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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:levobupivacaine phgarmacodynamics pathway
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Accession:PW:0002442 term browser browse the term
Definition:The pathway of levobupivacaine-target interaction and of the biochemical or physiological responses to drug. It is the S-enantiomer of bupivacaine compared to which, it has a longer duration of action and is associated with less vasodilation. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00397


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levobupivacaine phgarmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a ISO SMPDB SMP:00397 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide ISO SMPDB SMP:00397 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide ISO SMPDB SMP:00397 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide ISO SMPDB SMP:00397 NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383 		JBrowse link
G Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide ISO SMPDB SMP:00397 NCBI chr 1:172,051,075...172,085,991
Ensembl chr 1:172,051,080...172,085,981 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide ISO SMPDB SMP:00397 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide ISO SMPDB SMP:00397 NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768 		JBrowse link
G Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide ISO SMPDB SMP:00397 NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting, beta 4 polypeptide ISO SMPDB SMP:00397 NCBI chr  X:37,404,999...37,425,661
Ensembl chr  X:37,405,061...37,425,646 		JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit ISO SMPDB SMP:00397 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Cacna2d2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 ISO SMPDB SMP:00397 NCBI chr 9:107,276,948...107,406,545
Ensembl chr 9:107,276,811...107,406,542 		JBrowse link
G Cacnb1 calcium channel, voltage-dependent, beta 1 subunit ISO SMPDB SMP:00397 NCBI chr11:97,892,339...97,913,860
Ensembl chr11:97,892,334...97,913,860 		JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 ISO SMPDB SMP:00397 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00397 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939 		JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00397 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00397 NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO SMPDB SMP:00397 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO SMPDB SMP:00397 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin3a glutamate receptor ionotropic, NMDA3A ISO SMPDB SMP:00397 NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO SMPDB SMP:00397 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 ISO SMPDB SMP:00397 NCBI chr 6:21,212,101...21,729,804
Ensembl chr 6:21,215,502...21,729,804 		JBrowse link
G Kcnip2 Kv channel-interacting protein 2 ISO SMPDB SMP:00397 NCBI chr19:45,780,785...45,804,948
Ensembl chr19:45,780,278...45,804,500 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO SMPDB SMP:00397 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00397 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO SMPDB SMP:00397 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Scn10a sodium channel, voltage-gated, type X, alpha ISO SMPDB SMP:00397 NCBI chr 9:119,437,522...119,548,388
Ensembl chr 9:119,437,522...119,548,388 		JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta ISO SMPDB SMP:00397 NCBI chr 7:30,815,949...30,826,436
Ensembl chr 7:30,815,949...30,826,428 		JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 ISO SMPDB SMP:00397 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO SMPDB SMP:00397 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ISO SMPDB SMP:00397 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6070
    drug pathway 402
      nervous system drug pathway 190
        anesthetic drug pathway 80
          levobupivacaine drug pathway 30
            levobupivacaine phgarmacodynamics pathway 30
paths to the root