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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of Notch signaling pathway
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Accession:GO:0045746 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
Synonyms:exact_synonym: down regulation of Notch signaling pathway;   downregulation of Notch signaling pathway;   negative regulation of N signaling pathway;   negative regulation of N signalling pathway;   negative regulation of Notch signalling pathway
 narrow_synonym: inhibition of Notch signaling pathway


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negative regulation of Notch signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 involved_in ISO
ISS
IBA		 (PMID:23886940)
GO_REF:0000024
(MGI:5916812|PMID:23886940)
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:23886940 GO_REF:0000024 GO_REF:0000033 MGI:5916812 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrdc1 arrestin domain containing 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23886940)		 UniProt
RGD		 PMID:23886940 GO_REF:0000024 NCBI chr 3:7,735,002...7,742,195
Ensembl chr 3:7,735,011...7,742,197 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:1890504|MGI:97363 (PMID:23160044) RGD PMID:23160044 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bend6 BEN domain containing 6 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (MGI:5688817|PMID:25561495)
(PMID:23571214)
GO_REF:0000033		 RGD
GO_Central		 PMID:23571214 PMID:25561495 GO_REF:0000033 MGI:5688817 NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228 		JBrowse link
G Bmp7 bone morphogenetic protein 7 acts_upstream_of_or_within ISO MGI:1099809 (PMID:16324690) RGD PMID:16324690 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 involved_in ISO (MGI:5629454|PMID:25398765) RGD PMID:25398765 MGI:5629454 NCBI chr 3:142,936,945...143,043,205
Ensembl chr 3:142,936,985...143,043,197 		JBrowse link
G Ccnc cyclin C involved_in ISO
IEA		 (PMID:25344755)
GO_REF:0000107		 RGD
Ensembl		 PMID:25344755 GO_REF:0000107 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 involved_in ISO
ISS		 (PMID:22445366)
GO_REF:0000024		 RGD
UniProt		 PMID:22445366 GO_REF:0000024 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:25093684)
GO_REF:0000033
MGI:97363 (PMID:21419176)		 RGD
GO_Central		 PMID:21419176 PMID:25093684 GO_REF:0000033 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dlk2 delta like non-canonical Notch ligand 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:25093684)
MGI:97363 (PMID:21419176)
GO_REF:0000107		 RGD
Ensembl		 PMID:21419176 PMID:25093684 GO_REF:0000107 NCBI chr 9:14,677,102...14,681,584
Ensembl chr 9:14,676,562...14,681,594 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:16144902 GO_REF:0000033, RGD:1599776 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 involved_in ISO
IBA
IEA		 (MGI:5689216|PMID:26114479)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:26114479 GO_REF:0000033 GO_REF:0000107 MGI:5689216 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Dlx1 distal-less homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:94902 (PMID:23042297)		 Ensembl
RGD		 PMID:23042297 GO_REF:0000107 NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780 		JBrowse link
G Dlx2 distal-less homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:94901 (PMID:23042297)		 Ensembl
RGD		 PMID:23042297 GO_REF:0000107 NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597 		JBrowse link
G Egfl7 EGF-like-domain, multiple 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:20947685)
GO_REF:0000107		 RGD
Ensembl		 PMID:20947685 GO_REF:0000107 NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO (PMID:16672344) RGD PMID:16672344 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 involved_in
acts_upstream_of_or_within		 ISO (MGI:5299268|PMID:21943603)
MGI:5302017 (PMID:21943603), (PMID:22951639)		 RGD PMID:21943603 PMID:22951639 MGI:5299268 NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446 		JBrowse link
G Herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 acts_upstream_of_or_within ISO (PMID:26355680) RGD PMID:26355680 NCBI chr 1:106,904,789...107,110,997
Ensembl chr 1:106,880,084...107,108,134 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:18239137) RGD PMID:18239137 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO (MGI:3710697|PMID:11095750), (MGI:5284767|PMID:18239137) RGD PMID:11095750 PMID:18239137 MGI:3710697 MGI:5284767 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor involved_in ISO
IBA		 (PMID:18299578)
GO_REF:0000033		 RGD
GO_Central		 PMID:18299578 GO_REF:0000033 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327 		JBrowse link
G Kctd10 potassium channel tetramerization domain containing 10 acts_upstream_of_or_within ISO MGI:5751542 (PMID:25401743) RGD PMID:25401743 NCBI chr12:42,230,159...42,248,792
Ensembl chr12:42,230,269...42,248,783 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 acts_upstream_of_or_within ISO (PMID:26355680) RGD PMID:26355680 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mir1224 microRNA 1224 involved_in ISO (PMID:28717225) RGD PMID:28717225 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986 		JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5013661|PMID:21572390)		 UniProt
RGD		 PMID:21572390 GO_REF:0000024 MGI:5013661 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 involved_in ISO
IBA		 (PMID:20847082)
GO_REF:0000033		 RGD
GO_Central		 PMID:20847082 GO_REF:0000033 NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903 		JBrowse link
G Nfkbia NFKB inhibitor alpha acts_upstream_of_or_within ISO MGI:2176180|MGI:3577709 (PMID:15845452) RGD PMID:15845452 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Notch4 notch receptor 4 acts_upstream_of_or_within ISO (PMID:24667410) RGD PMID:24667410 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465 		JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:19154719)
MGI:5317888|MGI:97363 (PMID:12794108), (PMID:21795391), (PMID:21998026)
GO_REF:0000033		 RGD
GO_Central		 PMID:12794108 PMID:19154719 PMID:21795391 PMID:21998026 GO_REF:0000033 NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133 		JBrowse link
G Numb NUMB, endocytic adaptor protein acts_upstream_of_or_within ISO (PMID:21385765) RGD PMID:21385765 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Ovol2 ovo-like zinc finger 2 involved_in ISO (PMID:19700410) RGD PMID:19700410 NCBI chr 3:131,677,391...131,707,123
Ensembl chr 3:131,677,391...131,708,359 		JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IMP RGD PMID:11165380 RGD:633801 NCBI chr10:106,047,221...106,050,331
Ensembl chr10:106,047,221...106,050,345 		JBrowse link
G Rita1 RBPJ interacting and tubulin associated 1 involved_in ISO
IBA
ISS		 (PMID:21102556)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:21102556 GO_REF:0000024 GO_REF:0000033 NCBI chr12:35,950,090...35,953,960
Ensembl chr12:35,950,373...35,953,960 		JBrowse link
G Slc35c1 solute carrier family 35 member C1 acts_upstream_of_or_within ISO MGI:3709989 (PMID:20837470) RGD PMID:20837470 NCBI chr 3:78,421,925...78,429,603
Ensembl chr 3:78,421,933...78,428,520 		JBrowse link
G Tcim transcriptional and immune response regulator involved_in ISO (PMID:25985737) RGD PMID:25985737 NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581 		JBrowse link
G Tspan15 tetraspanin 15 involved_in ISO (PMID:30463011) RGD PMID:30463011 NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930 		JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3710692|PMID:17495164)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17495164 GO_REF:0000024 GO_REF:0000107 MGI:3710692 NCBI chr 7:8,561,015...8,578,243
Ensembl chr 7:8,563,779...8,576,539 		JBrowse link
negative regulation of Notch signaling pathway involved in somitogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5545944|PMID:23072809)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23072809 GO_REF:0000024 GO_REF:0000107 MGI:5545944 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    response to stimulus 10517
      negative regulation of response to stimulus 1849
        negative regulation of signal transduction 1446
          negative regulation of Notch signaling pathway 39
            negative regulation of Notch signaling pathway involved in somitogenesis 1
Path 2
Term Annotations click to browse term
  biological_process 19694
    biological regulation 13308
      regulation of biological process 12905
        signaling 7593
          signal transduction 7018
            cell surface receptor signaling pathway 2814
              Notch signaling pathway 193
                regulation of Notch signaling pathway 95
                  negative regulation of Notch signaling pathway 39
                    negative regulation of Notch signaling pathway involved in somitogenesis 1
paths to the root