FBXO2 (F-box protein 2) - Rat Genome Database

Name: FBXO2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: FBXO2 (F-box protein 2) Pan paniscus

Analyze

Symbol:

FBXO2

Name:

F-box protein 2

RGD ID:

11994156

Description:

ENCODES a protein that exhibits amyloid-beta binding (inferred); carbohydrate binding (inferred); denatured protein binding (inferred); INVOLVED IN ERAD pathway (ortholog); glycoprotein catabolic process (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); Familial Atrial Fibrillation 6 (ortholog); FOUND IN extrinsic component of postsynaptic membrane (ortholog); glutamatergic synapse (ortholog); postsynapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

F-box only protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBXO2 (F-box protein 2)	NCBI	Ortholog
Mus musculus (house mouse):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	216,571,838 - 216,577,899 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	215,217,956 - 215,224,017 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,408,853 - 10,415,174 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	11,626,713 - 11,633,171 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	11,626,713 - 11,633,171 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

chromosome 1p36 deletion syndrome (ISO)

Familial Atrial Fibrillation 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ERAD pathway (IEA,ISO)

glycoprotein catabolic process (IEA,ISO)

negative regulation of cell population proliferation (ISO)

protein ubiquitination (IEA)

regulation of protein catabolic process at postsynapse, modulating synaptic transmission (IEA)

regulation of protein ubiquitination (IEA,ISO)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IEA)

ubiquitin-dependent protein catabolic process (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

dendritic spine (IEA)

extrinsic component of postsynaptic membrane (ISO)

glutamatergic synapse (IEA,ISO)

postsynapse (ISO)

SCF ubiquitin ligase complex (IEA)

Molecular Function

amyloid-beta binding (IEA)

carbohydrate binding (IEA)

denatured protein binding (IEA)

protein binding (ISO)

ubiquitin protein ligase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FBXO2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	216,571,838 - 216,577,899 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	215,217,956 - 215,224,017 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,408,853 - 10,415,174 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	11,626,713 - 11,633,171 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	11,626,713 - 11,633,171 (-)	Ensembl	panpan1.1		panPan2

FBXO2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	11,648,387 - 11,654,429 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	11,637,018 - 11,655,785 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	11,708,444 - 11,714,486 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	11,631,035 - 11,637,326 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	11,642,715 - 11,649,005	NCBI
Celera	1	10,820,505 - 10,826,801 (-)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	10,862,510 - 10,868,984 (-)	NCBI		HuRef
CHM1_1	1	11,696,402 - 11,702,875 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,192,423 - 11,198,481 (-)	NCBI		T2T-CHM13v2.0

Fbxo2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	148,244,605 - 148,250,874 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	148,245,078 - 148,250,881 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	148,160,198 - 148,166,420 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,160,621 - 148,166,424 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	147,534,777 - 147,540,526 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	147,004,468 - 147,010,217 (+)	NCBI		MGSCv36	mm8
Celera	4	150,422,125 - 150,427,887 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	78.68	NCBI

Fbxo2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,876,079 - 163,881,508 (+)	NCBI		GRCr8
mRatBN7.2	5	158,592,926 - 158,598,355 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,592,925 - 158,598,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	161,309,703 - 161,315,130 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,131,494 - 163,136,941 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	163,087,839 - 163,093,286 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	164,972,483 - 164,977,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,972,480 - 164,977,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	168,630,521 - 168,635,950 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	165,239,080 - 165,244,509 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	165,249,267 - 165,254,697 (+)	NCBI
Celera	5	156,871,142 - 156,876,571 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Fbxo2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,212,001 - 2,218,017 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	2,212,001 - 2,217,260 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBXO2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,563,256 - 84,568,507 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,556,547 - 84,568,491 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	81,095,467 - 81,100,690 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	85,226,074 - 85,231,298 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	85,226,182 - 85,231,052 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,975,039 - 81,980,259 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,975,760 - 82,980,978 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	84,038,529 - 84,043,752 (+)	NCBI		UU_Cfam_GSD_1.0

Fbxo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	34,696,457 - 34,701,333 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	521,123 - 526,959 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	521,235 - 526,151 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXO2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	71,740,677 - 71,748,923 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	71,740,647 - 71,747,265 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	65,660,557 - 65,663,671 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXO2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	120,136,630 - 120,144,119 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	120,136,702 - 120,144,258 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	24,005,047 - 24,011,590 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxo2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	1,299,067 - 1,309,667 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	1,300,191 - 1,311,245 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003822076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034955401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000055461 ⟹ ENSPPAP00000032592

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	11,626,713 - 11,633,171 (-)	Ensembl

RefSeq Acc Id:

XM_003822076 ⟹ XP_003822124

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	216,571,838 - 216,577,899 (+)	NCBI
NHGRI_mPanPan1	1	215,217,956 - 215,224,017 (+)	NCBI
Mhudiblu_PPA_v0	1	10,408,853 - 10,415,174 (-)	NCBI
PanPan1.1	1	11,626,713 - 11,633,171 (-)	NCBI

Sequence:

show sequence

GCGCAGCGCTGGGCCAGGGACGCACCCCCACCGCGTCGTAGGAAAATTACCTGGTGTGGGGGGT
GGGGCGGAAGGCACCTCCTATACCCCGACTCCGCCTGGGCCACCCGCCCCGCACCCTCGGCCTG
ACCCAGCCTCTCCGTGCCTCCCCTAGCCGCCTCCTCCCAGCAGTCCCCCAGGAGCGAGCTGCGA
GATGCCCCAAATCGGACCCCTCCCCAGCTGGAAAAAAAACGACTCCTGACCTTTCCCAGCCTCC
TCGGTCCGCTGAGGAACCCGCAGCCCCGGGCCTCGAGCAGACTGCTGGGACTGCGGGGCGGCCG
GGCGCGGGGCCAGAGGCGGGGCGGGGCGGGGCGGGTCGGGTCGGGGGCCTTTAAGAGGCGCGGT
CGCCGGGACCGACACAGACGCGGACAGCGCCGGGACTCGCCGCCCCGGGACTCGCGCAGCCCGC
AGCGCTCCGGCTCCTCCTTCTCTCGCGACCGCCCTCCGCAGCGATGGACGGAGACGGTGACCCA
GAGAGCGTGGGCCAGCCCGAGGAGGCAAGCCCGGAGGAGCAGCCAGAGGAGGCGAGTGCTGAGG
AGGAGCGGCTGGAGGACCAGGAGGAGGAGGAGGCGGCGGCCGCCGCGTACCTGGACGAGCTGCC
CGAGCCGCTGCTGCTGCGCGTGCTGGCCGCACTGCCGGCCGCCGAGCTGGTGCAGGCCTGCCGC
CTGGTGTGCCTGCGCTGGAAGGAGCTGGTGGACGGCGCCCCGCTGTGGCTGCTCAAGTGCCAGC
AGGAGGGGCTGGTGCCCGAGGGCGGCGTGGAGGAGGAGCGCGACCACTGGCAGCAGTTCTACTT
CCTGAGCAAGCGGCGCCGCAACCTTCTGCGTAACCCGTGTGGGGAAGAGGACTTGGAAGGCTGG
TGTGACGTGGAGCATGGTGGGGACGGCTGGAGGGTGGAGGAGCTGCCTGGAGACAGTGGGGTGG
AGTTCACCCACGATGAGAGCGTCAAGAAGTACTTCGCCTCCTCCTTTGAGTGGTGTCGCAAAGC
ACAGGTGATTGACCTGCAGGCTGAGGGCTACTGGGAGGAGCTGCTGGACACGACTCAGCCGGCC
ATCGTGGTGAAGGACTGGTACTCGGGCCGCAGCGACGCTGGTTGCCTCTACGAGCTCACCGTTA
AGCTACTGTCCGAGCACGAGAACGTGCTGGCTGAGTTCAGCAGCGGGCAGGTGGCAGTGCCCCA
AGACAGTGACGGCGGGGGCTGGATGGAGATCTCCCACACCTTCACCGACTACGGGCCGGGCGTC
CGCTTCGTCCGCTTCCAGCACGGGGGGCAGGACTCCGTCTACTGGAAGGGCTGGTTCGGGGCCC
GGGTGACCAACAGCAGCGTGTGGGTAGAACCCTGAGCGACCCTGCCTCCACTCTCCCCCAGCTG
CCTGGAGGGGCAAAGGTCGAGGGTAGATAGGCCTTAACTTAGTCCATAGCGTCCTCACCTTCCC
CAAGCCACACATCCTCCTGCCATCCCTTGCTCCGATCCCAGCCCCTGAGCAGGGAGAGAGAAGT
TTTGTTGGCATAGGTTTGCTTAGGTAGCCGGCTTCTAGAATGTAGATCCGTGAGGGCGTGAGCT
TGGACTGGACCCACTGCTGAATCCCCTGCACCTAGCACAGTGCCTGCCACAAAGTGGGCTCTCA
ATAAATATTATTTGTCCAAGGAAGGAATGAATGAACAAATGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003822124	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032592
	ENSPPAP00000032592.1

RefSeq Acc Id:

XP_003822124 ⟸ XM_003822076

- UniProtKB:

A0A2R9BSE6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDGDGDPESVGQPEEASPEEQPEEASAEEERLEDQEEEEAAAAAYLDELPEPLLLRVLAALPAA
ELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLRNPCG
EEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDESVKKYFASSFEWCRKAQVIDLQAEGYWEEL
LDTTQPAIVVKDWYSGRSDAGCLYELTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTF
TDYGPGVRFVRFQHGGQDSVYWKGWFGARVTNSSVWVEP

hide sequence

RefSeq Acc Id:

ENSPPAP00000032592 ⟸ ENSPPAT00000055461

Protein Domains

F-box FBA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039179	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000055461.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1280.50	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
InterPro	F-box-assoc_dom	UniProtKB/TrEMBL
	F-box-like_dom_sf	UniProtKB/TrEMBL
	F-box_dom	UniProtKB/TrEMBL
	F-box_only	UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/TrEMBL
KEGG Report	pps:100978053	UniProtKB/TrEMBL
NCBI Gene	FBXO2	ENTREZGENE
PANTHER	F-BOX ONLY PROTEIN 2	UniProtKB/TrEMBL
	PTHR12125	UniProtKB/TrEMBL
Pfam	F-box-like	UniProtKB/TrEMBL
	FBA	UniProtKB/TrEMBL
PROSITE	FBA	UniProtKB/TrEMBL
	FBOX	UniProtKB/TrEMBL
SMART	FBA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49785	UniProtKB/TrEMBL
	SSF81383	UniProtKB/TrEMBL
UniProt	A0A2R9BSE6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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