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ONTOLOGY REPORT - ANNOTATIONS

Term:SCF ubiquitin ligase complex
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Accession:GO:0019005 term browser browse the term
Definition:A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms:exact_synonym: CDL1 complex;   CRL1 complex;   Cul1-RING ubiquitin ligase complex;   SCF complex;   Skp1/Cul1/F-box protein complex;   cullin-RING ligase 1
 narrow_synonym: SCF complex substrate recognition subunit
 xref: Wikipedia:SCF_complex


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SCF ubiquitin ligase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 part_of
located_in		 IEA
ISO		 (PMID:24076655), (PMID:27565346) Ensembl
UniProt		 PMID:24076655 PMID:27565346 GO_REF:0000107 NCBI chr15:51,423,132...51,534,278
Ensembl chr15:70,187,722...70,297,226 		JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase part_of IEA Ensembl GO_REF:0000107 NCBI chr10:97,958,527...98,159,550
Ensembl chr10:101,431,318...101,632,496 		JBrowse link
G CACYBP calcyclin binding protein part_of ISO (MGI:5882894|PMID:15996101) CAFA PMID:15996101 MGI:5882894 NCBI chr 1:150,511,021...150,522,369
Ensembl chr 1:154,210,001...154,220,583 		JBrowse link
G CCNF cyclin F part_of IEA Ensembl GO_REF:0000107 NCBI chr16:1,285,379...1,314,972
Ensembl chr16:2,529,371...2,556,438 		JBrowse link
G CKS1B CDC28 protein kinase regulatory subunit 1B part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:130,323,170...130,327,762
Ensembl chr 1:133,932,899...133,937,491 		JBrowse link
G CKS2 CDC28 protein kinase regulatory subunit 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 9:60,401,063...60,406,507
Ensembl chr 9:88,447,197...88,452,644 		JBrowse link
G CUL1 cullin 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:140,428,442...140,531,136
Ensembl chr 7:152,908,303...153,011,254 		JBrowse link
G CUL2 cullin 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr10:35,127,771...35,210,108
Ensembl chr10:35,704,964...35,787,014 		JBrowse link
G CUL5 cullin 5 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr11:102,895,611...102,994,447
Ensembl chr11:106,371,759...106,469,989 		JBrowse link
G FBH1 F-box DNA helicase 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr10:5,931,389...5,978,844
Ensembl chr10:5,915,713...5,962,778 		JBrowse link
G FBXL12 F-box and leucine rich repeat protein 12 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr19:9,362,764...9,371,547
Ensembl chr19:10,027,266...10,036,091 		JBrowse link
G FBXL13 F-box and leucine rich repeat protein 13 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 7:94,783,166...95,049,017
Ensembl chr 7:107,635,624...107,898,958 		JBrowse link
G FBXL14 F-box and leucine rich repeat protein 14 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr12:1,674,046...1,703,414
Ensembl chr12:1,626,802...1,655,056 		JBrowse link
G FBXL15 F-box and leucine rich repeat protein 15 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:99,022,732...99,026,623
Ensembl chr10:102,485,732...102,492,301 		JBrowse link
G FBXL17 F-box and leucine rich repeat protein 17 part_of ISO (PMID:24035498) UniProt PMID:24035498 NCBI chr 5:103,214,110...103,739,494 JBrowse link
G FBXL18 F-box and leucine rich repeat protein 18 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 7:5,734,703...5,770,942
Ensembl chr 7:5,751,134...5,789,134 		JBrowse link
G FBXL19 F-box and leucine rich repeat protein 19 part_of ISO (PMID:22660580) MGI PMID:22660580 NCBI chr16:24,020,365...24,046,217
Ensembl chr16:31,290,476...31,315,169 		JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:33,199,436...33,308,831
Ensembl chr 3:33,501,525...33,610,039 		JBrowse link
G FBXL20 F-box and leucine rich repeat protein 20 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:17,885,351...18,018,891
Ensembl chr17:18,098,172...18,285,524 		JBrowse link
G FBXL22 F-box and leucine rich repeat protein 22 part_of ISO PMID:22972877 MGI PMID:22972877 RGD:10400868 NCBI chr15:42,543,909...42,548,938
Ensembl chr15:60,837,032...60,841,829 		JBrowse link
G FBXL3 F-box and leucine rich repeat protein 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr13:58,219,260...58,244,780
Ensembl chr13:77,266,496...77,283,651 		JBrowse link
G FBXL4 F-box and leucine rich repeat protein 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 6:96,717,103...96,790,932
Ensembl chr 6:100,599,390...100,661,249 		JBrowse link
G FBXL5 F-box and leucine rich repeat protein 5 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:10,050,909...10,107,573
Ensembl chr 4:15,348,977...15,430,631 		JBrowse link
G FBXL7 F-box and leucine rich repeat protein 7 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:15,804,479...16,237,326
Ensembl chr 5:15,643,846...16,075,623 		JBrowse link
G FBXL8 F-box and leucine rich repeat protein 8 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr16:47,505,627...47,510,190
Ensembl chr16:66,896,147...66,898,044 		JBrowse link
G FBXO15 F-box protein 15 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr18:67,455,924...67,529,959
Ensembl chr18:70,740,443...70,814,441 		JBrowse link
G FBXO17 F-box protein 17 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:36,041,892...36,075,757
Ensembl chr19:44,590,799...44,624,871 		JBrowse link
G FBXO2 F-box protein 2 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:10,408,853...10,415,174
Ensembl chr 1:11,626,713...11,633,171 		JBrowse link
G FBXO25 F-box protein 25 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 8:6,931,217...6,995,138
Ensembl chr 8:344,220...384,077 		JBrowse link
G FBXO27 F-box protein 27 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:36,113,773...36,133,009
Ensembl chr19:44,675,354...44,681,541 		JBrowse link
G FBXO3 F-box protein 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr11:33,713,147...33,746,730
Ensembl chr11:33,594,854...33,628,399 		JBrowse link
G FBXO31 F-box protein 31 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:67,997,481...68,053,081
Ensembl chr16:87,322,364...87,377,104 		JBrowse link
G FBXO32 F-box protein 32 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:120,192,822...120,236,116
Ensembl chr 8:122,954,343...122,992,157 		JBrowse link
G FBXO36 F-box protein 36 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr2B:117,174,590...117,263,324
Ensembl chr2B:235,978,710...236,066,904 		JBrowse link
G FBXO4 F-box protein 4 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:68,336,673...68,474,481
Ensembl chr 5:73,500,850...73,517,051 		JBrowse link
G FBXO42 F-box protein 42 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:15,383,505...15,489,800
Ensembl chr 1:16,375,319...16,481,012 		JBrowse link
G FBXO44 F-box protein 44 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 1:11,632,768...11,640,846 JBrowse link
G FBXO45 F-box protein 45 part_of
NOT|part_of		 IEA
ISO		 (PMID:19398581) TreeGrafter
MGI		 PMID:19398581 GO_REF:0000118 NCBI chr 3:193,913,712...193,934,123
Ensembl chr 3:203,856,374...203,876,537 		JBrowse link
G FBXO48 F-box protein 48 part_of IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr2A:68,504,304...68,509,113
Ensembl chr2A:69,627,187...69,632,218 		JBrowse link
G FBXO6 F-box protein 6 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:10,414,856...10,436,406
Ensembl chr 1:11,643,009...11,654,837
Ensembl chr 1:11,643,009...11,654,837
Ensembl chr 1:11,643,009...11,654,837 		JBrowse link
G FBXO7 F-box protein 7 part_of IEA Ensembl GO_REF:0000107 NCBI chr22:13,481,255...13,505,301
Ensembl chr22:31,335,423...31,359,224 		JBrowse link
G FBXO9 F-box protein 9 part_of IEA InterPro
TreeGrafter
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:52,621,036...52,652,980
Ensembl chr 6:54,259,044...54,291,207 		JBrowse link
G FBXW11 F-box and WD repeat domain containing 11 part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:167,207,643...167,354,730
Ensembl chr 5:174,124,499...174,271,977 		JBrowse link
G FBXW4 F-box and WD repeat domain containing 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr10:98,212,907...98,297,477
Ensembl chr10:101,685,804...101,769,672 		JBrowse link
G FBXW5 F-box and WD repeat domain containing 5 part_of IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:107,998,949...108,003,247
Ensembl chr 9:136,969,957...136,973,945 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351 		JBrowse link
G FBXW8 F-box and WD repeat domain containing 8 part_of IEA Ensembl GO_REF:0000107 NCBI chr12:114,487,476...114,607,384
Ensembl chr12:117,863,254...117,983,269 		JBrowse link
G LOC100972235 putative F-box/LRR-repeat protein 21 part_of ISO (MGI:5470183|PMID:23452855), (MGI:5487698|PMID:23452856) UniProt PMID:23452855 PMID:23452856 MGI:5470183 MGI:5487698 NCBI chr 5:131,321,680...131,342,838 JBrowse link
G LOC100976386 cyclin-dependent kinases regulatory subunit 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr11:44,559,121...44,559,893
Ensembl chr 1:133,932,899...133,937,491 		JBrowse link
G LOC117974985 cyclin-dependent kinases regulatory subunit 1-like part_of IEA TreeGrafter GO_REF:0000118 NCBI chr11:78,272,730...78,273,720 JBrowse link
G LOC117975890 cyclin-dependent kinases regulatory subunit 1-like part_of IEA TreeGrafter GO_REF:0000118 NCBI chr14:76,833,061...76,854,334 JBrowse link
G LOC117977613 cyclin-dependent kinases regulatory subunit 1-like part_of IEA TreeGrafter GO_REF:0000118 NCBI chr  X:23,212,434...23,214,434 JBrowse link
G NCCRP1 NCCRP1, F-box associated domain containing part_of IEA TreeGrafter GO_REF:0000118 NCBI chr19:36,295,765...36,300,893
Ensembl chr19:44,844,711...44,848,796 		JBrowse link
G PNKP polynucleotide kinase 3'-phosphatase part_of ISO (MGI:5780352|PMID:26774286) UniProt PMID:26774286 MGI:5780352 NCBI chr19:46,874,216...46,880,954
Ensembl chr19:55,790,048...55,796,762 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase NOT|part_of ISO (PMID:12628165) ParkinsonsUK-UCL PMID:12628165 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G RBX1 ring-box 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr22:21,845,351...21,866,627
Ensembl chr22:39,941,405...39,962,175 		JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 part_of ISO (MGI:5882894|PMID:15996101) CAFA PMID:15996101 MGI:5882894 NCBI chr16:28,627,021...28,651,343
Ensembl chr16:47,517,594...47,522,936 		JBrowse link
G SKP1 S-phase kinase associated protein 1 part_of IEA UniProt GO_REF:0000104 NCBI chr 5:129,560,086...129,580,188
Ensembl chr 5:135,713,085...135,729,653 		JBrowse link
G SKP2 S-phase kinase associated protein 2 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:74,179,608...74,211,563
Ensembl chr 5:79,461,018...79,492,311 		JBrowse link
G SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:8,053,596...8,132,143
Ensembl chr 1:9,349,825...9,363,624 		JBrowse link
G SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr12:7,002,783...7,005,365
Ensembl chr12:6,914,159...6,916,554 		JBrowse link
G SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr16:399,090...405,020
Ensembl chr16:1,830,040...1,835,504 		JBrowse link
G SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:138,085,136...138,181,747
Ensembl chr 3:145,682,533...145,779,049 		JBrowse link
G TMEM183A transmembrane protein 183A part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:178,608,896...178,626,376
Ensembl chr 1:182,903,898...182,919,283 		JBrowse link
G TRIM21 tripartite motif containing 21 part_of
located_in		 IEA
ISO		 (PMID:16880511) Ensembl
UniProt		 PMID:16880511 GO_REF:0000107 NCBI chr11:4,588,083...4,596,942
Ensembl chr11:4,254,152...4,262,981 		JBrowse link
G USP47 ubiquitin specific peptidase 47 part_of IEA Ensembl GO_REF:0000107 NCBI chr11:12,009,770...12,127,425
Ensembl chr11:11,703,617...11,821,074 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17180
    protein-containing complex 5908
      intracellular protein-containing complex 882
        ubiquitin ligase complex 306
          cullin-RING ubiquitin ligase complex 183
            SCF ubiquitin ligase complex 66
              SCF-Cdc4 ubiquitin ligase complex 0
              SCF-Ctf13 ubiquitin ligase complex 0
              SCF-Das1 ubiquitin ligase complex 0
              SCF-Dia2/Pof3 ubiquitin ligase complex 0
              SCF-Grr1/Pof2 ubiquitin ligase complex 0
              SCF-Hrt3/Pof7 ubiquitin ligase complex 0
              SCF-Mdm30 ubiquitin ligase complex 0
              SCF-Met30/Pof1 ubiquitin ligase complex 0
              SCF-Pof5 ubiquitin ligase complex 0
              SCF-Rcy1/Pof6 ubiquitin ligase complex 0
              SCF-Saf1/Pof9 ubiquitin ligase complex 0
              SCF-Skp2 ubiquitin ligase complex 0
              SCF-Ucc1 ubiquitin ligase complex 0
              SCF-Ufo1/Pof10 ubiquitin ligase complex 0
              SCF-YDR131C ubiquitin ligase complex 0
              SCF-YLR352W ubiquitin ligase complex 0
              cytoplasmic SCF ubiquitin ligase complex 0
              nuclear SCF ubiquitin ligase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 17180
    protein-containing complex 5908
      catalytic complex 1708
        transferase complex 832
          ubiquitin ligase complex 306
            cullin-RING ubiquitin ligase complex 183
              SCF ubiquitin ligase complex 66
                SCF-Cdc4 ubiquitin ligase complex 0
                SCF-Ctf13 ubiquitin ligase complex 0
                SCF-Das1 ubiquitin ligase complex 0
                SCF-Dia2/Pof3 ubiquitin ligase complex 0
                SCF-Grr1/Pof2 ubiquitin ligase complex 0
                SCF-Hrt3/Pof7 ubiquitin ligase complex 0
                SCF-Mdm30 ubiquitin ligase complex 0
                SCF-Met30/Pof1 ubiquitin ligase complex 0
                SCF-Pof5 ubiquitin ligase complex 0
                SCF-Rcy1/Pof6 ubiquitin ligase complex 0
                SCF-Saf1/Pof9 ubiquitin ligase complex 0
                SCF-Skp2 ubiquitin ligase complex 0
                SCF-Ucc1 ubiquitin ligase complex 0
                SCF-Ufo1/Pof10 ubiquitin ligase complex 0
                SCF-YDR131C ubiquitin ligase complex 0
                SCF-YLR352W ubiquitin ligase complex 0
                cytoplasmic SCF ubiquitin ligase complex 0
                nuclear SCF ubiquitin ligase complex 0
paths to the root