Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 2123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apc
Name: APC regulator of WNT signaling pathway
Acc ID: DOID:684
Term: hepatocellular carcinoma
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma "DO" "DO", http://en.wikipedia.org/wiki/Hepatocellular_carcinoma "DO" "DO", http://www.omim.org/entry/114550 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apc ISOAPC (Homo sapiens)14402050RGDDNA:hypermethylation 
Apc ISOAPC (Homo sapiens)7240710OMIM  
Apc ISOAPC (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Apc ISOAPC (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinomaPMID:11247896 PMID:11466687 PMID:1316610 PMID:15311282 PMID:15459959 PMID:17293347 PMID:17489848 PMID:17576681 PMID:18199528 PMID:19793053 PMID:20223039 PMID:20685668 PMID:21859464 PMID:21901162 PMID:22135120 PMID:22425061 PMID:22431159 PMID:22447671 PMID:22703879 PMID:23159591 PMID:23460355 PMID:23484150 PMID:24033266 PMID:24448499 PMID:24573554 PMID:24599579 PMID:24728327 PMID:25186627 PMID:25479140 PMID:25590978 PMID:25637381 PMID:25741868 PMID:25925381 PMID:25980754 PMID:26207792 PMID:26447891 PMID:26467025 PMID:26530882 PMID:26580448 PMID:26690363 PMID:26845104 PMID:26900293 PMID:27028212 PMID:27081525 PMID:27150160 PMID:27600092 PMID:28051113 PMID:28127413 PMID:28135048 PMID:28135145 PMID:28195569 PMID:28492532 PMID:29641532 PMID:29684080 PMID:30267214 PMID:30374176 PMID:31428572 PMID:32390703 PMID:34426522 PMID:35189564 PMID:35264596 PMID:8381579 PMID:8381580 PMID:9536098 PMID:9824584
Apc ISOAPC (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinomaPMID:11466687 PMID:1316610 PMID:15311282 PMID:17293347 PMID:22135120 PMID:24728327 PMID:25479140 PMID:25741868 PMID:26530882 PMID:27081525 PMID:28135048 PMID:28195569 PMID:28492532 PMID:8381579 PMID:9824584
Apc ISSApc (Mus musculus)13592920MouseDOOMIM:114550 
Go Back to source page   Continue to Ontology report