PPARA (peroxisome proliferator activated receptor alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PPARA (peroxisome proliferator activated receptor alpha) Pan paniscus
Analyze
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
RGD ID: 11757610
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBINHGRI_mPanPan1
PanPan1.12245,218,364 - 45,302,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (ISO)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
hydrocephalus  (ISO)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (ISO)
hypertensive encephalopathy  (ISO)
Hypertensive Nephropathy  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
periodontitis  (ISO)
Phelan-McDermid syndrome  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
steatotic liver disease  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (ISO)
cell communication  (IEA)
cell differentiation  (IEA)
cellular response to fructose stimulus  (ISO)
cellular response to starvation  (IEA)
circadian regulation of gene expression  (IEA)
enamel mineralization  (IEA,ISO)
epidermis development  (IEA,ISO)
fatty acid metabolic process  (IEA,ISO)
gluconeogenesis  (IEA,ISO)
heart development  (ISO)
hormone-mediated signaling pathway  (IEA)
intracellular receptor signaling pathway  (IEA)
lipoprotein metabolic process  (ISO)
negative regulation of appetite  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cholesterol storage  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of glycolytic process  (IEA)
negative regulation of hepatocyte apoptotic process  (IEA,ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of leukocyte cell-cell adhesion  (IEA)
negative regulation of macrophage derived foam cell differentiation  (IEA)
negative regulation of miRNA transcription  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of protein binding  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
negative regulation of sequestering of triglyceride  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
nitric oxide metabolic process  (ISO)
positive regulation of ATP biosynthetic process  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fatty acid metabolic process  (IEA)
positive regulation of fatty acid oxidation  (IEA)
positive regulation of gluconeogenesis  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of cellular ketone metabolic process  (IEA)
regulation of circadian rhythm  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fatty acid metabolic process  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of lipid storage  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
steroid hormone mediated signaling pathway  (IEA)
wound healing  (IEA,ISO)

Cellular Component
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBINHGRI_mPanPan1
PanPan1.12245,218,364 - 45,302,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensemblpanpan1.1panPan2
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,150,521 - 46,243,755 (+)EnsemblGRCh38hg38GRCh38
GRCh372246,546,429 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBICelera
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
T2T-CHM13v2.02246,635,225 - 46,728,457 (+)NCBIT2T-CHM13v2.0
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,619,184 - 85,687,020 (+)EnsemblGRCm39 Ensembl
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBIMGSCv36mm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,862,969 - 19,928,467 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,667,818 - 20,740,885 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,668,580 - 20,740,947 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,394,544 - 20,460,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,707,323 - 20,772,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,889,156 - 20,954,630 (-)NCBIUU_Cfam_GSD_1.0
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,665,412 - 3,725,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,672,460 - 3,725,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,741 - 3,364,239 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223491
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,614,892 - 28,709,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppara
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000056285   ⟹   ENSPPAP00000033410
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensembl
RefSeq Acc Id: XM_008964792   ⟹   XP_008963040
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22355,981,408 - 56,072,797 (+)NCBI
NHGRI_mPanPan12258,679,404 - 58,770,754 (+)NCBI
PanPan1.12245,218,364 - 45,302,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024927111   ⟹   XP_024782879
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22355,981,408 - 56,072,797 (+)NCBI
NHGRI_mPanPan12258,679,404 - 58,770,754 (+)NCBI
PanPan1.12245,218,364 - 45,302,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034951723   ⟹   XP_034807614
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBI
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBI
RefSeq Acc Id: XM_034951724   ⟹   XP_034807615
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBI
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBI
RefSeq Acc Id: XM_063603151   ⟹   XP_063459221
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22356,022,680 - 56,072,797 (+)NCBI
RefSeq Acc Id: XM_063603152   ⟹   XP_063459222
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22355,981,408 - 56,072,797 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008963040   ⟸   XM_008964792
- UniProtKB: A0A2R9BY52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024782879   ⟸   XM_024927111
- UniProtKB: A0A2R9BY52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000033410   ⟸   ENSPPAT00000056285
RefSeq Acc Id: XP_034807614   ⟸   XM_034951723
- UniProtKB: A0A2R9BY52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034807615   ⟸   XM_034951724
- UniProtKB: A0A2R9BY52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459222   ⟸   XM_063603152
- UniProtKB: A0A2R9BY52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459221   ⟸   XM_063603151
- UniProtKB: A0A2R9BY52 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039570 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056285.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  PPAR-alpha UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report pps:100975411 UniProtKB/TrEMBL
NCBI Gene PPARA ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS PROXISOMEPAR UniProtKB/TrEMBL
  PROXISOMPAAR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A2R9BY52 ENTREZGENE, UniProtKB/TrEMBL