SARM1 (sterile alpha and TIR motif containing 1) - Rat Genome Database

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Gene: SARM1 (sterile alpha and TIR motif containing 1) Sus scrofa
Analyze
Symbol: SARM1
Name: sterile alpha and TIR motif containing 1
RGD ID: 14194525
Description: ENCODES a protein that exhibits identical protein binding (ortholog); NAD+ nucleosidase activity (ortholog); NAD+ nucleotidase, cyclic ADP-ribose generating (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); NAD catabolic process (ortholog); nervous system process (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); genetic disease (ortholog); hereditary folate malabsorption (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); dendrite (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sterile alpha and TIR motif-containing protein 1; Tir-1 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,655,811 - 44,676,945 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,654,364 - 44,676,942 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,957 - 32,701 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:22366489   PMID:30032202  


Genomics

Comparative Map Data
SARM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,655,811 - 44,676,945 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,654,364 - 44,676,942 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,957 - 32,701 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SARM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,371,694 - 28,404,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,364,356 - 28,404,049 (+)EnsemblGRCh38hg38GRCh38
GRCh371726,698,715 - 26,731,067 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,723,114 - 23,752,192 (+)NCBINCBI36Build 36hg18NCBI36
Build 341723,723,252 - 23,752,192NCBI
Celera1723,560,746 - 23,589,829 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,907,093 - 22,936,406 (+)NCBIHuRef
CHM1_11726,761,617 - 26,790,977 (+)NCBICHM1_1
T2T-CHM13v2.01729,313,546 - 29,345,902 (+)NCBIT2T-CHM13v2.0
Sarm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,361,099 - 78,388,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,363,156 - 78,388,580 (-)EnsemblGRCm39 Ensembl
GRCm381178,470,273 - 78,497,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,472,330 - 78,497,754 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,285,832 - 78,311,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,289,486 - 78,313,898 (-)NCBIMGSCv36mm8
Celera1188,104,406 - 88,129,827 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Sarm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,867,503 - 63,890,872 (-)NCBIGRCr8
mRatBN7.21063,369,456 - 63,393,016 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,369,456 - 63,392,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,002,112 - 68,025,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,507,439 - 67,530,788 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,977,115 - 63,000,316 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,742,343 - 65,766,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,742,343 - 65,766,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,877,570 - 65,901,277 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,584,020 - 64,607,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,597,723 - 64,621,104 (-)NCBI
Celera1062,346,027 - 62,369,397 (-)NCBICelera
Cytogenetic Map10q25NCBI
Sarm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,743,458 - 4,763,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,743,458 - 4,763,766 (-)NCBIChiLan1.0ChiLan1.0
SARM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,060,284 - 36,088,474 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,940,656 - 37,967,563 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,370,206 - 28,403,440 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,878,498 - 28,905,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,878,498 - 28,905,363 (-)Ensemblpanpan1.1panPan2
SARM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,620,878 - 42,639,662 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,622,538 - 42,639,590 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,779,152 - 41,803,421 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,441,401 - 43,465,669 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,441,681 - 43,460,542 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,225,631 - 42,247,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,516,850 - 42,540,910 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,593,916 - 42,618,176 (+)NCBIUU_Cfam_GSD_1.0
Sarm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,648,738 - 41,672,956 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,526,582 - 4,545,896 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,526,713 - 4,546,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,137,990 - 22,163,431 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,138,588 - 22,162,893 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,963,131 - 7,992,410 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sarm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786974,876 - 997,956 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786974,785 - 1,001,810 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SARM1
869 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 9 4 3 4 2 23 2 3 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030474   ⟹   ENSSSCP00000025709
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1244,655,811 - 44,676,942 (+)Ensembl
RefSeq Acc Id: XM_003360057   ⟹   XP_003360105
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11244,654,364 - 44,676,942 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003360105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00015011016.1
  ENSSSCP00015011053.1
  ENSSSCP00040028943.1
  ENSSSCP00050001142.1
  ENSSSCP00060045261.1
GenBank Protein I3L5V6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_003360105   ⟸   XM_003360057
- UniProtKB: A0A8D1LCA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000025709   ⟸   ENSSSCT00000030474
Protein Domains
SAM   TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030358 Ensembl, ENTREZGENE
  ENSSSCG00015021236 UniProtKB/TrEMBL
  ENSSSCG00040050399 UniProtKB/TrEMBL
  ENSSSCG00050002625 UniProtKB/TrEMBL
  ENSSSCG00060075590 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030474 ENTREZGENE
  ENSSSCT00015028151.1 UniProtKB/TrEMBL
  ENSSSCT00015028238.1 UniProtKB/TrEMBL
  ENSSSCT00040068075.1 UniProtKB/TrEMBL
  ENSSSCT00050003341.1 UniProtKB/TrEMBL
  ENSSSCT00060103576.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100627920 UniProtKB/TrEMBL
NCBI Gene SARM1 ENTREZGENE
PANTHER NAD(+) HYDROLASE SARM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22998 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8D1LCA1 ENTREZGENE, UniProtKB/TrEMBL
  I3L5V6 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:99038 ENTREZGENE