ADRA2A (adrenoceptor alpha 2A) - Rat Genome Database

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Pathways
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Gene: ADRA2A (adrenoceptor alpha 2A) Canis lupus familiaris
Analyze
Symbol: ADRA2A
Name: adrenoceptor alpha 2A
RGD ID: 12188532
Description: ENCODES a protein that exhibits alpha-1B adrenergic receptor binding (ortholog); alpha2-adrenergic receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); DNA replication (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); alcohol dependence (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN axon terminus (ortholog); dopaminergic synapse (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH clonidine; clonidine (amino form); clonidine (imino form)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,366,989 - 22,392,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,892,610 - 22,893,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IEA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting adrenergic receptor signaling pathway  (IEA)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adrenergic receptor signaling pathway  (IEA)
cellular response to hormone stimulus  (IEA)
DNA replication  (ISO)
fear response  (IEA,ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glucose homeostasis  (IEA)
negative regulation of calcium ion transport  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of insulin secretion  (IEA)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA)
negative regulation of lipid catabolic process  (IEA)
negative regulation of uterine smooth muscle contraction  (ISO)
phospholipase C-activating adrenergic receptor signaling pathway  (IEA)
platelet activation  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of potassium ion transport  (ISO)
positive regulation of wound healing  (IEA)
presynaptic modulation of chemical synaptic transmission  (IEA)
regulation of smooth muscle contraction  (IEA)
regulation of vasoconstriction  (IEA)
response to alcohol  (ISO)
response to morphine  (ISO)
thermoception  (ISO)
vasodilation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADRA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,366,989 - 22,392,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,892,610 - 22,893,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBIUU_Cfam_GSD_1.0
ADRA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810111,077,029 - 111,080,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10111,077,029 - 111,080,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,836,787 - 112,840,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,826,911 - 112,830,560 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410112,826,910 - 112,830,560NCBI
Celera10106,568,388 - 106,572,263 (+)NCBICelera
Cytogenetic Map10q25.2ENTREZGENE
HuRef10106,465,554 - 106,469,429 (+)NCBIHuRef
CHM1_110113,118,624 - 113,122,499 (+)NCBICHM1_1
T2T-CHM13v2.010111,960,874 - 111,964,752 (+)NCBIT2T-CHM13v2.0
Adra2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391954,033,690 - 54,037,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1954,032,582 - 54,037,413 (+)EnsemblGRCm39 Ensembl
GRCm381954,045,259 - 54,048,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1954,044,151 - 54,048,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv371954,119,672 - 54,123,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361954,098,545 - 54,102,294 (+)NCBIMGSCv36mm8
Celera1956,240,003 - 56,243,840 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1949.04NCBI
Adra2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81263,066,780 - 263,069,580 (+)NCBIGRCr8
mRatBN7.21253,061,480 - 253,064,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1253,060,218 - 253,064,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1261,250,961 - 261,253,761 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,957,040 - 267,959,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,612,912 - 260,615,708 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
Adra2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485385,800 - 387,240 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485384,405 - 387,332 (-)NCBIChiLan1.0ChiLan1.0
ADRA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,957,240 - 122,972,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,963,626 - 122,966,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,669,860 - 107,673,685 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110111,119,153 - 111,122,369 (+)NCBIpanpan1.1PanPan1.1panPan2
Adra2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,720,233 - 23,724,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,838,176 - 1,839,630 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,837,785 - 1,841,019 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,403,894 - 132,405,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19104,015,577 - 104,019,364 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9104,016,580 - 104,017,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604865,215,363 - 65,219,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,264,099 - 35,265,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADRA2A
275 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 7 1 1 6 6 6 1
Low 3 1 15 5 6 5 1 6 1 4 5
Below cutoff 4 5 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017233   ⟹   ENSCAFP00000015948
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051825   ⟹   ENSCAFP00845040665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2822,892,610 - 22,893,893 (+)Ensembl
RefSeq Acc Id: XM_038439683   ⟹   XP_038295611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBI
RefSeq Acc Id: XM_038460428   ⟹   XP_038316356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBI
RefSeq Acc Id: XM_038515661   ⟹   XP_038371589
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBI
RefSeq Acc Id: XM_038577959   ⟹   XP_038433887
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBI
RefSeq Acc Id: XM_038642139   ⟹   XP_038498067
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000015948   ⟸   ENSCAFT00000017233
RefSeq Acc Id: XP_038371589   ⟸   XM_038515661
RefSeq Acc Id: XP_038498067   ⟸   XM_038642139
RefSeq Acc Id: XP_038295611   ⟸   XM_038439683
- UniProtKB: A0A8I3Q7S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316356   ⟸   XM_038460428
- UniProtKB: A0A8P0ND24 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433887   ⟸   XM_038577959
- UniProtKB: A0A8P0ND24 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845040665   ⟸   ENSCAFT00845051825
Protein Domains
G-protein coupled receptors family 1 profile

Promoters
RGD ID:13688336
Promoter ID:EPDNEW_C6404
Type:single initiation site
Name:ADRA2A_1
Description:adrenoceptor alpha 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12822,367,684 - 22,367,744EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010840 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845029289 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017233.5 UniProtKB/TrEMBL
  ENSCAFT00845051825 ENTREZGENE
  ENSCAFT00845051825.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/TrEMBL
  ADRA2A_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene ADRA2A ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  ALPHA-2A ADRENERGIC RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ADRENERGICR UniProtKB/TrEMBL
  ADRENRGCA2AR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I3Q7S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0ND24 ENTREZGENE, UniProtKB/TrEMBL
  Q4ZHP8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:52983 ENTREZGENE