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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316787
Species: Mus musculus
RGD Object: Gene
Symbol: Lrp1
Name: low density lipoprotein receptor-related protein 1
Acc ID: CHEBI:8502
Term: 6-propyl-2-thiouracil
Definition: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
Chemical ID: MESH:D011441
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp1multiple interactionsEXP 6480464CTD[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of LRP1 protein; Triiodothyronine inhibits the reaction [[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of LRP1 protein]PMID:23517243
Lrp1decreases expressionISOLrp1 (Rattus norvegicus)6480464CTDPropylthiouracil results in decreased expression of LRP1 mRNAPMID:30047161
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