Siah1 (siah E3 ubiquitin protein ligase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Siah1 (siah E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Siah1
Name: siah E3 ubiquitin protein ligase 1
RGD ID: 620449
Description: Enables ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Located in cytosol; early endosome; and nucleus. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; Wnt signaling pathway; INTERACTS WITH (-)-selegiline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase SIAH1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; seven in absentia homolog 1; SIAH; siah-1; siah-1a; Siah1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81936,552,165 - 36,575,773 (+)NCBIGRCr8
mRatBN7.21920,378,908 - 20,402,512 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1920,378,439 - 20,403,808 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1922,064,376 - 22,087,998 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01927,258,868 - 27,282,492 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01930,219,841 - 30,243,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01921,372,163 - 21,395,773 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1921,372,163 - 21,395,767 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01932,381,464 - 32,405,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41921,717,141 - 21,740,751 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11921,723,004 - 21,745,060 (+)NCBI
Celera1920,251,923 - 20,275,533 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-selegiline  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7-NITROINDAZOLE  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexachlorophene  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Hara MR, etal., Nat Cell Biol. 2005 Jul;7(7):665-74. Epub 2005 Jun 12.
3. Inhibiting a spinal cord signaling pathway protects against ischemia injury in rats. Huo J, etal., J Thorac Cardiovasc Surg. 2018 Jul 30. pii: S0022-5223(18)32035-X. doi: 10.1016/j.jtcvs.2018.07.045.
4. GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium. Huo J, etal., Neuroscience. 2016 Aug 25;330:171-80. doi: 10.1016/j.neuroscience.2016.05.054. Epub 2016 May 30.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Sen N, etal., Neuron. 2009 Jul 16;63(1):81-91. doi: 10.1016/j.neuron.2009.05.024.
11. Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation. Waites CL, etal., EMBO J. 2013 Apr 3;32(7):954-69. doi: 10.1038/emboj.2013.27. Epub 2013 Feb 12.
12. Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. Wheeler TC, etal., J Biol Chem 2002 Mar 22;277(12):10273-82.
13. Rat pancreatic colipase mRNA: nucleotide sequence of a cDNA clone and nutritional regulation by a lipidic diet. Wicker C and Puigserver A, Biochem Biophys Res Commun 1990 Feb 28;167(1):130-6.
14. Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis. Xu Z, etal., J Biol Chem. 2006 Jan 6;281(1):303-12. Epub 2005 Oct 17.
Additional References at PubMed
PMID:8889548   PMID:10469171   PMID:11389840   PMID:11686852   PMID:11863358   PMID:11884614   PMID:14506261   PMID:15326124   PMID:15996101   PMID:16085652   PMID:16615911   PMID:18065497  
PMID:18280659   PMID:19028597   PMID:19224863   PMID:19940145   PMID:21185211   PMID:21336655   PMID:21988832   PMID:22493164   PMID:23001567   PMID:25163685   PMID:25416956   PMID:31322210  
PMID:36307912  


Genomics

Comparative Map Data
Siah1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81936,552,165 - 36,575,773 (+)NCBIGRCr8
mRatBN7.21920,378,908 - 20,402,512 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1920,378,439 - 20,403,808 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1922,064,376 - 22,087,998 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01927,258,868 - 27,282,492 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01930,219,841 - 30,243,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01921,372,163 - 21,395,773 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1921,372,163 - 21,395,767 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01932,381,464 - 32,405,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41921,717,141 - 21,740,751 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11921,723,004 - 21,745,060 (+)NCBI
Celera1920,251,923 - 20,275,533 (+)NCBICelera
Cytogenetic Map19p11NCBI
SIAH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381648,360,531 - 48,387,246 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1648,356,364 - 48,448,402 (-)EnsemblGRCh38hg38GRCh38
GRCh371648,394,442 - 48,419,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361646,951,943 - 46,976,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 341646,951,946 - 46,954,901NCBI
Celera1632,903,789 - 32,928,589 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1634,285,181 - 34,290,523 (-)NCBIHuRef
CHM1_11649,802,241 - 49,826,886 (-)NCBICHM1_1
T2T-CHM13v2.01654,157,789 - 54,184,345 (-)NCBIT2T-CHM13v2.0
Siah1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39887,442,450 - 87,472,634 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl887,450,635 - 87,472,562 (-)EnsemblGRCm39 Ensembl
GRCm38886,720,454 - 86,746,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl886,724,007 - 86,745,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv37889,247,832 - 89,269,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36889,614,112 - 89,636,039 (-)NCBIMGSCv36mm8
Celera890,989,849 - 91,012,076 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map842.1NCBI
Siah1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554746,978,130 - 6,981,189 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554746,970,383 - 6,982,231 (+)NCBIChiLan1.0ChiLan1.0
SIAH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21857,821,104 - 57,845,436 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11663,727,001 - 63,750,803 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01628,627,021 - 28,651,343 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11647,517,587 - 47,542,447 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1647,517,594 - 47,522,936 (-)Ensemblpanpan1.1panPan2
SIAH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1266,630,795 - 66,709,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl266,657,696 - 66,708,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha263,206,954 - 63,285,647 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0267,189,150 - 67,267,733 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl267,210,394 - 67,268,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1264,002,793 - 64,081,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,026,052 - 65,104,768 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,914,309 - 65,992,717 (+)NCBIUU_Cfam_GSD_1.0
Siah1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934957,910,764 - 58,002,843 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364751,590,004 - 1,594,894 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364751,589,997 - 1,621,506 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIAH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl636,342,872 - 36,371,383 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1636,337,770 - 36,365,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2631,789,161 - 31,853,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIAH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1534,168,905 - 34,192,548 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl534,169,985 - 34,174,293 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604742,342,435 - 42,366,142 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Siah1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249142,166,958 - 2,193,357 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Siah1
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:165
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000020329
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
D19Rat111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21920,393,144 - 20,393,369 (+)MAPPERmRatBN7.2
Rnor_6.01921,386,406 - 21,386,630NCBIRnor6.0
Rnor_5.01932,395,707 - 32,395,931UniSTSRnor5.0
RGSC_v3.41921,731,383 - 21,731,608RGDRGSC3.4
RGSC_v3.41921,731,384 - 21,731,608UniSTSRGSC3.4
RGSC_v3.11921,736,209 - 21,736,434RGD
Celera1920,266,166 - 20,266,390UniSTS
Cytogenetic Map19p11UniSTS
RH136650  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21920,379,606 - 20,379,803 (+)MAPPERmRatBN7.2
Rnor_6.01921,372,862 - 21,373,058NCBIRnor6.0
Rnor_5.01932,382,163 - 32,382,359UniSTSRnor5.0
RGSC_v3.41921,717,840 - 21,718,036UniSTSRGSC3.4
Celera1920,252,622 - 20,252,818UniSTS
Cytogenetic Map19p11UniSTS
MARC_14423-14424:1010076472:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21920,400,900 - 20,401,300 (+)MAPPERmRatBN7.2
Rnor_6.01921,394,162 - 21,394,561NCBIRnor6.0
Rnor_5.01932,403,463 - 32,403,862UniSTSRnor5.0
RGSC_v3.41921,739,140 - 21,739,539UniSTSRGSC3.4
Celera1920,273,922 - 20,274,321UniSTS
Cytogenetic Map19p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 35 20 18 20 1 1 74 34 41 11 1
Low 10 22 21 1 21 7 10 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020329   ⟹   ENSRNOP00000020329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1920,385,910 - 20,402,766 (+)Ensembl
Rnor_6.0 Ensembl1921,372,163 - 21,395,767 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097354   ⟹   ENSRNOP00000092754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1920,379,658 - 20,403,808 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106824   ⟹   ENSRNOP00000096415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1920,397,743 - 20,401,598 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111812   ⟹   ENSRNOP00000089183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1920,378,796 - 20,403,808 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112896   ⟹   ENSRNOP00000092688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1920,378,439 - 20,403,808 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117078   ⟹   ENSRNOP00000088384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1920,397,743 - 20,403,318 (+)Ensembl
RefSeq Acc Id: NM_080905   ⟹   NP_543181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81936,552,165 - 36,575,773 (+)NCBI
mRatBN7.21920,378,908 - 20,402,512 (+)NCBI
Rnor_6.01921,372,163 - 21,395,773 (+)NCBI
Rnor_5.01932,381,464 - 32,405,074 (+)NCBI
RGSC_v3.41921,717,141 - 21,740,751 (+)RGD
Celera1920,251,923 - 20,275,533 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772345   ⟹   XP_008770567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81936,552,203 - 36,575,773 (+)NCBI
mRatBN7.21920,378,949 - 20,402,512 (+)NCBI
Rnor_6.01921,372,281 - 21,395,773 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097437   ⟹   XP_038953365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81936,552,507 - 36,575,773 (+)NCBI
mRatBN7.21920,379,103 - 20,402,512 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_543181   ⟸   NM_080905
- UniProtKB: Q920M9 (UniProtKB/Swiss-Prot),   A9UK92 (UniProtKB/TrEMBL),   A0A8I6APD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770567   ⟸   XM_008772345
- Peptide Label: isoform X1
- UniProtKB: Q920M9 (UniProtKB/Swiss-Prot),   A9UK92 (UniProtKB/TrEMBL),   A0A8I6APD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020329   ⟸   ENSRNOT00000020329
RefSeq Acc Id: XP_038953365   ⟸   XM_039097437
- Peptide Label: isoform X1
- UniProtKB: Q920M9 (UniProtKB/Swiss-Prot),   A9UK92 (UniProtKB/TrEMBL),   A0A8I6APD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096415   ⟸   ENSRNOT00000106824
RefSeq Acc Id: ENSRNOP00000089183   ⟸   ENSRNOT00000111812
RefSeq Acc Id: ENSRNOP00000092754   ⟸   ENSRNOT00000097354
RefSeq Acc Id: ENSRNOP00000088384   ⟸   ENSRNOT00000117078
RefSeq Acc Id: ENSRNOP00000092688   ⟸   ENSRNOT00000112896
Protein Domains
RING-type   SIAH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920M9-F1-model_v2 AlphaFold Q920M9 1-282 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700985
Promoter ID:EPDNEW_R11508
Type:initiation region
Name:Siah1_1
Description:siah E3 ubiquitin protein ligase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01921,372,156 - 21,372,216EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620449 AgrOrtholog
BioCyc Gene G2FUF-6230 BioCyc
Ensembl Genes ENSRNOG00000015143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019541 UniProtKB/Swiss-Prot
  ENSRNOG00060014793 UniProtKB/Swiss-Prot
  ENSRNOG00065010264 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020329.7 UniProtKB/Swiss-Prot
  ENSRNOT00000097354.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106824.1 UniProtKB/TrEMBL
  ENSRNOT00000111812.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112896 ENTREZGENE
  ENSRNOT00000112896.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117078.1 UniProtKB/Swiss-Prot
  ENSRNOT00055033349 UniProtKB/Swiss-Prot
  ENSRNOT00055033357 UniProtKB/Swiss-Prot
  ENSRNOT00055033362 UniProtKB/Swiss-Prot
  ENSRNOT00055033367 UniProtKB/Swiss-Prot
  ENSRNOT00055033370 UniProtKB/Swiss-Prot
  ENSRNOT00060025277 UniProtKB/Swiss-Prot
  ENSRNOT00060025283 UniProtKB/Swiss-Prot
  ENSRNOT00060025287 UniProtKB/Swiss-Prot
  ENSRNOT00060025289 UniProtKB/Swiss-Prot
  ENSRNOT00060025293 UniProtKB/Swiss-Prot
  ENSRNOT00065016573 UniProtKB/Swiss-Prot
  ENSRNOT00065016577 UniProtKB/Swiss-Prot
  ENSRNOT00065016583 UniProtKB/Swiss-Prot
  ENSRNOT00065016585 UniProtKB/Swiss-Prot
  ENSRNOT00065016590 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 7-in-absentia-prot_TRAF-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SINA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina-like_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_SIAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140941 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 140941 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SIAH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sina UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina_ZnF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Siah1 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SIAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015143 RatGTEx
  ENSRNOG00055019541 RatGTEx
  ENSRNOG00060014793 RatGTEx
  ENSRNOG00065010264 RatGTEx
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6APD1 ENTREZGENE, UniProtKB/TrEMBL
  A9UK92 ENTREZGENE, UniProtKB/TrEMBL
  Q920M9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q06984 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Siah1  siah E3 ubiquitin protein ligase 1  Siah1a  seven in absentia 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Siah1a  seven in absentia 1A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Siah1a  seven in absentia 1A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to both cytosolic and membrane-associated pools 633984