Gene: KCNA5 (potassium voltage-gated channel subfamily A member 5) Homo sapiens
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Symbol: KCNA5
Name: potassium voltage-gated channel subfamily A member 5
Description: Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATFB7; cardiac potassium channel; HCK1; HK2; HPCN1; insulinoma and islet potassium channel; KV1.5; MGC117058; MGC117059; OTTHUMP00000238372; PCN1; potassium channel 1; potassium channel protein; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; voltage-gated potassium channel HK2; voltage-gated potassium channel protein Kv1.5; voltage-gated potassium channel subunit Kv1.5
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,043,919 - 5,046,788 (+)NCBIGRCh38hg38GRCh38
GRCh37125,153,085 - 5,155,954 (+)NCBIGRCh37hg19GRCh37
Build 36125,023,346 - 5,026,210 (+)NCBINCBI36hg18NCBI36
Build 34125,023,345 - 5,026,210NCBI
Celera126,774,165 - 6,777,029 (+)NCBI
Cytogenetic Map12p13.32NCBImapview
HuRef125,009,439 - 5,012,308 (+)NCBI
CHM1_1125,152,272 - 5,155,141 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
 
More on KCNA5
NCBI Gene
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RGD Object Information
RGD ID: 731065
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2017-09-12
Status: ACTIVE