Lrp1 (low density lipoprotein receptor-related protein 1) - Rat Genome Database

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Gene: Lrp1 (low density lipoprotein receptor-related protein 1) Mus musculus
Analyze
Symbol: Lrp1
Name: low density lipoprotein receptor-related protein 1
RGD ID: 1316787
MGI Page MGI
Description: Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of signal transduction; and positive regulation of transport. Acts upstream of or within several processes, including cholesterol metabolic process; endocytosis; and heart development. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A2; A2mr; AI316852; alpha 2-macroglobulin receptor; alpha-2-macroglobulin receptor; b2b1554C; b2b1554Clo; CD91; lipoprotein receptor-related protein; Lrp; LRP-1; prolow-density lipoprotein receptor-related protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,374,026 - 127,457,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,374,030 - 127,457,017 (-)EnsemblGRCm39 Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,538,161 - 127,621,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBIMGSCv36mm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-tert-butylphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
alpha-D-galactose  (EXP)
amitrole  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
BAPTA  (EXP)
benzo[a]pyrene  (EXP,ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbon nanotube  (EXP)
chlordecone  (EXP)
cholesterol  (EXP)
ciguatoxin CTX1B  (EXP)
cimetidine  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP)
clofibric acid  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diiodine  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenthion  (EXP)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (EXP)
gentamycin  (ISO)
glutathione  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (EXP)
imatinib methanesulfonate  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
KT 5720  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lipopolysaccharide  (EXP)
lucanthone  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methidathion  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
miconazole  (EXP)
microcystin-LR  (EXP)
monosodium L-glutamate  (EXP)
morphine  (EXP)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
niclosamide  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
senecionine  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triprolidine  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IMP)
amyloid-beta clearance by cellular catabolic process  (IBA,IDA,IGI,IMP,ISO)
amyloid-beta clearance by transcytosis  (IBA,IDA,ISO)
aorta morphogenesis  (IMP)
apoptotic cell clearance  (IMP)
astrocyte activation involved in immune response  (IGI)
cardiac septum development  (IMP)
cellular lipid catabolic process  (ISO)
cellular response to amyloid-beta  (IGI)
cerebral cortex development  (ISO)
chemoattraction of axon  (ISO)
cholesterol metabolic process  (IMP)
coronary vasculature development  (IMP)
endocytosis  (IEA)
enzyme-linked receptor protein signaling pathway  (IMP)
lysosomal transport  (IDA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (IMP)
negative regulation of SMAD protein signal transduction  (IMP)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of transforming growth factor beta receptor signaling pathway  (IGI)
negative regulation of Wnt signaling pathway  (IDA)
phagocytosis  (IBA,ISO)
positive regulation of amyloid-beta clearance  (IMP)
positive regulation of axon extension  (ISO)
positive regulation of axon extension involved in regeneration  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of cholesterol efflux  (IMP)
positive regulation of cholesterol import  (ISO)
positive regulation of collateral sprouting of injured axon  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of lipid transport  (IMP)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein transport  (ISO)
positive regulation of Schwann cell migration  (ISO)
positive regulation of transcytosis  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
receptor-mediated endocytosis  (IBA,IDA,IGI,IMP,ISO)
regulation of actin cytoskeleton organization  (IMP)
regulation of cholesterol transport  (IMP)
regulation of postsynaptic neurotransmitter receptor internalization  (EXP,IDA,IMP)
regulation of pulmonary blood vessel remodeling  (IMP)
transport across blood-brain barrier  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abdominal aorta aneurysm  (IAGP)
abnormal adipose tissue amount  (IAGP)
abnormal adipose tissue physiology  (IAGP)
abnormal aorta elastic tissue morphology  (IAGP)
abnormal aorta smooth muscle morphology  (IAGP)
abnormal aorta tunica media morphology  (IAGP)
abnormal ascending aorta morphology  (IAGP)
abnormal associative learning  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal body temperature homeostasis  (IAGP)
abnormal body wall morphology  (IEA)
abnormal brown fat cell morphology  (IAGP)
abnormal cholesterol level  (IAGP)
abnormal circulating apolipoprotein E level  (IAGP)
abnormal circulating apolipoprotein level  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal embryo size  (IEA)
abnormal fat pad morphology  (IAGP)
abnormal forebrain morphology  (IEA)
abnormal gait  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart ventricle outflow tract morphology  (IEA)
abnormal limb bud morphology  (IEA)
abnormal limb posture  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver perisinusoidal space morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal posture  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
amyloid beta deposits  (IAGP)
aortic aneurysm  (IAGP)
aortic valve regurgitation  (IAGP)
artery occlusion  (IAGP)
astrocytosis  (IAGP)
atherosclerotic lesions  (IAGP)
atrioventricular septal defect  (IEA)
brain inflammation  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cerebral amyloid angiopathy  (IAGP)
decreased body surface temperature  (IAGP)
decreased body weight  (IAGP)
decreased brain cholesterol level  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased brown fat cell size  (IAGP)
decreased brown fat lipid droplet number  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased dendritic spine density  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased hepatocyte number  (IAGP)
decreased interscapular fat pad weight  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
decreased triglyceride level  (IAGP)
decreased vasoconstriction  (IAGP)
decreased white fat cell size  (IAGP)
diaphragmatic hernia  (IEA)
dilated aorta  (IAGP)
dilated aorta bulb  (IAGP)
dilated ascending aorta  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IAGP)
hemorrhage  (IEA)
herniated abdominal wall  (IEA)
hyperactivity  (IAGP)
hypoglycemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired limb coordination  (IAGP)
impaired macrophage phagocytosis  (IAGP)
improved glucose tolerance  (IAGP)
increased aorta wall thickness  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating cholesterol level  (IAGP)
increased circulating factor VIII level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased circulating von Willebrand factor level  (IAGP)
increased energy expenditure  (IAGP)
increased food intake  (IAGP)
increased heart left ventricle size  (IAGP)
increased heart weight  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased oxygen consumption  (IAGP)
increased pulse pressure  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased vascular smooth muscle cell proliferation  (IAGP)
internal hemorrhage  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
limb grasping  (IAGP)
liver degeneration  (IAGP)
microphthalmia  (IEA)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
omphalocele  (IEA)
perinatal lethality, complete penetrance  (IAGP)
perivascular fibrosis  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced fertility  (IAGP)
reduced long-term potentiation  (IAGP)
tremors  (IAGP)
trunk curl  (IAGP)
weakness  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Espirito Santo SM, etal., Blood. 2004 May 15;103(10):3777-82. Epub 2004 Jan 22.
2. Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells. Fred RG, etal., Clin Sci (Lond). 2015 Jan;128(1):17-28. doi: 10.1042/CS20130560.
3. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. Gaultier A, etal., J Cell Sci. 2009 Apr 15;122(Pt 8):1155-62. doi: 10.1242/jcs.040717. Epub 2009 Mar 19.
4. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. Gaultier A, etal., J Clin Invest. 2008 Jan;118(1):161-72. doi: 10.1172/JCI32371.
5. Decreased expression of the low-density lipoprotein receptor-related protein-1 (LRP-1) in rats with prostate cancer. Gilardoni MB, etal., J Histochem Cytochem. 2003 Dec;51(12):1575-80.
6. Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. Hu K, etal., J Clin Invest. 2007 Dec;117(12):3821-32.
7. Effect of Linguizhugan decoction on neuroinflammation and expression disorder of the amyloid ß-related transporters RAGE and LRP-1 in a rat model of Alzheimer's disease. Hu Q, etal., Mol Med Rep. 2018 Jan;17(1):827-834. doi: 10.3892/mmr.2017.7983. Epub 2017 Nov 6.
8. Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Kang LI, etal., Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.
9. Association at LRP gene locus with sporadic late-onset Alzheimer's disease. Lambert JC, etal., Lancet 1998 Jun 13;351(9118):1787-8.
10. Altered expression of Abeta metabolism-associated molecules from D-galactose/AlCl(3) induced mouse brain. Luo Y, etal., Mech Ageing Dev. 2009 Apr;130(4):248-52. doi: 10.1016/j.mad.2008.12.005. Epub 2008 Dec 27.
11. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. May P, etal., Mol Cell Biol 2004 Oct;24(20):8872-83.
12. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. McCarthy JJ, etal., J Med Genet. 2004 May;41(5):334-41.
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Upregulation of hepatic LRP1 by rosiglitazone: a possible novel mechanism of the beneficial effect of thiazolidinediones on atherogenic dyslipidemia. Moon JH, etal., J Mol Endocrinol. 2012 Oct 10;49(3):165-74. doi: 10.1530/JME-12-0119. Print 2012 Dec.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Overton CD, etal., Circ Res. 2007 Mar 16;100(5):670-7. Epub 2007 Feb 15.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization. Sanchez MC, etal., Exp Eye Res. 2006 Dec;83(6):1378-85. Epub 2006 Sep 15.
24. The LDL receptor-related protein (LRP1/A2MR) and coronary atherosclerosis--novel genomic variants and functional consequences. Schulz S, etal., Hum Mutat. 2002 Nov;20(5):404.
25. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
26. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. Yoon C, etal., J Biol Chem. 2013 Sep 13;288(37):26557-68. doi: 10.1074/jbc.M113.478552. Epub 2013 Jul 18.
Additional References at PubMed
PMID:1377168   PMID:1423604   PMID:1698775   PMID:1702392   PMID:3266596   PMID:7514554   PMID:7524394   PMID:7542371   PMID:7544347   PMID:7595098   PMID:7829084   PMID:8013374  
PMID:8485155   PMID:8490961   PMID:8798151   PMID:9449704   PMID:9634821   PMID:9733098   PMID:9788969   PMID:10349636   PMID:10380922   PMID:10482304   PMID:10575007   PMID:10772929  
PMID:10827173   PMID:10922068   PMID:11042159   PMID:11067868   PMID:11076861   PMID:11208732   PMID:11217851   PMID:11248808   PMID:11729193   PMID:11867643   PMID:11971949   PMID:12151109  
PMID:12169628   PMID:12413896   PMID:12477932   PMID:12499359   PMID:12522008   PMID:12531796   PMID:12598530   PMID:12690199   PMID:12746448   PMID:12821648   PMID:12857755   PMID:12871934  
PMID:12904583   PMID:14522960   PMID:14593097   PMID:14610273   PMID:14617754   PMID:14699139   PMID:15082773   PMID:15135046   PMID:15226301   PMID:15327526   PMID:15389876   PMID:15647754  
PMID:15753096   PMID:15840700   PMID:15944146   PMID:15963947   PMID:16141072   PMID:16141073   PMID:16149055   PMID:16207730   PMID:16303771   PMID:16382151   PMID:16407289   PMID:16478678  
PMID:16601674   PMID:16930548   PMID:16936287   PMID:17012232   PMID:17038633   PMID:17055779   PMID:17065459   PMID:17075973   PMID:17080197   PMID:17124247   PMID:17154366   PMID:17170123  
PMID:17389516   PMID:17409116   PMID:17485468   PMID:17505534   PMID:17570828   PMID:17711877   PMID:17727637   PMID:17908054   PMID:17920016   PMID:17947714   PMID:17948131   PMID:17958748  
PMID:18266273   PMID:18287559   PMID:18316405   PMID:18367731   PMID:18369152   PMID:18403601   PMID:18566402   PMID:18602448   PMID:18628488   PMID:18653767   PMID:18799693   PMID:18804458  
PMID:18834984   PMID:18940800   PMID:18990694   PMID:18992221   PMID:19005074   PMID:19036715   PMID:19047013   PMID:19066283   PMID:19098903   PMID:19115269   PMID:19147818   PMID:19251705  
PMID:19285094   PMID:19299737   PMID:19455133   PMID:19539695   PMID:19586665   PMID:19605848   PMID:19608750   PMID:19667105   PMID:19672275   PMID:19699300   PMID:19718435   PMID:19729608  
PMID:19742316   PMID:19771558   PMID:19796621   PMID:19815552   PMID:19823686   PMID:19855143   PMID:19856143   PMID:19858221   PMID:19864425   PMID:19947650   PMID:20048341   PMID:20150557  
PMID:20205790   PMID:20360257   PMID:20472562   PMID:20568116   PMID:20610799   PMID:20630619   PMID:20686698   PMID:20919742   PMID:20920479   PMID:21048103   PMID:21159977   PMID:21252237  
PMID:21258337   PMID:21264353   PMID:21267068   PMID:21289173   PMID:21337463   PMID:21343303   PMID:21383009   PMID:21454706   PMID:21540184   PMID:21676865   PMID:21677750   PMID:21683247  
PMID:21730304   PMID:21795536   PMID:21873635   PMID:21995440   PMID:22027709   PMID:22174911   PMID:22203668   PMID:22234691   PMID:22238606   PMID:22308347   PMID:22422887   PMID:22454363  
PMID:22467855   PMID:22511630   PMID:22537779   PMID:22674573   PMID:22701627   PMID:22739378   PMID:22777006   PMID:23152628   PMID:23264627   PMID:23283348   PMID:23382219   PMID:23517243  
PMID:23536074   PMID:23580652   PMID:23593972   PMID:23615909   PMID:23633492   PMID:23675525   PMID:23676495   PMID:23760271   PMID:23846497   PMID:23866919   PMID:23868935   PMID:23959870  
PMID:23963646   PMID:23986861   PMID:24129569   PMID:24194600   PMID:24251389   PMID:24305823   PMID:24312398   PMID:24440681   PMID:24469637   PMID:24504736   PMID:24509082   PMID:24639464  
PMID:24737893   PMID:24747018   PMID:24778318   PMID:24952961   PMID:25050824   PMID:25075518   PMID:25131634   PMID:25301084   PMID:25377550   PMID:25395615   PMID:25486042   PMID:25500815  
PMID:25546260   PMID:25670857   PMID:25693689   PMID:25694133   PMID:25728415   PMID:25786328   PMID:25807483   PMID:25855193   PMID:25937287   PMID:25954050   PMID:25968337   PMID:26005850  
PMID:26061292   PMID:26263173   PMID:26370502   PMID:26453377   PMID:26610862   PMID:26619118   PMID:26634655   PMID:26688581   PMID:26787872   PMID:26792864   PMID:26820600   PMID:27163530  
PMID:27181517   PMID:27258849   PMID:27280679   PMID:27317662   PMID:27322467   PMID:27365402   PMID:27400128   PMID:27400748   PMID:27503326   PMID:27507650   PMID:27522265   PMID:27614059  
PMID:27626380   PMID:27931217   PMID:28263310   PMID:28275161   PMID:28378397   PMID:28378742   PMID:28393867   PMID:28424516   PMID:28473440   PMID:28495363   PMID:28496400   PMID:28516428  
PMID:28596374   PMID:28604703   PMID:28671696   PMID:28684538   PMID:28710453   PMID:28867180   PMID:28972143   PMID:29116364   PMID:29144234   PMID:29251594   PMID:29326120   PMID:29457786  
PMID:29520865   PMID:29750835   PMID:29752404   PMID:29773651   PMID:29794082   PMID:30061663   PMID:30100244   PMID:30209191   PMID:30340601   PMID:30354243   PMID:30420518   PMID:30458112  
PMID:30518764   PMID:30550785   PMID:30647120   PMID:30647151   PMID:30700132   PMID:30741718   PMID:30746765   PMID:30904610   PMID:30944251   PMID:31004319   PMID:31023188   PMID:31552482  
PMID:31841706   PMID:31936892   PMID:31964526   PMID:32112822   PMID:32251761   PMID:32325033   PMID:32349534   PMID:32546759   PMID:32554809   PMID:32572761   PMID:32579270   PMID:32645395  
PMID:32786820   PMID:32964988   PMID:33290178   PMID:33356995   PMID:33500241   PMID:33533918   PMID:33548224   PMID:33762741   PMID:33784254   PMID:34147102   PMID:34168225   PMID:34298914  
PMID:34321999   PMID:34445520   PMID:34489478   PMID:34529485   PMID:34559985   PMID:34709266   PMID:34758632   PMID:34810220   PMID:34910922   PMID:34988124   PMID:35143327   PMID:35202607  
PMID:35392093   PMID:35634664   PMID:35939689   PMID:36028175   PMID:36035210   PMID:36056345   PMID:36067312   PMID:36067928   PMID:36266319   PMID:36307211   PMID:36394710   PMID:36472907  
PMID:36973740   PMID:37020553   PMID:37036005   PMID:37060729   PMID:37072184   PMID:37107705   PMID:37186298   PMID:37335131   PMID:37408279   PMID:37450601   PMID:37724952   PMID:38041876  
PMID:38063014   PMID:38123547  


Genomics

Comparative Map Data
Lrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,374,026 - 127,457,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,374,030 - 127,457,017 (-)EnsemblGRCm39 Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,538,161 - 127,621,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBIMGSCv36mm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.52NCBI
LRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,128,483 - 57,213,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,128,483 - 57,213,361 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,522,266 - 57,607,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,808,549 - 55,893,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,808,548 - 55,893,390NCBI
Celera1257,176,220 - 57,261,424 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,625,579 - 54,646,229 (+)NCBIHuRef
HuRef1254,560,642 - 54,624,427 (+)NCBIHuRef
CHM1_11257,489,966 - 57,575,252 (+)NCBICHM1_1
T2T-CHM13v2.01257,096,318 - 57,181,610 (+)NCBIT2T-CHM13v2.0
Lrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,265,639 - 65,346,196 (-)NCBIGRCr8
mRatBN7.2763,380,325 - 63,461,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,380,356 - 63,460,910 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,269,622 - 65,350,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,472,045 - 67,552,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,273,181 - 67,353,771 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
Lrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,861,431 - 4,941,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,861,431 - 4,941,939 (+)NCBIChiLan1.0ChiLan1.0
LRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,128,926 - 37,215,816 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,124,986 - 37,210,395 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,713,938 - 31,799,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,966,149 - 32,051,979 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,966,149 - 32,051,979 (-)Ensemblpanpan1.1panPan2
LRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,260,256 - 1,341,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,260,719 - 1,352,271 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,324,330 - 1,405,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,270,934 - 1,352,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,270,727 - 1,352,186 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,247,639 - 1,328,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,489,631 - 1,570,787 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,614,746 - 1,695,694 (+)NCBIUU_Cfam_GSD_1.0
Lrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,463,638 - 57,543,337 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,327,374 - 1,406,456 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,326,900 - 1,407,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1522,435,636 - 22,519,276 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,186,409 - 24,202,094 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,039,147 - 53,125,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,039,364 - 53,125,776 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,847,266 - 192,933,317 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,734,263 - 10,812,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,734,907 - 10,812,888 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp1
2545 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2319
Count of miRNA genes:803
Interacting mature miRNAs:1094
Transcripts:ENSMUST00000049149, ENSMUST00000118455, ENSMUST00000121829, ENSMUST00000125480, ENSMUST00000129727, ENSMUST00000129877, ENSMUST00000133620, ENSMUST00000135188, ENSMUST00000140269, ENSMUST00000145947
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse

Markers in Region
Lrp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B2-D1UniSTS
cM Map10 UniSTS
RH136136  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,538,578 - 127,538,770UniSTSGRCm38
MGSCv3710126,975,634 - 126,975,826UniSTSGRCm37
Celera10129,930,428 - 129,930,620UniSTS
Cytogenetic Map10B2-D1UniSTS
RH132158  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,538,357 - 127,538,560UniSTSGRCm38
MGSCv3710126,975,413 - 126,975,616UniSTSGRCm37
Celera10129,930,207 - 129,930,410UniSTS
Cytogenetic Map10B2-D1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC167719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF367720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU615020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA888999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB527265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF535491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000049149   ⟹   ENSMUSP00000044004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,374,030 - 127,457,017 (-)Ensembl
GRCm38.p6 Ensembl10127,538,161 - 127,621,148 (-)Ensembl
RefSeq Acc Id: ENSMUST00000118455   ⟹   ENSMUSP00000113497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,435,753 - 127,456,791 (-)Ensembl
GRCm38.p6 Ensembl10127,599,884 - 127,620,922 (-)Ensembl
RefSeq Acc Id: ENSMUST00000121829   ⟹   ENSMUSP00000113584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,425,025 - 127,456,839 (-)Ensembl
GRCm38.p6 Ensembl10127,589,156 - 127,620,970 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,423,496 - 127,457,017 (-)Ensembl
GRCm38.p6 Ensembl10127,587,627 - 127,621,148 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129727   ⟹   ENSMUSP00000120567
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,382,264 - 127,385,786 (-)Ensembl
GRCm38.p6 Ensembl10127,546,395 - 127,549,917 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,414,198 - 127,417,754 (-)Ensembl
GRCm38.p6 Ensembl10127,578,329 - 127,581,885 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133620   ⟹   ENSMUSP00000115305
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,417,598 - 127,419,329 (-)Ensembl
GRCm38.p6 Ensembl10127,581,729 - 127,583,460 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,374,468 - 127,375,466 (-)Ensembl
GRCm38.p6 Ensembl10127,538,599 - 127,539,597 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140269
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,375,104 - 127,376,011 (-)Ensembl
GRCm38.p6 Ensembl10127,539,235 - 127,540,142 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145947
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,378,065 - 127,379,077 (-)Ensembl
GRCm38.p6 Ensembl10127,542,196 - 127,543,208 (-)Ensembl
RefSeq Acc Id: NM_008512   ⟹   NP_032538
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,374,026 - 127,457,017 (-)NCBI
GRCm3810127,538,157 - 127,621,148 (-)ENTREZGENE
MGSCv3710126,975,213 - 127,058,204 (-)RGD
Celera10129,930,007 - 130,012,542 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036155650   ⟹   XP_036011543
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,374,026 - 127,457,158 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032538   ⟸   NM_008512
- Peptide Label: precursor
- UniProtKB: Q920Y4 (UniProtKB/Swiss-Prot),   Q61291 (UniProtKB/Swiss-Prot),   Q91ZX7 (UniProtKB/Swiss-Prot),   A0A0R4J0I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113497   ⟸   ENSMUST00000118455
RefSeq Acc Id: ENSMUSP00000044004   ⟸   ENSMUST00000049149
RefSeq Acc Id: ENSMUSP00000120567   ⟸   ENSMUST00000129727
RefSeq Acc Id: ENSMUSP00000115305   ⟸   ENSMUST00000133620
RefSeq Acc Id: ENSMUSP00000113584   ⟸   ENSMUST00000121829
RefSeq Acc Id: XP_036011543   ⟸   XM_036155650
- Peptide Label: isoform X1
- UniProtKB: Q920Y4 (UniProtKB/Swiss-Prot),   Q91ZX7 (UniProtKB/Swiss-Prot),   Q61291 (UniProtKB/Swiss-Prot)
Protein Domains
EGF-like   LDL-receptor class A

Promoters
RGD ID:6819540
Promoter ID:MM_KWN:5909
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000078876,   OTTMUST00000078877
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,976,756 - 126,978,057 (-)MPROMDB
RGD ID:6819539
Promoter ID:MM_KWN:5910
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   MEF_B6
Transcripts:OTTMUST00000078875
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,979,776 - 126,980,417 (-)MPROMDB
RGD ID:6848574
Promoter ID:MM_TRO:1264
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung
Transcripts:MTR019863.10.2400.5
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,981,394 - 126,981,894 (-)MPROMDB
RGD ID:6846736
Promoter ID:MM_ACW:6344
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Lung
Transcripts:LRP1.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,982,456 - 126,983,512 (-)MPROMDB
RGD ID:6819536
Promoter ID:MM_KWN:5911
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Lung
Transcripts:OTTMUST00000078874
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,987,001 - 126,987,501 (-)MPROMDB
RGD ID:6848570
Promoter ID:MM_TRO:1265
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   MEF_B6
Transcripts:MTR019863.10.2400.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,996,976 - 126,997,877 (-)MPROMDB
RGD ID:6819538
Promoter ID:MM_KWN:5912
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Lung
Transcripts:OTTMUST00000078873
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,018,626 - 127,019,907 (-)MPROMDB
RGD ID:6819537
Promoter ID:MM_KWN:5913
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000078871
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,020,106 - 127,021,192 (-)MPROMDB
RGD ID:6846740
Promoter ID:MM_ACW:6346
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:LRP1.MSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,025,011 - 127,025,712 (-)MPROMDB
RGD ID:6846737
Promoter ID:MM_ACW:6347
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B6
Transcripts:LRP1.JSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,028,821 - 127,029,527 (-)MPROMDB
RGD ID:6819534
Promoter ID:MM_KWN:5915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000118455,   NM_008512,   OTTMUST00000078869,   OTTMUST00000078872,   UC007HJZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,057,851 - 127,058,972 (-)MPROMDB
RGD ID:8673520
Promoter ID:EPDNEW_M14790
Type:initiation region
Name:Lrp1_2
Description:Mus musculus low density lipoprotein receptor-related protein1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14791  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,620,989 - 127,621,049EPDNEW
RGD ID:8673522
Promoter ID:EPDNEW_M14791
Type:initiation region
Name:Lrp1_1
Description:Mus musculus low density lipoprotein receptor-related protein1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14790  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,621,148 - 127,621,208EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96828 AgrOrtholog
Ensembl Genes ENSMUSG00000040249 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049149 ENTREZGENE
  ENSMUST00000049149.15 UniProtKB/TrEMBL
  ENSMUST00000118455.2 UniProtKB/TrEMBL
  ENSMUST00000121829.8 UniProtKB/TrEMBL
  ENSMUST00000129727.2 UniProtKB/TrEMBL
  ENSMUST00000133620.2 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type module UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16971 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96828 ENTREZGENE
NCBI Gene 16971 ENTREZGENE
PANTHER ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 UniProtKB/TrEMBL
  NEUROGENIC LOCUS PROTEIN DELTA UniProtKB/TrEMBL
  NOTCH LIGAND FAMILY MEMBER UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp1 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0I9 ENTREZGENE, UniProtKB/TrEMBL
  D3Z5M3_MOUSE UniProtKB/TrEMBL
  F6UAC8_MOUSE UniProtKB/TrEMBL
  F6XU19_MOUSE UniProtKB/TrEMBL
  LRP1_MOUSE UniProtKB/Swiss-Prot
  Q3U454_MOUSE UniProtKB/TrEMBL
  Q3U5J2_MOUSE UniProtKB/TrEMBL
  Q61291 ENTREZGENE
  Q811K6_MOUSE UniProtKB/TrEMBL
  Q8C4T5_MOUSE UniProtKB/TrEMBL
  Q91ZX7 ENTREZGENE
  Q920Y4 ENTREZGENE
UniProt Secondary Q61291 UniProtKB/Swiss-Prot
  Q920Y4 UniProtKB/Swiss-Prot