PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: cortisol biosynthetic pathway
Accession: PW:0000774
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Definition: Those metabolic reactions involved in the synthesis of cortisol, a C21 glucocorticoid produced in the middle zone, the zona fasciculata, of the adrenal cortex from cholesterol as the precursor. It plays important roles in the metabolism of carbohydrates and other nutrients.
Synonyms: related_synonym: cortisol biosynthetic process
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
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Fdx1
ferredoxin 1
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
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Fdxr
ferredoxin reductase
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ISO
RGD
PMID:15583024
RGD:4889549
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Por
cytochrome p450 oxidoreductase
ISO
RGD
PMID:17926129
RGD:4892309
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Star
steroidogenic acute regulatory protein
ISO
RGD
PMID:18821018
RGD:2325883
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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