137 | PMID:30718468 | PMID:31097699 | PMID:31138677 |
| PMID:32325033 | PMID:32554809 | PMID:33303185 | PMID:34321999 | PMID:36417873 | PMID:37307456 | PMID:37646610 | PMID:38355793 |
Genomics
Comparative Map Data
| Eif4g2 (Mus musculus - house mouse) |
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| EIF4G2 (Homo sapiens - human) |
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| Eif4g2 (Rattus norvegicus - Norway rat) |
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| Eif4g2 (Chinchilla lanigera - long-tailed chinchilla) |
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| EIF4G2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| EIF4G2 (Canis lupus familiaris - dog) |
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| Eif4g2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| EIF4G2 (Sus scrofa - pig) |
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| EIF4G2 (Chlorocebus sabaeus - green monkey) |
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| Eif4g2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Eif4g2
540 total Variants 
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