HSPA7 (heat shock protein family A (Hsp70) member 7 (pseudogene)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: HSPA7 (heat shock protein family A (Hsp70) member 7 (pseudogene)) Homo sapiens
Analyze
No known orthologs.
Symbol: HSPA7
Name: heat shock protein family A (Hsp70) member 7 (pseudogene)
RGD ID: 1349004
HGNC Page HGNC:5240
Description: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Located in COP9 signalosome.
Type: pseudo (Ensembl: unprocessed_pseudogene)
RefSeq Status: VALIDATED
Previously known as: heat shock protein family A (Hsp70) member 7; HSP70B
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,606,172 - 161,608,550 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,606,291 - 161,608,217 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,575,962 - 161,578,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,841,463 - 159,844,965NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map1q23.3NCBI
HuRef1132,819,217 - 132,821,703 (+)NCBIHuRef
CHM1_11162,997,661 - 163,000,153 (+)NCBICHM1_1
T2T-CHM13v2.01160,950,512 - 160,952,890 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1346391   PMID:3927293   PMID:8889548   PMID:11072087   PMID:12107410   PMID:17044073   PMID:17163517   PMID:17620599   PMID:17915554   PMID:17915556   PMID:18584345   PMID:18850735  
PMID:19380743   PMID:19875381   PMID:21145461   PMID:21873635   PMID:22190034   PMID:22516433   PMID:23349634   PMID:23443559   PMID:23533145   PMID:24244333   PMID:25544563   PMID:25756610  
PMID:25963833   PMID:26186194   PMID:28186131   PMID:28514442   PMID:29507755   PMID:29845934   PMID:30021884   PMID:30940648   PMID:30997501   PMID:31280863   PMID:31501420   PMID:31586073  
PMID:31980649   PMID:32838362   PMID:32963011   PMID:33961781   PMID:34354698   PMID:34857901   PMID:36215168   PMID:36380368   PMID:36574265   PMID:36584595   PMID:36811957   PMID:38113892  


Genomics

Variants

.
Variants in HSPA7
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.3-24.2(chr1:160789732-168617494)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|See cases [RCV000053913] Chr1:160789732..168617494 [GRCh38]
Chr1:160759522..168586732 [GRCh37]
Chr1:159026146..166853356 [NCBI36]
Chr1:1q23.3-24.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:277
Count of miRNA genes:229
Interacting mature miRNAs:244
Transcripts:ENST00000445535
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-X51758  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,577,996 - 161,578,199UniSTSGRCh37
GRCh371161,496,369 - 161,496,559UniSTSGRCh37
Build 361159,762,993 - 159,763,183RGDNCBI36
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1q23UniSTS
HuRef1132,821,385 - 132,821,575UniSTS
GeneMap99-GB4 RH Map1589.71UniSTS
RH70826  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,578,033 - 161,578,248UniSTSGRCh37
GRCh371161,496,406 - 161,496,608UniSTSGRCh37
Build 361159,763,030 - 159,763,232RGDNCBI36
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1q23UniSTS
HuRef1132,821,422 - 132,821,624UniSTS
GeneMap99-GB4 RH Map1576.12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 1 2
Medium 1409 1546 792 165 1084 72 2106 773 1004 105 406 983 94 1060 1187 1
Low 882 1401 850 407 703 338 1973 1316 2169 236 922 399 70 142 1551 1
Below cutoff 50 33 58 36 55 38 155 68 463 43 49 104 5 2 49

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000445535
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,606,291 - 161,608,217 (+)Ensembl
RefSeq Acc Id: NR_024151
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,606,172 - 161,608,550 (+)NCBI
GRCh371161,575,849 - 161,578,341 (+)ENTREZGENE
CHM1_11162,997,661 - 163,000,153 (+)NCBI
T2T-CHM13v2.01160,950,512 - 160,952,890 (+)NCBI
Sequence:
Protein Sequences
GenBank Protein P48741 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48741-F1-model_v2 AlphaFold P48741 1-367 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5240 AgrOrtholog
COSMIC HSPA7 COSMIC
Ensembl Genes ENSG00000225217 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000445535 ENTREZGENE
Gene3D-CATH 3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
GTEx ENSG00000225217 GTEx
HGNC ID HGNC:5240 ENTREZGENE
Human Proteome Map HSPA7 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
NCBI Gene 3311 ENTREZGENE
OMIM 140556 OMIM
PANTHER HEAT SHOCK 70 KDA PROTEIN 6-RELATED UniProtKB/Swiss-Prot
  PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PharmGKB PA29506 PharmGKB
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_1 UniProtKB/Swiss-Prot
  HSP70_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt HSP77_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P19790 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-18 HSPA7  heat shock protein family A (Hsp70) member 7 (pseudogene)  HSPA7  heat shock protein family A (Hsp70) member 7  Symbol and/or name change 5135510 APPROVED
2015-11-24 HSPA7  heat shock protein family A (Hsp70) member 7    heat shock 70kDa protein 7 (HSP70B)  Symbol and/or name change 5135510 APPROVED