RGD Reference Report - WY-14643, a Potent Peroxisome Proliferator Activator Receptor-alpha PPAR-alpha Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. - Rat Genome Database

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WY-14643, a Potent Peroxisome Proliferator Activator Receptor-alpha PPAR-alpha Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis.

Authors: Briguglio, E  Di Paola, R  Paterniti, I  Mazzon, E  Oteri, G  Cordasco, G  Cuzzocrea, S 
Citation: Briguglio E, etal., PPAR Res. 2010;2010:193019. Epub 2010 Dec 27.
RGD ID: 5509938
Pubmed: PMID:21253492   (View Abstract at PubMed)
PMCID: PMC3022213   (View Article at PubMed Central)
DOI: DOI:10.1155/2010/193019   (Journal Full-text)

We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-alpha (PPAR-alpha) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received WY14643 (1 mg/kg i.p, daily for eight days). Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF-kappaB expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of WY14643 significantly decreased all of the parameters of inflammation as described above. These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
periodontitis  ISOPpara (Rattus norvegicus)5509938; 5509938possible therapeutic targetRGD 
periodontitis  IDA 5509938possible therapeutic targetRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppara  (peroxisome proliferator activated receptor alpha)

Genes (Mus musculus)
Ppara  (peroxisome proliferator activated receptor alpha)

Genes (Homo sapiens)
PPARA  (peroxisome proliferator activated receptor alpha)


Additional Information