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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:quinidine pharmacodynamics pathway
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Accession:PW:0001851 term browser browse the term
Definition:The pathway of quinidine-target interaction and of the biochemical or physiological responses to drug. Its primary action is blocking the fast inward sodium current. However, it can impact on other currents and channels, such as the slow inward calcium, the rapid and slow components of the delayed potassium, and the inward potassium rectifier currents, and the ATP-sensitive potassium channel. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00323


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quinidine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 EXP SMPDB SMP:00323 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894 		JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 EXP SMPDB SMP:00323 NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543 		JBrowse link
G ADRB1 adrenoceptor beta 1 EXP SMPDB SMP:00323 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904 		JBrowse link
G AGTR1 angiotensin II receptor type 1 EXP SMPDB SMP:00323 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G ALG10B ALG10 alpha-1,2-glucosyltransferase B EXP SMPDB SMP:00323 NCBI chr12:38,316,687...38,329,721
Ensembl chr12:38,316,762...38,329,721 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 EXP SMPDB SMP:00323 NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 EXP SMPDB SMP:00323 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 EXP SMPDB SMP:00323 NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497 		JBrowse link
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 EXP SMPDB SMP:00323 NCBI chr 1:160,151,603...160,186,980
Ensembl chr 1:160,151,586...160,186,980 		JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 EXP SMPDB SMP:00323 NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992 		JBrowse link
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 EXP SMPDB SMP:00323 NCBI chr17:7,646,627...7,657,770
Ensembl chr17:7,646,627...7,657,770 		JBrowse link
G ATP1B3 ATPase Na+/K+ transporting subunit beta 3 EXP SMPDB SMP:00323 NCBI chr 3:141,876,643...141,926,549
Ensembl chr 3:141,876,124...141,926,549 		JBrowse link
G ATP1B4 ATPase Na+/K+ transporting family member beta 4 EXP SMPDB SMP:00323 NCBI chr  X:120,362,089...120,383,237
Ensembl chr  X:120,362,085...120,383,249 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 EXP SMPDB SMP:00323 NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C EXP SMPDB SMP:00323 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G EXP SMPDB SMP:00323 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H EXP SMPDB SMP:00323 NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169 		JBrowse link
G CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 EXP SMPDB SMP:00323 NCBI chr 3:50,362,613...50,504,244
Ensembl chr 3:50,362,613...50,504,244 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 EXP SMPDB SMP:00323 NCBI chr17:39,173,453...39,197,669
Ensembl chr17:39,173,453...39,197,702 		JBrowse link
G CALM1 calmodulin 1 EXP SMPDB SMP:00323 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 EXP SMPDB SMP:00323 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 EXP SMPDB SMP:00323 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330 		JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 EXP SMPDB SMP:00323 NCBI chr11:117,820,057...117,828,089
Ensembl chr11:117,800,844...117,828,698 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 EXP SMPDB SMP:00323 NCBI chr15:73,319,859...73,368,958
Ensembl chr15:73,319,859...73,368,958 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 EXP SMPDB SMP:00323 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 EXP SMPDB SMP:00323 NCBI chr12:5,043,879...5,046,788
Ensembl chr12:5,043,879...5,046,788 		JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 EXP SMPDB SMP:00323 NCBI chr 1:111,770,662...111,989,668
Ensembl chr 1:111,770,662...111,989,668 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 EXP SMPDB SMP:00323 NCBI chr21:34,446,688...34,512,210
Ensembl chr21:34,446,688...34,512,214 		JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 EXP SMPDB SMP:00323 NCBI chr21:34,364,006...34,371,381
Ensembl chr21:34,364,006...34,371,381 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 EXP SMPDB SMP:00323 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KCNIP2 potassium voltage-gated channel interacting protein 2 EXP SMPDB SMP:00323 NCBI chr10:101,825,974...101,843,800
Ensembl chr10:101,825,974...101,843,920 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 EXP SMPDB SMP:00323 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 EXP SMPDB SMP:00323 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044 		JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 EXP SMPDB SMP:00323 NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354 		JBrowse link
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 EXP SMPDB SMP:00323 NCBI chr22:38,426,327...38,455,199
Ensembl chr22:38,426,327...38,455,199 		JBrowse link
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 EXP SMPDB SMP:00323 NCBI chr11:128,891,356...128,921,163
Ensembl chr11:128,891,356...128,921,163 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 EXP SMPDB SMP:00323 NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600 		JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 EXP SMPDB SMP:00323 NCBI chr 1:233,614,106...233,672,514
Ensembl chr 1:233,614,106...233,672,514 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 EXP SMPDB SMP:00323 NCBI chr11:2,445,008...2,849,105
Ensembl chr11:2,444,654...2,849,105 		JBrowse link
G MYLK myosin light chain kinase EXP SMPDB SMP:00323 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332 		JBrowse link
G PLCB1 phospholipase C beta 1 EXP SMPDB SMP:00323 NCBI chr20:8,132,266...8,884,900
Ensembl chr20:8,077,251...8,968,360 		JBrowse link
G PLN phospholamban EXP SMPDB SMP:00323 NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha EXP SMPDB SMP:00323 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084 		JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha EXP SMPDB SMP:00323 NCBI chr17:68,413,623...68,551,316
Ensembl chr17:68,511,780...68,551,319 		JBrowse link
G RYR2 ryanodine receptor 2 EXP SMPDB SMP:00323 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 EXP SMPDB SMP:00323 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 EXP SMPDB SMP:00323 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053 		JBrowse link
G SNTA1 syntrophin alpha 1 EXP SMPDB SMP:00323 NCBI chr20:33,407,957...33,443,763
Ensembl chr20:33,407,957...33,443,763 		JBrowse link
G SNTB1 syntrophin beta 1 EXP SMPDB SMP:00323 NCBI chr 8:120,535,756...120,812,046
Ensembl chr 8:120,535,745...120,813,273 		JBrowse link
G SNTB2 syntrophin beta 2 EXP SMPDB SMP:00323 NCBI chr16:69,187,164...69,309,052
Ensembl chr16:69,187,147...69,309,052 		JBrowse link
G TNNC1 troponin C1, slow skeletal and cardiac type EXP SMPDB SMP:00323 NCBI chr 3:52,451,100...52,454,041
Ensembl chr 3:52,451,100...52,454,041 		JBrowse link
G TNNC2 troponin C2, fast skeletal type EXP SMPDB SMP:00323 NCBI chr20:45,823,214...45,833,306
Ensembl chr20:45,823,214...45,833,745 		JBrowse link
G TNNI1 troponin I1, slow skeletal type EXP SMPDB SMP:00323 NCBI chr 1:201,403,784...201,421,730
Ensembl chr 1:201,403,784...201,429,866 		JBrowse link
G TNNI2 troponin I2, fast skeletal type EXP SMPDB SMP:00323 NCBI chr11:1,838,981...1,841,678
Ensembl chr11:1,838,981...1,841,680 		JBrowse link
G TNNI3 troponin I3, cardiac type EXP SMPDB SMP:00323 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773 		JBrowse link
G TNNT1 troponin T1, slow skeletal type EXP SMPDB SMP:00323 NCBI chr19:55,132,698...55,149,206
Ensembl chr19:55,132,698...55,149,206 		JBrowse link
G TNNT2 troponin T2, cardiac type EXP SMPDB SMP:00323 NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764 		JBrowse link
G TNNT3 troponin T3, fast skeletal type EXP SMPDB SMP:00323 NCBI chr11:1,919,552...1,938,702
Ensembl chr11:1,919,703...1,938,706 		JBrowse link
G TPM1 tropomyosin 1 EXP SMPDB SMP:00323 NCBI chr15:63,042,747...63,071,915
Ensembl chr15:63,042,620...63,071,915 		JBrowse link
G TPM2 tropomyosin 2 EXP SMPDB SMP:00323 NCBI chr 9:35,681,993...35,690,056
Ensembl chr 9:35,681,992...35,690,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5956
    drug pathway 412
      cardiovascular system drug pathway 192
        antiarrhythmic drug pathway 100
          quinidine drug pathway 60
            quinidine pharmacodynamics pathway 60
paths to the root