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ONTOLOGY REPORT - ANNOTATIONS

Term:COP9 signalosome
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Accession:GO:0008180 term browser browse the term
Definition:A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Synonyms:exact_synonym: CSN
 narrow_synonym: COP9 complex
 broad_synonym: signalosome


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COP9 signalosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G AMOT angiomotin located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr  X:112,774,877...112,840,831
Ensembl chr  X:112,774,503...112,840,831 		JBrowse link
G AMOTL1 angiomotin like 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr11:94,706,460...94,876,748
Ensembl chr11:94,706,431...94,876,748 		JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334 		JBrowse link
G BASP1 brain abundant membrane attached signal protein 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 5:17,216,823...17,276,834
Ensembl chr 5:17,065,598...17,276,843 		JBrowse link
G COPS2 COP9 signalosome subunit 2 part_of
located_in		 IEA
IBA
ISS
IPI
IDA		 (PMID:25043011)
(PMID:18850735), (PMID:9535219)		 Ensembl
GO_Central
TreeGrafter
ComplexPortal
UniProt		 PMID:9535219 PMID:18850735 PMID:25043011 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000114 GO_REF:0000118 NCBI chr15:49,122,727...49,155,599
Ensembl chr15:49,106,068...49,155,661 		JBrowse link
G COPS3 COP9 signalosome subunit 3 located_in
part_of		 IPI
IEA
IBA
ISS
IDA		 (PMID:25043011)
(PMID:18850735)		 ComplexPortal
TreeGrafter
GO_Central
Ensembl
UniProt		 PMID:18850735 PMID:25043011 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000114 GO_REF:0000118 NCBI chr17:17,246,616...17,281,246
Ensembl chr17:17,246,616...17,281,273 		JBrowse link
G COPS4 COP9 signalosome subunit 4 part_of
located_in		 IEA
IBA
ISS
IDA
IPI		 (PMID:18850735)
(PMID:25043011)		 Ensembl
TreeGrafter
GO_Central
ComplexPortal
UniProt		 PMID:18850735 PMID:25043011 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000114 GO_REF:0000118 NCBI chr 4:83,035,183...83,075,818
Ensembl chr 4:83,034,447...83,075,818 		JBrowse link
G COPS5 COP9 signalosome subunit 5 part_of
located_in		 IEA
IBA
ISS
IPI
IDA		 (PMID:25043011)
(PMID:18850735), (PMID:19214193)		 Ensembl
TreeGrafter
GO_Central
ComplexPortal
UniProt		 PMID:18850735 PMID:19214193 PMID:25043011 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000114 GO_REF:0000118 NCBI chr 8:67,043,079...67,062,133
Ensembl chr 8:67,043,079...67,083,783 		JBrowse link
G COPS6 COP9 signalosome subunit 6 located_in
part_of		 IPI
IBA
ISS
IEA
IDA		 (PMID:25043011)
(PMID:18850735)		 ComplexPortal
GO_Central
UniProt
InterPro
Ensembl		 PMID:18850735 PMID:25043011 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000114 NCBI chr 7:100,088,969...100,092,187
Ensembl chr 7:100,088,969...100,092,187 		JBrowse link
G COPS7A COP9 signalosome subunit 7A part_of
located_in		 IEA
IBA
IDA
IPI		 (PMID:18850735)
(PMID:25043011)		 UniProt
GO_Central
TreeGrafter
InterPro
ComplexPortal		 PMID:18850735 PMID:25043011 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 NCBI chr12:6,724,046...6,731,865
Ensembl chr12:6,724,014...6,731,875 		JBrowse link
G COPS7B COP9 signalosome subunit 7B part_of
located_in		 IDA
IBA
IEA
ISS		 (PMID:18850735) UniProt
GO_Central
TreeGrafter
InterPro
ComplexPortal		 PMID:18850735 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000114 GO_REF:0000118 NCBI chr 2:231,781,671...231,809,253
Ensembl chr 2:231,781,671...231,809,254 		JBrowse link
G COPS8 COP9 signalosome subunit 8 part_of
located_in		 IEA
IBA
ISS
IPI
IDA		 (PMID:25043011)
(PMID:18850735), (PMID:9535219)		 Ensembl
TreeGrafter
GO_Central
ComplexPortal
UniProt
InterPro		 PMID:9535219 PMID:18850735 PMID:25043011 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000114 GO_REF:0000117 GO_REF:0000118 NCBI chr 2:237,085,889...237,100,474
Ensembl chr 2:237,085,882...237,100,474 		JBrowse link
G COPS9 COP9 signalosome subunit 9 part_of
located_in		 IEA
IDA		 (PMID:23776465)
(PMID:26456823)		 UniProt PMID:23776465 PMID:26456823 GO_REF:0000043 NCBI chr 2:240,126,548...240,136,347
Ensembl chr 2:240,126,563...240,136,807 		JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 3:51,395,867...51,505,639
Ensembl chr 3:51,395,867...51,500,015 		JBrowse link
G DOCK7 dedicator of cytokinesis 7 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 1:62,454,726...62,688,386
Ensembl chr 1:62,454,298...62,688,386 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493 		JBrowse link
G EPB41L2 erythrocyte membrane protein band 4.1 like 2 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 6:130,839,347...131,063,245
Ensembl chr 6:130,839,347...131,063,322 		JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:27,612,064...27,635,185
Ensembl chr 1:27,612,064...27,635,185 		JBrowse link
G FLOT1 flotillin 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 6:30,727,709...30,742,687
Ensembl chr 6:30,727,709...30,742,732 		JBrowse link
G GPS1 G protein pathway suppressor 1 part_of
located_in		 IEA
IBA
ISS
IDA
IPI		 (PMID:18850735)
(PMID:25043011)		 UniProt
GO_Central
TreeGrafter
ComplexPortal		 PMID:18850735 PMID:25043011 GO_REF:0000033 GO_REF:0000043 GO_REF:0000114 GO_REF:0000118 NCBI chr17:82,050,932...82,057,470
Ensembl chr17:82,050,691...82,057,470 		JBrowse link
G GRAP GRB2 related adaptor protein part_of IBA GO_Central GO_REF:0000033 NCBI chr17:19,020,656...19,051,373
Ensembl chr17:19,020,656...19,047,011 		JBrowse link
G GRB2 growth factor receptor bound protein 2 part_of IDA
IEA
IBA		 (PMID:22561606) UniProt
TreeGrafter
GO_Central
Ensembl		 PMID:22561606 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709 		JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 6:31,809,619...31,815,283
Ensembl chr 6:31,809,619...31,815,283 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894 		JBrowse link
G HSPA7 heat shock protein family A (Hsp70) member 7 (pseudogene) located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 1:161,606,172...161,608,550
Ensembl chr 1:161,606,291...161,608,217 		JBrowse link
G LAT linker for activation of T cells part_of IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:28,984,803...28,990,784
Ensembl chr16:28,984,826...28,990,784 		JBrowse link
G MYH9 myosin heavy chain 9 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr22:36,281,280...36,387,967
Ensembl chr22:36,281,280...36,388,010 		JBrowse link
G NCKIPSD NCK interacting protein with SH3 domain located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 3:48,673,844...48,685,915
Ensembl chr 3:48,673,844...48,686,364 		JBrowse link
G PLCG1 phospholipase C gamma 1 part_of IDA (PMID:22561606) UniProt PMID:22561606 NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801 		JBrowse link
G SLA Src like adaptor part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:133,036,728...133,102,602
Ensembl chr 8:133,036,728...133,102,912 		JBrowse link
G TESPA1 thymocyte expressed, positive selection associated 1 part_of IEA
IDA		 (PMID:22561606) UniProt PMID:22561606 GO_REF:0000043 NCBI chr12:54,948,015...54,985,188
Ensembl chr12:54,948,015...54,984,762 		JBrowse link
G THEMIS thymocyte selection associated part_of IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:127,696,628...127,918,595
Ensembl chr 6:127,708,072...127,918,631 		JBrowse link
G TMOD1 tropomodulin 1 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 9:97,501,180...97,601,743
Ensembl chr 9:97,501,180...97,601,743 		JBrowse link
G WDR6 WD repeat domain 6 located_in IDA (PMID:18850735) UniProt PMID:18850735 NCBI chr 3:49,007,391...49,015,951
Ensembl chr 3:49,007,062...49,015,953 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20811
    protein-containing complex 7477
      nuclear protein-containing complex 1432
        COP9 signalosome 39
Path 2
Term Annotations click to browse term
  cellular_component 20811
    cellular anatomical entity 20424
      organelle 15599
        membrane-bounded organelle 14676
          intracellular membrane-bounded organelle 13442
            nucleus 8683
              nuclear protein-containing complex 1432
                COP9 signalosome 39
paths to the root