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ONTOLOGY REPORT - ANNOTATIONS

Term:presynaptic modulation of chemical synaptic transmission
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Accession:GO:0099171 term browser browse the term
Definition:Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.


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presynaptic modulation of chemical synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 involved_in ISO (PMID:9547227) SynGO PMID:9547227 NCBI chr16:1,064,644...1,166,864
Ensembl chr16:1,037,162...1,167,094 		JBrowse link
G ADORA2A adenosine A2a receptor involved_in ISO PMID:15659214 SynGO PMID:15659214 RGD:1625642 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598 		JBrowse link
G ADORA2B adenosine A2b receptor involved_in ISO (PMID:25704806) SynGO PMID:25704806 NCBI chr 5:39,884,375...39,908,214 JBrowse link
G ADORA3 adenosine A3 receptor involved_in ISO PMID:8987783 SynGO PMID:8987783 RGD:13702310 NCBI chr17:63,895,408...63,898,666
Ensembl chr17:63,895,408...63,898,666 		JBrowse link
G ADRA1A adrenoceptor alpha 1A involved_in ISO PMID:12548707 SynGO PMID:12548707 RGD:13702265 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486 		JBrowse link
G ADRA2A adrenoceptor alpha 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 involved_in ISO PMID:17175110 SynGO PMID:17175110 RGD:5129150 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G APBA1 amyloid beta precursor protein binding family A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:87,787,039...87,980,204
Ensembl chr 1:87,786,836...87,980,194 		JBrowse link
G APBA2 amyloid beta precursor protein binding family A member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,243,086...38,431,491
Ensembl chr 3:38,243,102...38,430,887 		JBrowse link
G BACE1 beta-secretase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:16,308,953...16,319,100
Ensembl chr 5:16,308,944...16,319,100 		JBrowse link
G CHRD chordin involved_in ISO (PMID:17634368) MGI PMID:17634368 NCBI chr34:17,255,770...17,264,776
Ensembl chr34:17,255,562...17,271,713 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:11,515,727...11,665,651
Ensembl chr16:11,515,426...11,664,977 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit involved_in ISO PMID:12065717 SynGO PMID:12065717 RGD:13702272 NCBI chr13:38,330,287...38,343,142
Ensembl chr13:38,328,814...38,346,246 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit involved_in ISO (PMID:12944511) SynGO PMID:12944511 NCBI chr24:47,024,948...47,036,507
Ensembl chr24:47,025,187...47,042,266 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:38,343,966...38,355,534
Ensembl chr13:38,346,104...38,355,468 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit involved_in ISO (PMID:12944511) SynGO PMID:12944511 NCBI chr16:22,990,377...23,009,257
Ensembl chr16:22,990,167...23,009,106 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO PMID:21762741 SynGO PMID:21762741 RGD:13702307 NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit involved_in ISO (PMID:11145999), (PMID:12944511) SynGO PMID:11145999 PMID:12944511 NCBI chr 7:42,786,505...42,797,976
Ensembl chr 7:42,789,600...42,795,722 		JBrowse link
G CHRNB3 cholinergic receptor nicotinic beta 3 subunit involved_in ISO (PMID:14657161) SynGO PMID:14657161 NCBI chr16:23,021,652...23,040,907
Ensembl chr16:23,021,645...23,048,347 		JBrowse link
G CYTH1 cytohesin 1 involved_in ISO PMID:9927699 SynGO PMID:9927699 RGD:13702340 NCBI chr 9:2,636,553...2,677,356
Ensembl chr 9:2,605,084...2,675,661 		JBrowse link
G DGKI diacylglycerol kinase iota involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:10,975,394...11,250,430
Ensembl chr16:10,682,935...11,248,029 		JBrowse link
G DRD1 dopamine receptor D1 involved_in ISO (PMID:22586226) SynGO PMID:22586226 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287 		JBrowse link
G DRD2 dopamine receptor D2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
G DRD4 dopamine receptor D4 involved_in ISO PMID:24155292 SynGO PMID:24155292 RGD:13702381
G GIPC1 GIPC PDZ domain containing family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:48,144,076...48,155,069
Ensembl chr20:48,150,498...48,157,191 		JBrowse link
G GIT1 GIT ArfGAP 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:43,676,707...43,686,566
Ensembl chr 9:43,677,899...43,693,177 		JBrowse link
G GIT2 GIT ArfGAP 2 involved_in ISO (PMID:26637799) SynGO PMID:26637799 NCBI chr26:17,170,651...17,217,634
Ensembl chr26:17,170,680...17,214,631 		JBrowse link
G GLRA3 glycine receptor alpha 3 involved_in ISO (PMID:26851771) SynGO PMID:26851771 NCBI chr25:25,098,280...25,305,511
Ensembl chr25:25,131,250...25,305,027 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:11985817) MGI PMID:11985817 NCBI chr31:24,477,319...24,839,502
Ensembl chr31:24,478,696...24,839,434 		JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11985817) Ensembl
MGI		 PMID:11985817 GO_REF:0000107 NCBI chr12:58,932,754...59,991,305
Ensembl chr12:59,355,017...59,990,408 		JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:58,271,808...58,421,887
Ensembl chr11:58,273,377...58,421,761 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,915,178...37,926,276
Ensembl chr20:37,915,665...37,924,296 		JBrowse link
G GRM4 glutamate metabotropic receptor 4 involved_in ISO (PMID:8815915) SynGO PMID:8815915 NCBI chr12:3,346,395...3,459,722
Ensembl chr12:3,346,395...3,459,878 		JBrowse link
G GRM7 glutamate metabotropic receptor 7 involved_in ISO (PMID:12065412) SynGO PMID:12065412 NCBI chr20:10,230,568...11,058,693
Ensembl chr20:10,230,557...11,058,703 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 involved_in ISO PMID:15275822 SynGO PMID:15275822 RGD:6484726 NCBI chr14:8,982,180...9,719,813
Ensembl chr14:8,983,802...9,719,357 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666 		JBrowse link
G HIP1 huntingtin interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:6,957,760...7,115,676
Ensembl chr 6:6,961,053...7,115,618 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A involved_in ISO PMID:10381597 SynGO PMID:10381597 RGD:13702211 NCBI chr 2:50,005,277...50,006,548
Ensembl chr 2:50,002,740...50,006,548 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B involved_in ISO PMID:17067296 SynGO PMID:17067296 RGD:13702319 NCBI chr12:38,659,088...38,659,546 JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A involved_in ISO PMID:12196574 SynGO PMID:12196574 RGD:13702246 NCBI chr22:4,453,715...4,510,934
Ensembl chr22:4,453,715...4,511,037 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 involved_in ISO PMID:26779891 SynGO PMID:26779891 RGD:13702205 NCBI chr28:5,438,872...5,524,385
Ensembl chr28:5,440,388...5,524,191 		JBrowse link
G LAMP5 lysosomal associated membrane protein family member 5 involved_in ISO (PMID:27272053) SynGO PMID:27272053 NCBI chr24:12,678,209...12,693,847
Ensembl chr24:12,678,837...12,694,284 		JBrowse link
G MYO6 myosin VI involved_in ISO (PMID:16819522) SynGO PMID:16819522 NCBI chr12:37,359,200...37,502,342
Ensembl chr12:37,413,570...37,500,724 		JBrowse link
G NGFR nerve growth factor receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274 		JBrowse link
G NOG noggin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 involved_in ISO (PMID:18547242) SynGO PMID:18547242 NCBI chr15:46,390,030...46,718,000
Ensembl chr15:46,390,023...46,710,131 		JBrowse link
G NRN1 neuritin 1 involved_in ISO (PMID:28475719) SynGO PMID:28475719 NCBI chr35:6,070,456...6,079,214
Ensembl chr35:6,070,379...6,078,965 		JBrowse link
G NRXN2 neurexin 2 involved_in ISO (PMID:36608123) SynGO PMID:36608123 NCBI chr18:52,439,836...52,537,577
Ensembl chr18:52,439,230...52,536,401 		JBrowse link
G NRXN3 neurexin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:50,848,045...51,609,368
Ensembl chr 8:50,850,582...52,383,717 		JBrowse link
G OPRM1 opioid receptor mu 1 involved_in ISO (PMID:31818459) SynGO PMID:31818459 NCBI chr 1:43,972,915...44,037,477
Ensembl chr 1:43,972,219...44,141,238 		JBrowse link
G PFN2 profilin 2 involved_in ISO (PMID:17541406) SynGO PMID:17541406 NCBI chr23:44,686,126...44,691,801
Ensembl chr23:44,686,937...44,691,800 		JBrowse link
G PRKCA protein kinase C alpha involved_in ISO (PMID:21658591) SynGO PMID:21658591 NCBI chr 9:13,638,106...13,879,571
Ensembl chr 9:13,644,010...13,967,630 		JBrowse link
G PRKCB protein kinase C beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:21,742,970...22,064,360
Ensembl chr 6:21,742,973...22,065,185 		JBrowse link
G PRKCE protein kinase C epsilon involved_in ISO PMID:26625935 SynGO PMID:26625935 RGD:11353024 NCBI chr10:47,976,929...48,464,614
Ensembl chr10:47,976,768...48,535,296 		JBrowse link
G PRKCG protein kinase C gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:103,295,110...103,312,562 JBrowse link
G PTGER1 prostaglandin E receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:48,156,055...48,159,838
Ensembl chr20:48,157,973...48,159,921 		JBrowse link
G SYT12 synaptotagmin 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:50,334,779...50,358,113
Ensembl chr18:50,336,042...50,351,333 		JBrowse link
G TPRG1L tumor protein p63 regulated 1 like involved_in ISO PMID:26212709 SynGO PMID:26212709 RGD:13792549 NCBI chr 5:58,155,178...58,159,880
Ensembl chr 5:58,157,096...58,159,880 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in ISO (PMID:15543142) SynGO PMID:15543142 NCBI chr26:24,785,374...24,796,603
Ensembl chr26:24,785,368...24,795,778 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr20:52,955,949...52,966,279
Ensembl chr20:52,956,529...52,965,383 		JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:44,796,740...44,802,224
Ensembl chr20:44,796,895...44,801,692 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr11:51,707,968...51,941,148
Ensembl chr11:51,708,302...51,940,955 		JBrowse link
regulation of protein catabolic process at presynapse, modulating synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXL20 F-box and leucine rich repeat protein 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:23,021,103...23,122,768
Ensembl chr 9:23,021,468...23,135,297 		JBrowse link
regulation of translation at presynapse, modulating synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMR1 Fragile X messenger ribonucleoprotein 1 involved_in ISO PMID:24709664 SynGO PMID:24709664 RGD:11059581 NCBI chr  X:116,249,079...116,287,008
Ensembl chr  X:116,249,142...116,321,439 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17924
    regulation of biological process 12084
      regulation of signaling 3738
        regulation of trans-synaptic signaling 732
          modulation of chemical synaptic transmission 730
            presynaptic modulation of chemical synaptic transmission 65
              induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration 0
              regulation of presynaptic dense core granule exocytosis 4
              regulation of protein catabolic process at presynapse, modulating synaptic transmission 1
              regulation of translation at presynapse, modulating synaptic transmission 1
Path 2
Term Annotations click to browse term
  biological_process 17924
    biological regulation 12448
      regulation of biological process 12084
        signaling 6878
          cell-cell signaling 1465
            synaptic signaling 991
              trans-synaptic signaling 957
                anterograde trans-synaptic signaling 948
                  chemical synaptic transmission 948
                    modulation of chemical synaptic transmission 730
                      presynaptic modulation of chemical synaptic transmission 65
                        induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration 0
                        regulation of presynaptic dense core granule exocytosis 4
                        regulation of protein catabolic process at presynapse, modulating synaptic transmission 1
                        regulation of translation at presynapse, modulating synaptic transmission 1
paths to the root