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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 11-deoxycorticosterone | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Desoxycorticosterone | CTD | PMID:16054388 | 11-deoxycorticosterone | increases chemical synthesis | ISO | RGD:70835 | 6480464 | CYP11B1 protein results in increased chemical synthesis of Desoxycorticosterone | CTD | PMID:19900470 | 11-deoxycorticosterone | multiple interactions | EXP | | 6480464 | Plant Extracts inhibits the reaction [Desoxycorticosterone binds to CYP11B1 protein] | CTD | PMID:15666820 | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:16030167 more ... | 11-deoxycortisol | increases metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein results in increased metabolism of Cortodoxone | CTD | PMID:19900470 | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:15522937 more ... | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:15780661 more ... | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:16030167 more ... | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:16030167 more ... | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:16030167 more ... | 11-deoxycortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Cortodoxone | CTD | PMID:15780661 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP11B1 mRNA | CTD | PMID:16254025 | 3',5'-cyclic AMP | increases expression | ISO | RGD:70835 | 6480464 | Cyclic AMP results in increased expression of CYP11B1 mRNA | CTD | PMID:22172629 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:70835 | 6480464 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of CYP11B1 mRNA] | CTD | PMID:22172629 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:70835 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA | CTD | PMID:16396990 more ... | 3,3',4,4',5-pentachlorobiphenyl | multiple interactions | ISO | RGD:70835 | 6480464 | 3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA] | CTD | PMID:16396990 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:70835 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA | CTD | PMID:16216300 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases activity | ISO | RGD:70835 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP11B1 protein | CTD | PMID:15703266 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:70835 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA | CTD | PMID:15703266 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:70835 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA | CTD | PMID:15703266 more ... | 3,3',4,4'-tetrachlorobiphenyl | increases expression | ISO | RGD:70835 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP11B1 mRNA | CTD | PMID:16396990 | 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol | decreases expression | ISO | RGD:70835 | 6480464 | 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B1 mRNA; more ... | CTD | PMID:20615422 | 8-bromo-3',5'-cyclic AMP | multiple interactions | ISO | RGD:70835 | 6480464 | Mitotane affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA] | CTD | PMID:22546480 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:70835 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA | CTD | PMID:22079614 more ... | apigenin | decreases expression | ISO | RGD:70835 | 6480464 | Apigenin results in decreased expression of CYP11B1 mRNA | CTD | PMID:22172629 | cis-ketoconazole | decreases activity | ISO | RGD:70835 | 6480464 | Ketoconazole results in decreased activity of CYP11B1 protein | CTD | PMID:15743198 | corticosterone | increases chemical synthesis | ISO | RGD:70835 | 6480464 | CYP11B1 protein results in increased chemical synthesis of Corticosterone | CTD | PMID:16054388 | cortisol | affects metabolic processing | ISO | RGD:70835 | 6480464 | CYP11B1 protein affects the metabolism of Hydrocortisone | CTD | PMID:16030167 | cortisol | multiple interactions | ISO | RGD:70835 | 6480464 | 3',4'-dimethoxyflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]; more ... | CTD | PMID:22172629 | cortisol | increases chemical synthesis | ISO | RGD:70835 | 6480464 | CYP11B1 protein results in increased chemical synthesis of Hydrocortisone | CTD | PMID:16054388 PMID:19900470 | cortisol | increases chemical synthesis | ISO | RGD:70835 | 6480464 | CYP11B1 protein results in increased chemical synthesis of Hydrocortisone | CTD | PMID:16054388 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of CYP11B1 mRNA | CTD | PMID:21266533 | diheptyl phthalate | decreases expression | EXP | | 6480464 | diheptyl phthalate results in decreased expression of CYP11B1 mRNA | CTD | PMID:22112501 | diisononyl phthalate | decreases expression | EXP | | 6480464 | diisononyl phthalate results in decreased expression of CYP11B1 mRNA | CTD | PMID:22112501 | dipentyl phthalate | decreases expression | EXP | | 6480464 | di-n-pentyl phthalate results in decreased expression of CYP11B1 mRNA | CTD | PMID:22112501 | etomidate | decreases activity | ISO | RGD:10428 | 6480464 | Etomidate results in decreased activity of CYP11B1 protein | CTD | PMID:18651133 | etomidate | multiple interactions | ISO | RGD:10428 | 6480464 | Etomidate inhibits the reaction [Forskolin results in increased activity of CYP11B1 protein] | CTD | PMID:18651133 | gamma-hexachlorocyclohexane | multiple interactions | ISO | RGD:70835 | 6480464 | Lindane inhibits the reaction [Forskolin results in increased expression of CYP11B1 mRNA] | CTD | PMID:17080404 | potassium chloride | multiple interactions | ISO | RGD:70835 | 6480464 | benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA] | CTD | PMID:18331727 | potassium chloride | increases expression | ISO | RGD:70835 | 6480464 | Potassium Chloride results in increased expression of CYP11B1 mRNA | CTD | PMID:18331727 | quercetin | decreases expression | ISO | RGD:70835 | 6480464 | Quercetin results in decreased expression of CYP11B1 mRNA | CTD | PMID:22172629 | testosterone | decreases expression | EXP | | 6480464 | Testosterone results in decreased expression of CYP11B1 mRNA; more ... | CTD | PMID:1655649 | testosterone | decreases activity | EXP | | 6480464 | Testosterone results in decreased activity of CYP11B1 protein | CTD | PMID:1655649 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of CYP11B1 mRNA | CTD | PMID:18653662 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Steroid hormone biosynthesis | |
Disease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Steroid hormone biosynthesis | |
References - curated| 1. |
Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18. |
| 2. |
Chen YC, etal., FEBS Lett. 2010 Nov 5;584(21):4442-8. Epub 2010 Oct 13. |
| 3. |
Cicila GT, etal., Nat Genet 1993 Apr;3(4):346-53. |
| 4. |
Demberg T, etal., Scand J Immunol 2002 Aug;56(2):149-60. |
| 5. |
Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16. |
| 8. |
Helmberg A, etal., J Clin Endocrinol Metab 1992 Nov;75(5):1278-81. |
| 9. |
Huang XJ, etal., Toxicol Lett. 2009 Dec 15;191(2-3):167-73. Epub 2009 Sep 4. |
| 10. |
KEGG |
| 11. |
Lifton RP, etal., Nature. 1992 Jan 16;355(6357):262-5. |
| 12. |
Lo MJ and Lee SD, Immunol Cell Biol. 2006 Feb;84(1):38-43. |
| 13. |
Matsukawa N, etal., Biochem Biophys Res Commun 1990 May 31;169(1):245-52. |
| 14. |
Matsukawa N, etal., J Biol Chem 1993 Apr 25;268(12):9117-21. |
| 15. |
Mutoh J, etal., Endocrinology. 2006 Feb;147(2):927-36. Epub 2005 Oct 27. |
| 16. |
Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34. |
| 17. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 18. |
Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7. |
| 19. |
Ohtani T, etal., J Hypertens. 2009 May;27(5):1074-83. |
| 20. |
Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70. |
| 21. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 22. |
RGD automated data pipeline |
| 23. |
RGD automated import pipeline for gene-chemical interactions |
| 24. |
RGD Automated Pipelines |
| 25. |
Skinner CA, etal., J Clin Endocrinol Metab. 1996 Jun;81(6):2389-93. |
| 26. |
Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2. |
| 27. |
Wang GM, etal., Endocrinology 2002 Feb;143(2):621-6. |
| 28. |
Ye P, etal., Endocrinology. 2005 Dec;146(12):5287-93. Epub 2005 Sep 22. |
| 29. |
Ye P, etal., J Endocrinol. 2008 Feb;196(2):305-11. |
References - uncuratedRGD Disease Portals| Cyp11b1 has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Cyp11b1 (Rattus norvegicus) |
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| CYP11B1 (Homo sapiens) |
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| Cyp11b1 (Mus musculus) |
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Position Markers| D7Wox19 |
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| D7Wox16 |
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| D7Wox18 |
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| D7Mco7 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat Strains
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Nucleotide Sequences| Nucleotide RefSeqs | NM_012537 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | CH473950 | (Get FASTA) | Search GEO for Microarray Profiles |
| D10107 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D11354 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X15431 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012537 | ||||||||||
| RefSeq Status: | VALIDATED | ||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | NP_036669 | ||||||||||
| Peptide Label: | precursor | ||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036669 | (Get FASTA) |
| GenBank Protein | BAA00988 | (Get FASTA) |
| BAA01957 | (Get FASTA) | |
| CAA33472 | (Get FASTA) | |
| EDM16081 | (Get FASTA) | |
| P15393 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Entrez Gene | 500892 | ENTREZGENE |
| Gene3D-CATH | Cyt_P450 | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000032450 | UniProtKB/Swiss-Prot |
| InterPro | Cyt_P450 | UniProtKB/Swiss-Prot |
| Cyt_P450_CS | UniProtKB/Swiss-Prot | |
| Cyt_P450_mit_N | UniProtKB/Swiss-Prot | |
| IPI | IPI00734638 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:500892 | ENTREZGENE |
| Pfam | p450 | UniProtKB/Swiss-Prot |
| PRINTS | MITP450 | UniProtKB/Swiss-Prot |
| P450 | UniProtKB/Swiss-Prot | |
| PROSITE | CYTOCHROME_P450 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Cytochrome_P450 | UniProtKB/Swiss-Prot |
| UniGene | Rn.198235 | ENTREZGENE |
| UniProt | C11B1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-04-19 | Cyp11b1 | cytochrome P450, family 11, subfamily b, polypeptide 1 | Cyp11b1 | cytochrome P450, subfamily 11B, polypeptide 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-11-06 | Cyp11b1 | cytochrome P450, subfamily 11B, polypeptide 1 | Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase) | Name updated | 2225 | APPROVED | |
| 2002-06-10 | Cyp11b1 | Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase) | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | upregulated in Cushings syndrome | 70385 |
| gene_disease | candidate gene for a QTL affecting blood pressure (Bp61) | 69709 |
| gene_expression | expressed in leydig cells | 70385 |
| gene_function | catalyzes 11-beta-hydroxylation of steroids to produce 11-beta-OH-steroid derivatives | 70385 |
| gene_mutations_overexpression | mutant allele that may play a role in salt hypertension resistance is found in Dahl salt resistant strain SR/Jr | 69709 |
| gene_mutations_overexpression | mutant allele found in SR/Jr rat encodes five amino acid substitutions and is associated with reduced synthesis of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) | 69709 |
| gene_process | functions in glucocorticoid biosynthesis | 70385 |
| More on Cyp11b1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2453 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.