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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tamoxifen pharmacokinetics pathway
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Accession:PW:0000838 term browser browse the term
Definition:The pathway of processing - absorption, distribution, metabolism or elimination - of tamoxifen - a SERM anti-estrogen drug. Genetic variations can result in changes in the availability of the drug. For instance, variation in CYP2D6, an important enzyme for the production of a primary drug metabolite, impacts on the available concentration of the drug.
Synonyms:related_synonym: SMP:00606
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tamoxifen pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 IDA RGD PMID:21148080 RGD:5130188 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 IDA RGD PMID:12971802 RGD:5129544 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 IDA RGD PMID:12971802 RGD:5129544 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 IDA
EXP		 SMPDB
RGD		 PMID:12971802 SMP:00606, RGD:5129544 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 IDA RGD PMID:12971802 RGD:5129544 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 IDA RGD PMID:12971802 RGD:5129544 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 IDA RGD PMID:12971802 RGD:5129544 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 IDA
EXP		 SMPDB
RGD		 PMID:12971802 SMP:00606, RGD:5129544 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 IDA
EXP		 SMPDB
RGD		 PMID:12971802 SMP:00606, RGD:5129544 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 IDA
EXP		 SMPDB
RGD		 PMID:12971802 SMP:00606, RGD:5129544 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G ESR1 estrogen receptor 1 EXP SMPDB SMP:00606 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 EXP SMPDB SMP:00606 NCBI chr 1:171,248,494...171,285,978
Ensembl chr 1:171,248,471...171,285,978 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 EXP SMPDB SMP:00606 NCBI chr 1:171,090,905...171,117,819
Ensembl chr 1:171,090,901...171,117,819 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 TAS
EXP		 SMPDB
RGD		 PMID:19250197 SMP:00606, RGD:5129558 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 IDA
TAS		 RGD PMID:16099924 PMID:19250197 RGD:5129555, RGD:5129558 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 TAS RGD PMID:19250197 RGD:5129558 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 TAS
EXP		 SMPDB
RGD		 PMID:19250197 SMP:00606, RGD:5129558 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 TAS RGD PMID:19250197 RGD:5129558 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 TAS
EXP		 SMPDB
RGD		 PMID:19250197 SMP:00606, RGD:5129558 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 TAS RGD PMID:19250197 RGD:5129558 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 TAS RGD PMID:19250197 RGD:5129558 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 TAS RGD PMID:19250197 RGD:5129558 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 TAS RGD PMID:19250197 RGD:5129558 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5956
    drug pathway 412
      antineoplastic and immunomodulatory drug pathway 160
        antineoplastic drug pathway 159
          anti-estrogen drug pathway 29
            tamoxifen drug pathway 28
              tamoxifen pharmacokinetics pathway 23
paths to the root