F3 (coagulation factor III, tissue factor) - Rat Genome Database

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Gene: F3 (coagulation factor III, tissue factor) Canis lupus familiaris
Analyze
Symbol: F3
Name: coagulation factor III, tissue factor
RGD ID: 12133906
Description: ENCODES a protein that exhibits phospholipid binding (ortholog); protease binding (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN activation of plasma proteins involved in acute inflammatory response (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cell surface (ortholog); extracellular matrix (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TF; tissue factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,709,581 - 54,720,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,708,471 - 54,720,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,083,526 - 55,096,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct disease  (ISO)
Breast Neoplasms  (ISO)
Cardiac Allograft Vasculopathy  (ISO)
Cardiac Fibrosis  (ISO)
carotid artery thrombosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
COVID-19  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
Hemorrhage  (ISO)
hypertension  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Metabolic Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neointima  (ISO)
nephrotic syndrome  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovary Reperfusion Injury  (ISO)
Peritoneal Fibrosis  (ISO)
pre-eclampsia  (ISO)
preterm premature rupture of the membranes  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Snake Bites  (ISO)
Spontaneous Abortions  (ISO)
Spontaneous Coronary Artery Dissection  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thrombosis  (ISO)
Viral Myocarditis  (ISO)
von Willebrand's disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:20524980   PMID:21801068   PMID:22301074   PMID:24674618  


Genomics

Comparative Map Data
F3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,709,581 - 54,720,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,708,471 - 54,720,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,083,526 - 55,096,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBIUU_Cfam_GSD_1.0
F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,529,173 - 94,541,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,529,173 - 94,541,759 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,994,729 - 95,007,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
T2T-CHM13v2.0194,377,216 - 94,389,797 (-)NCBIT2T-CHM13v2.0
F3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,517,186 - 121,528,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,517,186 - 121,528,697 (+)EnsemblGRCm39 Ensembl
GRCm383121,723,537 - 121,735,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,723,537 - 121,735,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,426,455 - 121,437,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363121,715,560 - 121,727,066 (+)NCBIMGSCv36mm8
Celera3128,097,400 - 128,112,071 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
F3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,511,675 - 212,523,375 (+)NCBIGRCr8
mRatBN7.22209,827,061 - 209,838,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,826,959 - 209,838,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2217,490,132 - 217,501,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,397,871 - 215,409,409 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,239,702 - 210,251,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Celera2202,257,415 - 202,269,039 (+)NCBICelera
Cytogenetic Map2q42NCBI
F3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423254,189 - 264,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423254,060 - 264,448 (+)NCBIChiLan1.0ChiLan1.0
F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21132,482,788 - 132,495,423 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11131,637,687 - 131,650,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,190,381 - 97,203,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,918,359 - 95,931,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,918,502 - 95,931,050 (-)Ensemblpanpan1.1panPan2
F3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,300,058 - 104,310,937 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,636,667 - 4,647,916 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,637,028 - 4,647,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,826,644 - 122,837,666 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,827,018 - 122,837,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,474,466 - 134,479,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,726,690 - 38,738,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,726,798 - 38,739,408 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603379,312,870 - 79,325,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,112,801 - 3,124,301 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F3
181 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 10 3 6 11 10 6
Low 1 12 6 3 6 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000032008   ⟹   ENSCAFP00000029806
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl654,709,608 - 54,720,607 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064889   ⟹   ENSCAFP00000063299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl654,708,471 - 54,720,593 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080035   ⟹   ENSCAFP00000047580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl654,710,203 - 54,720,593 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092331   ⟹   ENSCAFP00000046296
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl654,709,608 - 54,719,733 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026385   ⟹   ENSCAFP00845020798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl655,083,526 - 55,096,250 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026421   ⟹   ENSCAFP00845020823
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl655,085,260 - 55,096,264 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026446   ⟹   ENSCAFP00845020841
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl655,085,260 - 55,096,264 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026470   ⟹   ENSCAFP00845020862
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl655,085,855 - 55,096,250 (+)Ensembl
RefSeq Acc Id: NM_001024640   ⟹   NP_001019811
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1654,709,656 - 54,720,593 (+)NCBI
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBI
ROS_Cfam_1.0655,085,308 - 55,096,250 (+)NCBI
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBI
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBI
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038667616   ⟹   XP_038523544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001019811   ⟸   NM_001024640
- Peptide Label: precursor
- UniProtKB: Q4W6L5 (UniProtKB/TrEMBL),   A0A8C0KG26 (UniProtKB/TrEMBL),   A0A8C0NAL8 (UniProtKB/TrEMBL),   F1P845 (UniProtKB/TrEMBL),   A0A8C0RWZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000063299   ⟸   ENSCAFT00000064889
RefSeq Acc Id: ENSCAFP00000047580   ⟸   ENSCAFT00000080035
RefSeq Acc Id: ENSCAFP00000046296   ⟸   ENSCAFT00000092331
RefSeq Acc Id: ENSCAFP00000029806   ⟸   ENSCAFT00000032008
RefSeq Acc Id: XP_038523544   ⟸   XM_038667616
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NUU2 (UniProtKB/TrEMBL),   A0A8P0NL96 (UniProtKB/TrEMBL),   A0A8C0RWZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020862   ⟸   ENSCAFT00845026470
RefSeq Acc Id: ENSCAFP00845020823   ⟸   ENSCAFT00845026421
RefSeq Acc Id: ENSCAFP00845020841   ⟸   ENSCAFT00845026446
RefSeq Acc Id: ENSCAFP00845020798   ⟸   ENSCAFT00845026385
Protein Domains
Fibronectin type-III   Interferon/interleukin receptor

Promoters
RGD ID:13683808
Promoter ID:EPDNEW_C1877
Type:multiple initiation site
Name:F3_1
Description:coagulation factor III, tissue factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1654,709,601 - 54,709,661EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020110 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013358 UniProtKB/TrEMBL
  ENSCAFG00040003572 UniProtKB/TrEMBL
  ENSCAFG00845014757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000032008.5 UniProtKB/TrEMBL
  ENSCAFT00000064889.2 UniProtKB/TrEMBL
  ENSCAFT00000080035.2 UniProtKB/TrEMBL
  ENSCAFT00000092331.2 UniProtKB/TrEMBL
  ENSCAFT00030024803.1 UniProtKB/TrEMBL
  ENSCAFT00030024857.1 UniProtKB/TrEMBL
  ENSCAFT00030024913.1 UniProtKB/TrEMBL
  ENSCAFT00040006801.1 UniProtKB/TrEMBL
  ENSCAFT00040006813.1 UniProtKB/TrEMBL
  ENSCAFT00040006847.1 UniProtKB/TrEMBL
  ENSCAFT00040006866.1 UniProtKB/TrEMBL
  ENSCAFT00845026385.1 UniProtKB/TrEMBL
  ENSCAFT00845026421.1 UniProtKB/TrEMBL
  ENSCAFT00845026446 ENTREZGENE
  ENSCAFT00845026446.1 UniProtKB/TrEMBL
  ENSCAFT00845026470 ENTREZGENE
  ENSCAFT00845026470.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Interferon/interleukin_rcp_dom UniProtKB/TrEMBL
  Tissue_factor UniProtKB/TrEMBL
  Tissue_Factor_CS UniProtKB/TrEMBL
KEGG Report cfa:490153 UniProtKB/TrEMBL
NCBI Gene F3 ENTREZGENE
PANTHER INTERFERON/INTERLEUKIN RECEPTOR UniProtKB/TrEMBL
  PTHR20859:SF22 UniProtKB/TrEMBL
Pfam Interfer-bind UniProtKB/TrEMBL
  Tissue_fac UniProtKB/TrEMBL
PIRSF Tissue_factor_3 UniProtKB/TrEMBL
PRINTS TISSUEFACTOR UniProtKB/TrEMBL
PROSITE TISSUE_FACTOR UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt A0A8C0KG26 ENTREZGENE
  A0A8C0N594_CANLF UniProtKB/TrEMBL
  A0A8C0NAL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q3D3_CANLF UniProtKB/TrEMBL
  A0A8C0Q6L8_CANLF UniProtKB/TrEMBL
  A0A8C0QAQ0_CANLF UniProtKB/TrEMBL
  A0A8C0RJE6_CANLF UniProtKB/TrEMBL
  A0A8C0RWZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NKS3_CANLF UniProtKB/TrEMBL
  A0A8I3NRR4_CANLF UniProtKB/TrEMBL
  A0A8I3NRT3_CANLF UniProtKB/TrEMBL
  A0A8I3NUU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NL96 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PC28_CANLF UniProtKB/TrEMBL
  A0A8P0SZ98_CANLF UniProtKB/TrEMBL
  F1P845 ENTREZGENE
  Q4W6L5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1P845 UniProtKB/TrEMBL
VGNC ID VGNC:54021 ENTREZGENE