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ONTOLOGY REPORT - ANNOTATIONS

Term:beta-catenin destruction complex
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Accession:GO:0030877 term browser browse the term
Definition:A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Comment:Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms:exact_synonym: APC-Axin-1-beta-catenin complex;   Axin-APC-beta-catenin-GSK3B complex;   BDC;   beta-catenin degradation complex
 narrow_synonym: 23S APC complex
 alt_id: GO:0034742;   GO:0034747


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beta-catenin destruction complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway part_of IEA
ISO
ISS
IBA		 GO_REF:0000107
(PMID:16188939), (PMID:8638126), (PMID:9601641)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000118		 Ensembl
RGD
UniProt
GO_Central
TreeGrafter		 PMID:8638126 PMID:9601641 PMID:16188939 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310 		JBrowse link
G Axin1 axin 1 part_of IDA
ISO
IEA
IBA		 PMID:10228155
(PMID:16188939), (PMID:19759537), (PMID:9601641)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118
(PMID:10318824)		 RGD
Ensembl
GO_Central
TreeGrafter		 PMID:9601641 PMID:10318824 PMID:16188939 PMID:19759537 PMID:10228155 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:8553327 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Cacybp calcyclin binding protein part_of ISO
IEA		 (PMID:16085652)
GO_REF:0000107		 RGD
Ensembl		 PMID:16085652 GO_REF:0000107 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 part_of ISO
ISS
IEA		 (PMID:11955436)
GO_REF:0000024
GO_REF:0000107		 RGD
ParkinsonsUK-UCL
Ensembl		 PMID:11955436 GO_REF:0000024 GO_REF:0000107 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Ctnnb1 catenin beta 1 part_of ISO
ISS
IEA		 (PMID:16188939), (PMID:8638126)
GO_REF:0000024
GO_REF:0000107
(PMID:10318824)		 RGD
UniProt
Ensembl		 PMID:8638126 PMID:10318824 PMID:16188939 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 part_of ISO
IBA		 (PMID:16188939)
GO_REF:0000033		 RGD
GO_Central		 PMID:16188939 GO_REF:0000033 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 located_in ISO (PMID:22470507) RGD PMID:22470507 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta part_of IDA
ISO
IEA
IBA		 PMID:10228155
(PMID:16188939), (PMID:8638126), (PMID:9601641)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118
(PMID:10318824)		 RGD
Ensembl
GO_Central
TreeGrafter		 PMID:8638126 PMID:9601641 PMID:10318824 PMID:16188939 PMID:10228155 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:8553327 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:16085652)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16085652 GO_REF:0000024 GO_REF:0000107 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      catalytic complex 1938
        beta-catenin destruction complex 11
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