RGD Reference Report - The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. - Rat Genome Database

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The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics.

Authors: Watanabe, S  Peterson, CL 
Citation: Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.
RGD ID: 9495926
Pubmed: PMID:21502417   (View Abstract at PubMed)
DOI: DOI:10.1101/sqb.2010.75.063   (Journal Full-text)

The evolutionarily conserved INO80 family of ATP-dependent chromatin-remodeling enzymes has roles in many nuclear processes, including transcription, DNA repair, and DNA replication. Here, we discuss the in vivo and in vitro properties of these enzymes, focusing on recent studies which suggest that members of this family govern the deposition and removal of the histone variant H2A.Z.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
INO80 family mediated chromatin remodeling pathway  TAS 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOACTB (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOACTL6A (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOACTR5 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOACTR6 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOACTR8 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOBRD8 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISODMAP1 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOEP400 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOEPC1 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOEPC2 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOING3 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOINO80 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOINO80B (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOINO80C (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOINO80D (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOINO80E (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOKAT5 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOMCRS1 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOMEAF6 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOMORF4L1 (Homo sapiens)9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOMORF4L2 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOMRGBP (Homo sapiens)9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISONFRKB (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISORUVBL1 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISORUVBL2 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOSRCAP (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOTFPT (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOTRRAP (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOUCHL5 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOVPS72 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOYEATS4 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOYY1 (Homo sapiens)9495926; 9495926 RGD 
INO80 family mediated chromatin remodeling pathway  ISOZNHIT1 (Homo sapiens)9495926; 9495926 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Actb  (actin, beta)
Actl6a  (actin-like 6A)
Actr5  (actin related protein 5)
Actr6  (actin related protein 6)
Actr8  (actin related protein 8)
Brd8  (bromodomain containing 8)
Dmap1  (DNA methyltransferase 1-associated protein 1)
Ep400  (E1A binding protein p400)
Epc1  (enhancer of polycomb homolog 1)
Epc2  (enhancer of polycomb homolog 2)
Ing3  (inhibitor of growth family, member 3)
Ino80  (INO80 complex ATPase subunit)
Ino80b  (INO80 complex subunit B)
Ino80c  (INO80 complex subunit C)
Ino80d  (INO80 complex subunit D)
Ino80e  (INO80 complex subunit E)
Kat5  (lysine acetyltransferase 5)
Mcrs1  (microspherule protein 1)
Meaf6  (MYST/Esa1-associated factor 6)
Morf4l2  (mortality factor 4 like 2)
Nfrkb  (nuclear factor related to kappa B binding protein)
Ruvbl1  (RuvB-like AAA ATPase 1)
Ruvbl2  (RuvB-like AAA ATPase 2)
Srcap  (Snf2-related CREBBP activator protein)
Tfpt  (TCF3 fusion partner)
Trrap  (transformation/transcription domain-associated protein)
Uchl5  (ubiquitin C-terminal hydrolase L5)
Vps72  (vacuolar protein sorting 72 homolog)
Yeats4  (YEATS domain containing 4)
Yy1  (YY1 transcription factor)
Znhit1  (zinc finger, HIT-type containing 1)

Genes (Mus musculus)
Actb  (actin, beta)
Actl6a  (actin-like 6A)
Actr5  (ARP5 actin-related protein 5)
Actr6  (ARP6 actin-related protein 6)
Actr8  (ARP8 actin-related protein 8)
Brd8  (bromodomain containing 8)
Dmap1  (DNA methyltransferase 1-associated protein 1)
Ep400  (E1A binding protein p400)
Epc1  (enhancer of polycomb homolog 1)
Epc2  (enhancer of polycomb homolog 2)
Ing3  (inhibitor of growth family, member 3)
Ino80  (INO80 complex subunit)
Ino80b  (INO80 complex subunit B)
Ino80c  (INO80 complex subunit C)
Ino80d  (INO80 complex subunit D)
Ino80e  (INO80 complex subunit E)
Kat5  (K(lysine) acetyltransferase 5)
Mcrs1  (microspherule protein 1)
Meaf6  (MYST/Esa1-associated factor 6)
Morf4l1  (mortality factor 4 like 1)
Morf4l2  (mortality factor 4 like 2)
Mrgbp  (MRG/MORF4L binding protein)
Nfrkb  (nuclear factor related to kappa B binding protein)
Ruvbl1  (RuvB-like AAA ATPase 1)
Ruvbl2  (RuvB-like AAA ATPase 2)
Srcap  (Snf2-related CREBBP activator protein)
Tfpt  (TCF3 (E2A) fusion partner)
Trrap  (transformation/transcription domain-associated protein)
Uchl5  (ubiquitin carboxyl-terminal esterase L5)
Vps72  (vacuolar protein sorting 72)
Yeats4  (YEATS domain containing 4)
Yy1  (YY1 transcription factor)
Znhit1  (zinc finger, HIT domain containing 1)

Genes (Homo sapiens)
ACTB  (actin beta)
ACTL6A  (actin like 6A)
ACTR5  (actin related protein 5)
ACTR6  (actin related protein 6)
ACTR8  (actin related protein 8)
BRD8  (bromodomain containing 8)
DMAP1  (DNA methyltransferase 1 associated protein 1)
EP400  (E1A binding protein p400)
EPC1  (enhancer of polycomb homolog 1)
EPC2  (enhancer of polycomb homolog 2)
ING3  (inhibitor of growth family member 3)
INO80  (INO80 complex ATPase subunit)
INO80B  (INO80 complex subunit B)
INO80C  (INO80 complex subunit C)
INO80D  (INO80 complex subunit D)
INO80E  (INO80 complex subunit E)
KAT5  (lysine acetyltransferase 5)
MCRS1  (microspherule protein 1)
MEAF6  (MYST/Esa1 associated factor 6)
MORF4L1  (mortality factor 4 like 1)
MORF4L2  (mortality factor 4 like 2)
MRGBP  (MRG domain binding protein)
NFRKB  (nuclear factor related to kappaB binding protein)
RUVBL1  (RuvB like AAA ATPase 1)
RUVBL2  (RuvB like AAA ATPase 2)
SRCAP  (Snf2 related CREBBP activator protein)
TFPT  (TCF3 fusion partner)
TRRAP  (transformation/transcription domain associated protein)
UCHL5  (ubiquitin C-terminal hydrolase L5)
VPS72  (vacuolar protein sorting 72 homolog)
YEATS4  (YEATS domain containing 4)
YY1  (YY1 transcription factor)
ZNHIT1  (zinc finger HIT-type containing 1)


Additional Information