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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of toll-like receptor signaling pathway
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Accession:GO:0034121 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
Synonyms:exact_synonym: regulation of TLR signaling pathway;   regulation of toll-like receptor signalling pathway


show annotations for term's descendants           Sort by:
regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056 		JBrowse link
G CD36 CD36 molecule involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G ESR1 estrogen receptor 1 acts_upstream_of_or_within ISO (PMID:22659029) MGI PMID:22659029 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:124,619,887...124,629,638
Ensembl chr 4:124,621,261...124,629,638 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in ISO (MGI:6158883|PMID:20616063) UniProt PMID:20616063 MGI:6158883 NCBI chr15:56,200,455...56,296,151
Ensembl chr15:56,200,455...56,295,064 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:26,363,808...26,384,933
Ensembl chr  X:26,365,027...26,384,760 		JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chr12:6,665,578...6,681,329 JBrowse link
G CD300LF CD300 molecule like family member f involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chr12:6,501,151...6,521,135 JBrowse link
negative regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SARM1 sterile alpha and TIR motif containing 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr12:44,654,364...44,676,942
Ensembl chr12:44,655,811...44,676,945 		JBrowse link
negative regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G CACTIN cactin, spliceosome C complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:75,049,250...75,065,990
Ensembl chr 2:75,049,261...75,065,299 		JBrowse link
G GPR108 G protein-coupled receptor 108 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,418,219...72,427,624
Ensembl chr 2:72,418,261...72,427,988 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,664,869...52,667,643
Ensembl chr12:52,664,875...52,667,610 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16236719) Ensembl
MGI		 PMID:16236719 GO_REF:0000107 NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609 		JBrowse link
G LGR4 leucine rich repeat containing G protein-coupled receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:32,871,837...32,979,150
Ensembl chr 2:32,871,871...32,979,148 		JBrowse link
G LRRC14 leucine rich repeat containing 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:279,756...287,085
Ensembl chr 4:279,764...287,062 		JBrowse link
G MIR140 microRNA mir-140 ISO RGD PMID:31376096 RGD:329337378 NCBI chr 6:17,077,530...17,077,599
Ensembl chr 6:17,077,507...17,077,620 		JBrowse link
G MIR17 microRNA mir-17 involved_in ISO (PMID:26041742) ARUK-UCL PMID:26041742 NCBI chr11:60,734,656...60,734,732
Ensembl chr11:60,734,656...60,734,732 		JBrowse link
G MIR19A microRNA mir-19a involved_in ISO (PMID:26041742) ARUK-UCL PMID:26041742 NCBI chr11:60,734,939...60,735,020
Ensembl chr11:60,734,939...60,735,020 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 involved_in ISS
IEA
IBA		 UniProt
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:23,673,002...23,685,089
Ensembl chr 7:23,669,595...23,685,087 		JBrowse link
G NLRP2B NLR family pyrin domain containing 2B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:59,186,265...59,186,402 JBrowse link
G NLRP6 NLR family pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22763455) Ensembl
MGI		 PMID:22763455 GO_REF:0000107 NCBI chr 2:90,001...97,441
Ensembl chr 2:90,027...97,439 		JBrowse link
G OTUD4 OTU deubiquitinase 4 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:83,240,759...83,288,237
Ensembl chr 8:83,240,754...83,288,234 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,432,058...39,512,601 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5487531|PMID:20728433) UniProt PMID:20728433 MGI:5487531 NCBI chr14:108,038,396...108,303,942
Ensembl chr14:108,039,431...108,303,929 		JBrowse link
G RNF115 ring finger protein 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:99,493,172...99,577,946
Ensembl chr 4:99,493,481...99,573,564 		JBrowse link
G SMPDL3B sphingomyelin phosphodiesterase acid like 3B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:85,060,639...85,084,483
Ensembl chr 6:85,060,317...85,084,480 		JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:129,811,540...129,829,395
Ensembl chr 1:129,811,544...129,829,014 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:47,601,133...47,645,327
Ensembl chr12:47,600,745...47,645,301 		JBrowse link
positive regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDI1 GDP dissociation inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:124,960,835...124,966,833
Ensembl chr  X:124,960,990...124,966,832 		JBrowse link
G LRCH4 leucine rich repeats and calponin homology domain containing 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,497,456...8,511,361
Ensembl chr 3:8,499,285...8,511,262 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5487531|PMID:20728433) UniProt PMID:20728433 MGI:5487531 NCBI chr14:108,038,396...108,303,942
Ensembl chr14:108,039,431...108,303,929 		JBrowse link
regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF1 interferon regulatory factor 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,129...134,783,801 		JBrowse link
G IRF7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378 		JBrowse link
regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    cellular process 16826
      signal transduction 6963
        regulation of signal transduction 3118
          regulation of pattern recognition receptor signaling pathway 169
            regulation of toll-like receptor signaling pathway 34
              negative regulation of toll-like receptor signaling pathway + 24
              positive regulation of toll-like receptor signaling pathway + 3
              regulation of MyD88-dependent toll-like receptor signaling pathway + 4
              regulation of MyD88-independent toll-like receptor signaling pathway + 2
              regulation of toll-like receptor 21 signaling pathway + 0
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to external stimulus 2556
        response to external biotic stimulus 1673
          response to other organism 1669
            defense response to other organism 1151
              defense response to symbiont 1034
                innate immune response 837
                  regulation of innate immune response 425
                    positive regulation of innate immune response 351
                      activation of innate immune response 287
                        innate immune response-activating signaling pathway 266
                          pattern recognition receptor signaling pathway 256
                            toll-like receptor signaling pathway 74
                              regulation of toll-like receptor signaling pathway 34
                                negative regulation of toll-like receptor signaling pathway + 24
                                positive regulation of toll-like receptor signaling pathway + 3
                                regulation of MyD88-dependent toll-like receptor signaling pathway + 4
                                regulation of MyD88-independent toll-like receptor signaling pathway + 2
                                regulation of toll-like receptor 21 signaling pathway + 0
paths to the root