Lyn (LYN proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Pathways
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Gene: Lyn (LYN proto-oncogene, Src family tyrosine kinase) Heterocephalus glaber
Analyze
Symbol: Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
RGD ID: 18931550
Description: ENCODES a protein that exhibits enzyme binding (ortholog); ephrin receptor binding (ortholog); gamma-tubulin binding (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell receptor signaling pathway (ortholog); C-X-C chemokine receptor CXCR4 signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); COVID-19 (ortholog); endometriosis (ortholog); FOUND IN adherens junction (ortholog); cytoplasmic side of plasma membrane (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248864,027,178 - 4,168,902 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248864,029,318 - 4,168,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell homeostasis  (ISO)
B cell receptor signaling pathway  (ISO)
C-X-C chemokine receptor CXCR4 signaling pathway  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to heat  (ISO)
cellular response to retinoic acid  (ISO)
cytokine production  (ISO)
dendritic cell differentiation  (IEA)
DNA damage checkpoint signaling  (ISO)
DNA damage response  (IEA)
eosinophil differentiation  (ISO)
erythrocyte differentiation  (ISO)
fatty acid transport  (ISO)
Fc receptor mediated inhibitory signaling pathway  (ISO)
Fc receptor mediated stimulatory signaling pathway  (IEA)
hematopoietic progenitor cell differentiation  (ISO)
hemopoiesis  (ISO)
histamine secretion by mast cell  (ISO)
immune response-regulating cell surface receptor signaling pathway  (ISO)
innate immune response  (IEA)
interleukin-5-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of B cell proliferation  (IEA)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of intracellular signal transduction  (ISO)
negative regulation of mast cell proliferation  (IEA)
negative regulation of myeloid leukocyte differentiation  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
neuron projection development  (IEA,ISO)
oligodendrocyte development  (ISO)
platelet degranulation  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendritic cell apoptotic process  (IEA)
positive regulation of Fc receptor mediated stimulatory signaling pathway  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of B cell apoptotic process  (IEA)
regulation of B cell receptor signaling pathway  (IEA)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of cytokine production  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of erythrocyte differentiation  (ISO)
regulation of inflammatory response  (ISO)
regulation of mast cell activation  (ISO)
regulation of mast cell degranulation  (IEA)
regulation of monocyte chemotaxis  (ISO)
regulation of platelet aggregation  (IEA)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to carbohydrate  (ISO)
response to hormone  (ISO)
response to insulin  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to sterol depletion  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
tolerance induction to self antigen  (IEA)
toll-like receptor 4 signaling pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lyn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248864,027,178 - 4,168,902 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248864,029,318 - 4,168,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LYN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38855,879,835 - 56,014,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl855,879,835 - 56,014,169 (+)EnsemblGRCh38hg38GRCh38
GRCh37856,792,394 - 56,926,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36856,954,926 - 57,085,685 (+)NCBINCBI36Build 36hg18NCBI36
Build 34856,954,925 - 57,085,685NCBI
Celera852,784,229 - 52,915,775 (+)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,260,576 - 52,393,067 (+)NCBIHuRef
CHM1_1856,844,030 - 56,976,630 (+)NCBICHM1_1
T2T-CHM13v2.0856,256,887 - 56,391,325 (+)NCBIT2T-CHM13v2.0
Lyn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,676,865 - 3,791,613 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,678,115 - 3,813,122 (+)EnsemblGRCm39 Ensembl
GRCm3843,678,068 - 3,791,612 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,678,115 - 3,813,122 (+)EnsemblGRCm38mm10GRCm38
MGSCv3743,605,268 - 3,718,759 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,205,785 - 3,233,451 (+)NCBIMGSCv36mm8
MGSCv3643,605,272 - 3,718,759 (+)NCBIMGSCv36mm8
Celera43,624,290 - 3,748,767 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.05NCBI
Lyn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,437,127 - 21,553,097 (+)NCBIGRCr8
mRatBN7.2516,639,512 - 16,755,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,639,466 - 16,756,868 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx518,881,335 - 18,996,656 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0520,479,822 - 20,595,148 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,231,313 - 20,346,636 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0516,526,058 - 16,642,648 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,526,058 - 16,642,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,307,094 - 21,422,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4516,933,111 - 17,054,564 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1516,933,105 - 17,054,560 (+)NCBI
Celera516,004,013 - 16,119,589 (+)NCBICelera
RH 3.4 Map586.9RGD
Cytogenetic Map5q12NCBI
Lyn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545415,035,979 - 15,111,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545415,025,967 - 15,111,142 (+)NCBIChiLan1.0ChiLan1.0
LYN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2771,528,579 - 71,666,226 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1847,254,385 - 47,391,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0852,318,497 - 52,455,741 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1849,755,745 - 49,825,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,755,708 - 49,825,287 (+)Ensemblpanpan1.1panPan2
LYN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,367,617 - 7,448,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,332,684 - 7,448,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,646,390 - 7,761,519 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,407,120 - 7,522,482 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,407,106 - 7,522,223 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,421,443 - 7,536,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,554,220 - 7,669,329 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0297,830,951 - 7,946,216 (+)NCBIUU_Cfam_GSD_1.0
Lyn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530372,085,767 - 72,205,721 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,637,958 - 2,700,055 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364962,578,598 - 2,698,165 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LYN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,793,492 - 75,903,496 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,793,273 - 75,903,710 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,711,087 - 82,843,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LYN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1851,919,656 - 52,057,376 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl851,919,808 - 52,057,959 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,742,858 - 89,881,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000004031   ⟹   ENSHGLP00000003973
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248864,027,178 - 4,168,902 (-)Ensembl
RefSeq Acc Id: XM_004871523   ⟹   XP_004871580
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248864,029,318 - 4,168,795 (-)NCBI
RefSeq Acc Id: XM_004871524   ⟹   XP_004871581
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248864,029,318 - 4,118,857 (-)NCBI
RefSeq Acc Id: XM_004871525   ⟹   XP_004871582
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248864,029,318 - 4,168,795 (-)NCBI
RefSeq Acc Id: XM_021249544   ⟹   XP_021105203
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248864,029,318 - 4,098,466 (-)NCBI
RefSeq Acc Id: XM_021249545   ⟹   XP_021105204
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248864,032,098 - 4,168,797 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004871582   ⟸   XM_004871525
- Peptide Label: isoform X2
- UniProtKB: G5B336 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004871580   ⟸   XM_004871523
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JY89 (UniProtKB/TrEMBL),   G5B336 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004871581   ⟸   XM_004871524
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JY89 (UniProtKB/TrEMBL),   G5B336 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105203   ⟸   XM_021249544
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JY89 (UniProtKB/TrEMBL),   G5B336 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105204   ⟸   XM_021249545
- Peptide Label: isoform X3
- UniProtKB: G5B336 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000003973   ⟸   ENSHGLT00000004031


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002926 Ensembl, ENTREZGENE
  ENSHGLG00100040250 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004031 ENTREZGENE
  ENSHGLT00100046249 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Lyn_SH2 UniProtKB/TrEMBL
  Lyn_SH3 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report hgl:101696753 UniProtKB/TrEMBL
NCBI Gene Lyn ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE LYN UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JY89 ENTREZGENE, UniProtKB/TrEMBL
  G5B336 ENTREZGENE, UniProtKB/TrEMBL