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GENE - TERM ANNOTATION REPORT

RGD ID: 1316787
Species: Mus musculus
RGD Object: Gene
Symbol: Lrp1
Name: low density lipoprotein receptor-related protein 1
Acc ID: GO:0006898
Term: receptor-mediated endocytosis
Definition: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
Definition Source(s): GOC:mah, ISBN:0716731363
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp1 ISOLrp1 (Rattus norvegicus)9068941RGD PMID:18285446 REF_RGD_ID:13800558
Lrp1involved_inIGIUniProtKB:P05067 and UniProtKB:P497682290270ARUK-UCL MGI:5529723 PMID:24305823

MGI:5529723 PMID:24305823
Lrp1involved_inIGIUniProtKB:Q057932290270ARUK-UCL MGI:5897551 PMID:21289173

MGI:5897551 PMID:21289173
Lrp1involved_inIMP 2290270ARUK-UCL MGI:5897551 PMID:21289173

MGI:5897551 PMID:21289173
Lrp1involved_inIBAPANTHER:PTN002800257 or UniProtKB:Q07954 or Lrp1 (Rattus norvegicus) or MGI:968282290270GO_Central GO_REF:0000033
Lrp1acts_upstream_of_or_withinIDA 2290270MGI PMID:21795536

PMID:21795536
Lrp1involved_inISOLrp1 (Rattus norvegicus)2290270MGI GO_REF:0000096 MGI:4417868
Lrp1involved_inISOUniProtKB:Q079542290270MGI GO_REF:0000119 MGI:4834177
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