PARP1 (poly(ADP-ribose) polymerase 1) - Rat Genome Database

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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Chlorocebus sabaeus
Analyze
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
RGD ID: 18565485
Description: ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN apoptotic process (ortholog); ATP generation from poly-ADP-D-ribose (ortholog); base-excision repair (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: poly [ADP-ribose] polymerase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,350,798 - 3,405,040 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660553,353,198 - 3,400,806 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
bacterial meningitis  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Carotid Artery Injuries  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
kyphosis  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neoplastic Cell Transformation  (ISO)
nephritis  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
Paralysis  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
periventricular leukomalacia  (ISO)
Plaque, Atherosclerotic  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Ischemia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vitamin A Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
ATP generation from poly-ADP-D-ribose  (ISO)
base-excision repair  (ISO)
behavioral response to cocaine  (ISO)
carbohydrate biosynthetic process  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to superoxide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to UV  (ISO)
cellular response to zinc ion  (ISO)
decidualization  (ISO)
DNA ADP-ribosylation  (ISO)
DNA damage response  (ISO)
DNA metabolic process  (ISO)
DNA repair  (ISO)
double-strand break repair  (ISO)
mitochondrial DNA metabolic process  (ISO)
mitochondrial DNA repair  (ISO)
mitochondrion organization  (ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of ATP biosynthetic process  (ISO)
negative regulation of cGAS/STING signaling pathway  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of telomere maintenance via telomere lengthening  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription elongation by RNA polymerase II  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of DNA-templated transcription, elongation  (ISO)
positive regulation of double-strand break repair via homologous recombination  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of necroptotic process  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of single strand break repair  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein auto-ADP-ribosylation  (ISO)
protein autoprocessing  (ISO)
protein localization to chromatin  (ISO)
protein modification process  (ISO)
regulation of base-excision repair  (ISO)
regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
regulation of growth rate  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of protein localization  (ISO)
regulation of single strand break repair  (ISO)
replication fork reversal  (ISO)
response to aldosterone  (ISO)
response to gamma radiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
telomere maintenance  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
voluntary musculoskeletal movement  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PARP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,350,798 - 3,405,040 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660553,353,198 - 3,400,806 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PARP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,360,691 - 226,408,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,360,210 - 226,408,154 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,548,392 - 226,595,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,615,015 - 224,662,424 (-)NCBINCBI36Build 36hg18NCBI36
Build 341222,855,240 - 222,902,526NCBI
Celera1199,739,310 - 199,786,722 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1197,065,678 - 197,113,094 (-)NCBIHuRef
CHM1_11227,821,256 - 227,868,667 (-)NCBICHM1_1
T2T-CHM13v2.01225,548,804 - 225,596,198 (-)NCBIT2T-CHM13v2.0
Parp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,396,456 - 180,428,564 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,396,489 - 180,428,819 (+)EnsemblGRCm39 Ensembl
GRCm381180,568,891 - 180,600,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,568,924 - 180,601,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,499,106 - 182,531,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,405,650 - 182,437,929 (+)NCBIMGSCv36mm8
Celera1187,634,811 - 187,667,071 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.44NCBI
Parp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81394,839,484 - 94,871,295 (+)NCBIGRCr8
mRatBN7.21392,307,593 - 92,339,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,307,586 - 92,339,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1394,812,753 - 94,844,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,212,939 - 96,244,750 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,387,644 - 93,419,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01398,857,255 - 98,889,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,857,177 - 98,889,716 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,859,760 - 103,891,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,309,670 - 96,341,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,498,605 - 96,530,421 (+)NCBI
Celera1391,853,812 - 91,885,580 (+)NCBICelera
Cytogenetic Map13q26NCBI
Parp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489520,875 - 557,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489520,875 - 557,609 (-)NCBIChiLan1.0ChiLan1.0
PARP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,130,083 - 23,178,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,078,568 - 23,126,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01201,820,355 - 201,867,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11206,812,981 - 206,860,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,812,981 - 206,860,356 (-)Ensemblpanpan1.1panPan2
PARP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,503,072 - 38,542,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,984,470 - 38,024,231 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,336,543 - 38,376,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,336,478 - 38,376,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,175,521 - 38,215,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,182,459 - 38,222,219 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,453,305 - 38,493,301 (+)NCBIUU_Cfam_GSD_1.0
Parp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,599,711 - 51,644,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365263,102,039 - 3,147,642 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365263,102,468 - 3,147,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,203,160 - 14,241,196 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,203,157 - 14,241,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,598,164 - 16,636,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Parp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624807446,647 - 479,069 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624807446,662 - 478,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007988265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_007988265   ⟹   XP_007986456
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1253,350,798 - 3,405,040 (+)NCBI
Vero_WHO_p1.0NW_0236660553,353,198 - 3,400,806 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007986456 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_007986456   ⟸   XM_007988265


Additional Information

Database Acc Id Source(s)
NCBI Gene PARP1 ENTREZGENE