ADCY1 (adenylate cyclase 1) - Rat Genome Database

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Gene: ADCY1 (adenylate cyclase 1) Canis lupus familiaris
Analyze
Symbol: ADCY1 (Ensembl: IGFBP1)
Name: adenylate cyclase 1
RGD ID: 12250821
Description: ENCODES a protein that exhibits calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN axonogenesis (ortholog); cAMP biosynthetic process (ortholog); circadian rhythm (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness 44 (ortholog); genetic disease (ortholog); Hyperkinesis (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate cyclase 1 (brain); adenylate cyclase type 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,064,644 - 1,166,864 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha16484,554 - 595,249 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha161,840,487 - 1,857,161 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,051,164 - 1,153,484 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,023,782 - 1,153,699 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,041,775 - 1,139,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016977,374 - 1,056,190 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01696,213 - 197,299 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADCY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,064,644 - 1,166,864 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha16484,554 - 595,249 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha161,840,487 - 1,857,161 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,051,164 - 1,153,484 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,023,782 - 1,153,699 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,041,775 - 1,139,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016977,374 - 1,056,190 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01696,213 - 197,299 (+)NCBIUU_Cfam_GSD_1.0
ADCY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,574,140 - 45,723,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,574,140 - 45,723,116 (+)EnsemblGRCh38hg38GRCh38
GRCh37745,613,739 - 45,762,715 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,580,646 - 45,729,237 (+)NCBINCBI36Build 36hg18NCBI36
Build 34745,387,360 - 45,535,952NCBI
Celera745,713,145 - 45,861,628 (+)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,497,881 - 45,646,668 (+)NCBIHuRef
CHM1_1745,617,991 - 45,766,937 (+)NCBICHM1_1
T2T-CHM13v2.0745,734,849 - 45,884,850 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,653,346 - 45,802,046 (+)NCBI
Adcy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,013,433 - 7,128,506 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,013,489 - 7,128,506 (+)EnsemblGRCm39 Ensembl
GRCm38117,063,433 - 7,178,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,063,489 - 7,178,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,963,492 - 7,078,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,963,492 - 7,078,509 (+)NCBIMGSCv36mm8
Celera117,538,560 - 7,653,962 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.72NCBI
Adcy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81486,125,119 - 86,234,459 (+)NCBIGRCr8
mRatBN7.21481,911,240 - 82,020,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,911,099 - 82,028,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1486,312,501 - 86,421,804 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,552,335 - 87,661,649 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,001,921 - 84,110,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,311,970 - 87,429,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,312,203 - 87,421,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,947,153 - 81,055,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,812,256 - 87,923,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,831,237 - 87,942,547 (+)NCBI
Celera1480,985,818 - 81,095,021 (+)NCBICelera
Cytogenetic Map14q21NCBI
Adcy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,841,637 - 6,930,990 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,833,992 - 6,930,990 (-)NCBIChiLan1.0ChiLan1.0
ADCY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,488,461 - 50,636,235 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1798,813,198 - 98,963,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,289,042 - 46,436,839 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,354,645 - 46,501,637 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl746,354,640 - 46,492,549 (+)Ensemblpanpan1.1panPan2
Adcy1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,098,778 - 101,252,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647820,310,503 - 20,456,141 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647820,310,509 - 20,477,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,051,364 - 50,143,628 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,043,572 - 50,143,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,887,477 - 54,978,872 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,976,687 - 13,117,876 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,979,033 - 13,117,730 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660629,421,819 - 9,563,930 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247406,922,879 - 7,003,658 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247406,915,445 - 7,003,299 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADCY1
2345 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 1 1 10 1 1 2 2 6 3
Below cutoff 4 4 12 5 6 5 4 4 8 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019469   ⟹   ENSCAFP00000018061
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,070,861 - 1,167,094 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000019512   ⟹   ENSCAFP00000018097
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,037,168 - 1,040,923 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000048834   ⟹   ENSCAFP00000038202
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,054,371 - 1,167,094 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073452   ⟹   ENSCAFP00000064175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,070,861 - 1,167,094 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000085269   ⟹   ENSCAFP00000053697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086530   ⟹   ENSCAFP00000048616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020105   ⟹   ENSCAFP00845015757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,023,782 - 1,153,699 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020259   ⟹   ENSCAFP00845015879
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,023,865 - 1,027,481 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020272   ⟹   ENSCAFP00845015890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,040,063 - 1,153,699 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020386   ⟹   ENSCAFP00845015978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,055,311 - 1,153,699 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020472   ⟹   ENSCAFP00845016052
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,055,311 - 1,153,699 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020543   ⟹   ENSCAFP00845016110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,058,381 - 1,153,699 (-)Ensembl
RefSeq Acc Id: XM_038452616   ⟹   XP_038308544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha16484,554 - 595,249 (-)NCBI
RefSeq Acc Id: XM_038452783   ⟹   XP_038308711
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha161,840,487 - 1,857,161 (-)NCBI
RefSeq Acc Id: XM_038498059   ⟹   XP_038353987
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1161,041,775 - 1,139,427 (-)NCBI
RefSeq Acc Id: XM_038559246   ⟹   XP_038415174
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01696,213 - 197,299 (+)NCBI
RefSeq Acc Id: XM_038623194   ⟹   XP_038479122
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.016977,374 - 1,056,190 (-)NCBI
RefSeq Acc Id: XM_038688955   ⟹   XP_038544883
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0161,051,164 - 1,153,484 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000064175   ⟸   ENSCAFT00000073452
RefSeq Acc Id: ENSCAFP00000038202   ⟸   ENSCAFT00000048834
RefSeq Acc Id: ENSCAFP00000018097   ⟸   ENSCAFT00000019512
RefSeq Acc Id: ENSCAFP00000018061   ⟸   ENSCAFT00000019469
RefSeq Acc Id: ENSCAFP00000048616   ⟸   ENSCAFT00000086530
RefSeq Acc Id: ENSCAFP00000053697   ⟸   ENSCAFT00000085269
RefSeq Acc Id: XP_038353987   ⟸   XM_038498059
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038479122   ⟸   XM_038623194
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038544883   ⟸   XM_038688955
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NHX6 (UniProtKB/TrEMBL),   A0A8C0N7F0 (UniProtKB/TrEMBL),   A0A8I3NK44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308544   ⟸   XM_038452616
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038308711   ⟸   XM_038452783
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038415174   ⟸   XM_038559246
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCAFP00845015879   ⟸   ENSCAFT00845020259
RefSeq Acc Id: ENSCAFP00845015890   ⟸   ENSCAFT00845020272
RefSeq Acc Id: ENSCAFP00845015757   ⟸   ENSCAFT00845020105
RefSeq Acc Id: ENSCAFP00845016110   ⟸   ENSCAFT00845020543
RefSeq Acc Id: ENSCAFP00845015978   ⟸   ENSCAFT00845020386
RefSeq Acc Id: ENSCAFP00845016052   ⟸   ENSCAFT00845020472
Protein Domains
Guanylate cyclase

Promoters
RGD ID:13686022
Promoter ID:EPDNEW_C4090
Type:single initiation site
Name:ADCY1_1
Description:adenylate cyclase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1161,166,947 - 1,167,007EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012249 Ensembl
  ENSCAFG00000056817 UniProtKB/TrEMBL
  ENSCAFG00030011653 UniProtKB/TrEMBL
  ENSCAFG00845011343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000103176.1 UniProtKB/TrEMBL
  ENSCAFT00030022367.1 UniProtKB/TrEMBL
  ENSCAFT00845020105.1 UniProtKB/TrEMBL
  ENSCAFT00845020272.1 UniProtKB/TrEMBL
  ENSCAFT00845020386 ENTREZGENE
  ENSCAFT00845020386.1 UniProtKB/TrEMBL
  ENSCAFT00845020472.1 UniProtKB/TrEMBL
  ENSCAFT00845020543.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
NCBI Gene ADCY1 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
Pfam AC_N UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/TrEMBL
UniProt A0A8C0N7F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NDW3_CANLF UniProtKB/TrEMBL
  A0A8I3NHX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NK44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RWF9_CANLF UniProtKB/TrEMBL
  A0A8I3RWH9_CANLF UniProtKB/TrEMBL
  A0A8P0PLL0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37618 ENTREZGENE