ACTB (actin beta) - Rat Genome Database

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Gene: ACTB (actin beta) Canis lupus familiaris
Analyze
Symbol: ACTB
Name: actin beta
RGD ID: 12261807
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); identical protein binding (ortholog); kinesin binding (ortholog); INVOLVED IN adherens junction assembly (ortholog); apical protein localization (ortholog); axonogenesis (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; INO80 family mediated chromatin remodeling pathway; mitochondria transport pathway; ASSOCIATED WITH Aminoacylase 1 Deficiency (ortholog); Animal Mammary Neoplasms (ortholog); Baraitser-Winter syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); adherens junction (ortholog); apical junction complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin, cytoplasmic 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1612,421,006 - 12,424,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl612,418,932 - 12,462,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,893,047 - 13,896,436 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0612,557,673 - 12,561,075 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl612,557,667 - 12,561,086 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1612,367,765 - 12,371,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0612,301,595 - 12,304,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0612,578,988 - 12,582,384 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:8855304   PMID:15834686   PMID:35373395  


Genomics

Comparative Map Data
ACTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1612,421,006 - 12,424,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl612,418,932 - 12,462,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,893,047 - 13,896,436 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0612,557,673 - 12,561,075 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl612,557,667 - 12,561,086 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1612,367,765 - 12,371,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0612,301,595 - 12,304,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0612,578,988 - 12,582,384 (+)NCBIUU_Cfam_GSD_1.0
ACTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3875,527,148 - 5,530,601 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl75,526,409 - 5,563,902 (-)EnsemblGRCh38hg38GRCh38
GRCh3775,566,779 - 5,570,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,533,312 - 5,536,747 (-)NCBINCBI36Build 36hg18NCBI36
Build 3475,340,026 - 5,343,462NCBI
Celera75,526,560 - 5,530,009 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef75,479,343 - 5,482,774 (-)NCBIHuRef
CHM1_175,566,362 - 5,569,815 (-)NCBICHM1_1
T2T-CHM13v2.075,644,671 - 5,648,124 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v275,613,124 - 5,616,577 (-)NCBI
Actb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395142,888,870 - 142,892,509 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5142,888,870 - 142,892,509 (-)EnsemblGRCm39 Ensembl
GRCm385142,903,115 - 142,907,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5142,903,115 - 142,906,754 (-)EnsemblGRCm38mm10GRCm38
MGSCv375143,664,795 - 143,668,403 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,168,256 - 143,171,864 (-)NCBIMGSCv36mm8
Celera5139,951,533 - 139,955,141 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map581.8NCBI
Actb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,776,664 - 16,779,634 (+)NCBIGRCr8
mRatBN7.21211,663,112 - 11,666,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,663,109 - 11,672,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,473,135 - 12,476,105 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,096,401 - 13,099,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,127,796 - 12,130,766 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,715,843 - 13,718,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,715,843 - 13,718,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,745,856 - 15,749,440 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,047,070 - 12,050,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,076,997 - 12,079,967 (+)NCBI
Celera1213,452,443 - 13,455,413 (+)NCBICelera
Cytogenetic Map12p11NCBI
Actb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546010,356,699 - 10,361,585 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546010,358,100 - 10,361,585 (-)NCBIChiLan1.0ChiLan1.0
ACTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2610,493,693 - 10,497,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1758,818,394 - 58,821,932 (-)NCBINHGRI_mPanPan1
Actb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344140,675,973 - 140,679,567 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936765667,053 - 670,672 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936765667,107 - 670,627 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,082,216 - 4,090,356 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,084,275 - 4,090,383 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.234,729,278 - 4,732,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12816,195,676 - 16,197,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1252,426,752 - 52,427,879 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660905,777,528 - 5,781,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474028,087,736 - 28,090,512 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474028,087,051 - 28,090,359 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACTB
139 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 4 2 1
Medium 1 5 22 6 4 6 6 6 12 8 9 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000025413   ⟹   ENSCAFP00000023597
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl612,418,932 - 12,424,449 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049223   ⟹   ENSCAFP00000037954
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl612,421,055 - 12,424,375 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063542   ⟹   ENSCAFP00000059847
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl612,421,875 - 12,462,845 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845024003   ⟹   ENSCAFP00845018851
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl612,557,667 - 12,561,086 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845024035   ⟹   ENSCAFP00845018878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl612,558,496 - 12,561,086 (+)Ensembl
RefSeq Acc Id: NM_001195845   ⟹   NP_001182774
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1612,421,052 - 12,424,449 (+)NCBI
Dog10K_Boxer_Tasha613,893,047 - 13,896,436 (+)NCBI
ROS_Cfam_1.0612,557,673 - 12,561,075 (+)NCBI
UMICH_Zoey_3.1612,367,765 - 12,371,152 (+)NCBI
UNSW_CanFamBas_1.0612,301,595 - 12,304,986 (+)NCBI
UU_Cfam_GSD_1.0612,578,988 - 12,582,384 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001182774   ⟸   NM_001195845
- UniProtKB: Q8SPX4 (UniProtKB/Swiss-Prot),   Q11209 (UniProtKB/Swiss-Prot),   Q95164 (UniProtKB/Swiss-Prot),   O18840 (UniProtKB/Swiss-Prot),   A0A8C0K7Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023597   ⟸   ENSCAFT00000025413
RefSeq Acc Id: ENSCAFP00000037954   ⟸   ENSCAFT00000049223
RefSeq Acc Id: ENSCAFP00000059847   ⟸   ENSCAFT00000063542
RefSeq Acc Id: ENSCAFP00845018851   ⟸   ENSCAFT00845024003
RefSeq Acc Id: ENSCAFP00845018878   ⟸   ENSCAFT00845024035

Promoters
RGD ID:13683571
Promoter ID:EPDNEW_C1640
Type:initiation region
Name:ACTB_1
Description:Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1612,421,860 - 12,421,920EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016020 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030015381 UniProtKB/Swiss-Prot
  ENSCAFG00040015695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805000771 UniProtKB/Swiss-Prot
  ENSCAFG00845013473 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025413.6 UniProtKB/TrEMBL
  ENSCAFT00000095294.1 UniProtKB/Swiss-Prot
  ENSCAFT00000096462.1 UniProtKB/TrEMBL
  ENSCAFT00000103378.1 UniProtKB/TrEMBL
  ENSCAFT00030028371.1 UniProtKB/Swiss-Prot
  ENSCAFT00040028851.1 UniProtKB/TrEMBL
  ENSCAFT00040028912.1 UniProtKB/TrEMBL
  ENSCAFT00040028964.1 UniProtKB/Swiss-Prot
  ENSCAFT00805001309 UniProtKB/Swiss-Prot
  ENSCAFT00845024003 ENTREZGENE
  ENSCAFT00845024003.1 UniProtKB/TrEMBL
  ENSCAFT00845024035.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403580 UniProtKB/Swiss-Prot
NCBI Gene ACTB ENTREZGENE
PANTHER ACTIN, ALPHA CARDIAC MUSCLE 2 UniProtKB/TrEMBL
  ACTIN, CYTOPLASMIC 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTIN-42A-RELATED UniProtKB/TrEMBL
  ACTIN-RELATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR11937 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACTINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0K7Y1 ENTREZGENE
  A0A8C0ST59_CANLF UniProtKB/TrEMBL
  A0A8C0YZ88_CANLF UniProtKB/TrEMBL
  A0A8I3NEJ7_CANLF UniProtKB/TrEMBL
  A0A8I3S044_CANLF UniProtKB/TrEMBL
  A0A8P0PP07_CANLF UniProtKB/TrEMBL
  A0A8P0SK61_CANLF UniProtKB/TrEMBL
  A0A8P0TNJ6_CANLF UniProtKB/TrEMBL
  ACTB_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q11209 ENTREZGENE
  Q8SPX4 ENTREZGENE
  Q95164 ENTREZGENE
UniProt Secondary Q11209 UniProtKB/Swiss-Prot
  Q8SPX4 UniProtKB/Swiss-Prot
  Q95164 UniProtKB/Swiss-Prot
VGNC ID VGNC:111328 ENTREZGENE