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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:C21-steroid hormone biosynthetic pathway
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Accession:PW:0000070 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of C21-steroid hormones. Pregnenolone, the first C21 steroid derived from cholesterol, and progesterone, to which pregnenolone can be converted, provide the starting materials for the biosynthesis of C21, C19 and C18 steroid hormones. The C21 class includes glucocorticoids such as cortisol and mineralocorticoids such as aldosterone. Glucocorticoids and mineralocorticoids are collectively referred to as corticosteroids.
Synonyms:related_synonym: C21-steroid hormone biosynthetic process;   corticosteroid biosynthetic pathway


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C21-steroid hormone biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 ISO RGD PMID:11832364 RGD:727991 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 ISS RGD PMID:11832364 RGD:727991 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
aldosterone biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 TAS RGD PMID:17926129 RGD:4892309 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 TAS RGD PMID:15583024 RGD:4889549 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 ISO RGD PMID:15583024 RGD:4889549 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
G CYP21A2 cytochrome P450 family 21 subfamily A member 2 ISO RGD PMID:15583024 RGD:4889549 NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644 		JBrowse link
G FDX1 ferredoxin 1 TAS RGD PMID:18821018 RGD:2325883 NCBI chr11:110,429,331...110,464,884
Ensembl chr11:110,429,948...110,464,884 		JBrowse link
G FDXR ferredoxin reductase TAS RGD PMID:18821018 RGD:2325883 NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031 		JBrowse link
G POR cytochrome p450 oxidoreductase TAS RGD PMID:17926129 RGD:4892309 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G STAR steroidogenic acute regulatory protein TAS RGD PMID:18821018 RGD:2325883 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
cortisol biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 TAS RGD PMID:17926129 RGD:4892309 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 TAS RGD PMID:15583024 RGD:4889549 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 TAS RGD PMID:17926129 RGD:4892309 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP21A2 cytochrome P450 family 21 subfamily A member 2 ISO RGD PMID:15583024 RGD:4889549 NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644 		JBrowse link
G FDX1 ferredoxin 1 TAS RGD PMID:18821018 RGD:2325883 NCBI chr11:110,429,331...110,464,884
Ensembl chr11:110,429,948...110,464,884 		JBrowse link
G FDXR ferredoxin reductase TAS RGD PMID:18821018 RGD:2325883 NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 TAS RGD PMID:15583024 RGD:4889549 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 TAS RGD PMID:15583024 RGD:4889549 NCBI chr 1:119,414,931...119,423,034
Ensembl chr 1:119,414,931...119,423,035 		JBrowse link
G POR cytochrome p450 oxidoreductase TAS RGD PMID:17926129 RGD:4892309 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G STAR steroidogenic acute regulatory protein TAS RGD PMID:18821018 RGD:2325883 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    classic metabolic pathway 1803
      lipid metabolic pathway 431
        isoprenoid metabolic pathway 96
          isoprenoid biosynthetic pathway 84
            steroid biosynthetic pathway 84
              steroid hormone biosynthetic pathway 61
                C21-steroid hormone biosynthetic pathway 11
                  glucocorticoid biosynthetic pathway + 10
                  mineralocorticoid biosynthetic pathway + 8
paths to the root