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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:c-Jun N-terminal kinases MAPK signaling pathway
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Accession:PW:0000313 term browser browse the term
Definition:A stress-induced MAPK pathway that regulates an array of processes such as gene expression, cell migration, cytoskeletal organization and apoptosis.
Synonyms:related_synonym: JNK cascade;   JNK signaling pathway
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c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876, RGD:2293879 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:17208316 RGD:2293881 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:17208316 RGD:2293881 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:17208316 RGD:2293881 NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980 		JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO RGD PMID:11959862 RGD:2314491 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534 		JBrowse link
G Dusp8 dual specificity phosphatase 8 ISO RGD PMID:17208316 RGD:2293881 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO
IDA		 RGD PMID:17306896 PMID:17064355 PMID:10051439 RGD:2293875, RGD:2298577, RGD:2298561 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO
IDA		 RGD PMID:17306896 PMID:17064355 PMID:15680699 PMID:10051439 RGD:2293875, RGD:2298577, RGD:2298567, RGD:2298561 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 1:82,955,784...82,974,084
Ensembl chr 1:82,955,207...82,974,084 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO
IDA		 RGD PMID:8910292 PMID:17064355 PMID:15680699 PMID:17306896 RGD:2293876, RGD:2298577, RGD:2298567, RGD:2293875 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 ISO RGD PMID:17306896 RGD:2293875 NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181 		JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Map3k21 mitogen-activated protein kinase kinase kinase 21 ISO RGD PMID:17306896 RGD:2293875 NCBI chr19:53,880,032...53,913,560
Ensembl chr19:53,880,238...53,913,576 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:12215209 PMID:17306896 RGD:2293875 RGD:2296020 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map3k9 mitogen-activated protein kinase kinase kinase 9 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 6:101,423,754...101,488,822
Ensembl chr 6:101,430,292...101,488,822 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 ISO
IDA		 RGD PMID:17306896 PMID:15680699 PMID:10051439 RGD:2293875, RGD:2298567, RGD:2298561 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO
IDA		 RGD PMID:17306896 PMID:17064355 PMID:10051439 RGD:2293875, RGD:2298577, RGD:2298561 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO
IDA		 RGD PMID:17726577 PMID:15816852 RGD:2293880, RGD:1579811 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:17726577 RGD:2293880 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 ISO RGD PMID:17726577 RGD:2293880 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO
IDA		 RGD PMID:17306896 PMID:17064355 PMID:10051439 RGD:2293875, RGD:2298577, RGD:2298561 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876, RGD:2293879 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 IMP RGD PMID:10811109 RGD:11534984 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO RGD PMID:12215209 RGD:2296020 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      mitogen activated protein kinase signaling pathway 299
        stress-regulated MAPK signaling pathway 70
          c-Jun N-terminal kinases MAPK signaling pathway 31
            altered c-Jun N-terminal kinase MAPK signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      kinase mediated signaling pathway 601
        serine/threonine-specific kinase mediated signaling pathway 475
          mitogen activated protein kinase signaling pathway 299
            stress-regulated MAPK signaling pathway 70
              c-Jun N-terminal kinases MAPK signaling pathway 31
                altered c-Jun N-terminal kinase MAPK signaling pathway 0
paths to the root