Gene: HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4) Homo sapiens
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Symbol: HCN4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Description: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated k+ 4; OTTHUMP00000174871; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; SSS2
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381573,319,859 - 73,369,264 (-)NCBIGRCh38hg38GRCh38
GRCh371573,612,200 - 73,661,605 (-)NCBIGRCh37hg19GRCh37
Build 361571,400,988 - 71,448,230 (-)NCBINCBI36hg18NCBI36
Build 341571,400,987 - 71,448,230NCBI
Celera1550,490,801 - 50,540,207 (-)NCBI
Cytogenetic Map15q24.1NCBImapview
HuRef1550,443,643 - 50,492,812 (-)NCBI
CHM1_11573,730,167 - 73,779,572 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HCN4
NCBI Gene
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RGD Object Information
RGD ID: 737126
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2017-06-13
Status: ACTIVE