FBXW4 (F-box and WD repeat domain containing 4)

Gene: FBXW4 (F-box and WD repeat domain containing 4) Pan paniscus

Analyze

Symbol:

FBXW4

Name:

F-box and WD repeat domain containing 4

RGD ID:

11703515

Description:

INVOLVED IN cartilage development (ortholog); embryonic digit morphogenesis (ortholog); limb development (ortholog); ASSOCIATED WITH split hand-foot malformation (ortholog); split hand-foot malformation 3 (ortholog); FOUND IN SCF ubiquitin ligase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

F-box/WD repeat-containing protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	113,496,596 - 113,581,162 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	113,501,913 - 113,586,510 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	98,212,907 - 98,297,477 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	101,685,804 - 101,769,277 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	101,685,804 - 101,769,672 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

split hand-foot malformation (ISO)

split hand-foot malformation 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cartilage development (IEA,ISO)

embryonic digit morphogenesis (IEA,ISO)

limb development (IEA,ISO)

positive regulation of mesenchymal cell proliferation (IEA,ISO)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

SCF ubiquitin ligase complex (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FBXW4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	113,496,596 - 113,581,162 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	113,501,913 - 113,586,510 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	98,212,907 - 98,297,477 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	101,685,804 - 101,769,277 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	101,685,804 - 101,769,672 (-)	Ensembl	panpan1.1		panPan2

FBXW4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	101,610,666 - 101,695,295 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	101,610,664 - 101,695,295 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	103,370,423 - 103,455,052 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	103,360,411 - 103,444,733 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	97,109,207 - 97,193,536 (-)	NCBI		Celera
Cytogenetic Map	10	q24.32	NCBI
HuRef	10	97,000,717 - 97,084,921 (-)	NCBI		HuRef
CHM1_1	10	103,654,100 - 103,738,441 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	102,494,739 - 102,578,296 (-)	NCBI		T2T-CHM13v2.0

Fbxw4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	45,566,693 - 45,648,954 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	45,566,693 - 45,648,751 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	45,578,254 - 45,660,520 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	45,578,254 - 45,660,312 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	45,652,747 - 45,734,683 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	45,631,568 - 45,713,504 (-)	NCBI		MGSCv36	mm8
Celera	19	46,345,905 - 46,428,364 (-)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	38.75	NCBI

Fbxw4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	254,375,921 - 254,465,173 (-)	NCBI		GRCr8
mRatBN7.2	1	244,426,892 - 244,514,188 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	244,426,896 - 244,514,163 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	252,568,588 - 252,655,050 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	259,271,799 - 259,352,963 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	251,918,142 - 252,005,105 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	265,318,526 - 265,420,503 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	265,318,526 - 265,420,503 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	270,474,853 - 270,499,913 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	250,746,869 - 250,874,460 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	251,007,474 - 251,135,492 (-)	NCBI
Celera	1	240,235,760 - 240,322,798 (-)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

Fbxw4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	8,584,836 - 8,669,705 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955485	8,584,836 - 8,688,416 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBXW4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	14,219,724 - 14,336,846 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	14,219,893 - 14,301,924 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	14,388,454 - 14,505,308 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	14,687,904 - 14,804,731 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	14,688,073 - 14,769,794 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	14,232,621 - 14,351,242 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	14,274,140 - 14,390,820 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	14,406,279 - 14,523,118 (-)	NCBI		UU_Cfam_GSD_1.0

Fbxw4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	32,469,518 - 32,558,996 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	4,073,384 - 4,161,588 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	4,072,749 - 4,162,220 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXW4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	112,638,204 - 112,736,056 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	112,628,988 - 112,736,631 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	122,381,573 - 122,481,033 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXW4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	94,634,721 - 94,722,156 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	94,635,347 - 94,721,439 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	55,710,938 - 55,797,860 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxw4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624831	1,107,689 - 1,183,958 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624831	1,107,689 - 1,183,839 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003825689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055093299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000028492 ⟹ ENSPPAP00000006792

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	101,685,804 - 101,769,281 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000028509 ⟹ ENSPPAP00000006802

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	101,686,431 - 101,769,672 (-)	Ensembl

RefSeq Acc Id:

XM_003825689 ⟹ XP_003825737

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	113,496,596 - 113,581,162 (-)	NCBI
NHGRI_mPanPan1	10	113,501,913 - 113,586,491 (-)	NCBI
Mhudiblu_PPA_v0	10	98,212,907 - 98,297,452 (-)	NCBI
PanPan1.1	10	101,685,804 - 101,769,277 (-)	NCBI

Sequence:

show sequence

GGCGCCTGCCGGAGGAGCTGCTGCTGCTCATCTGCTCCTACCTGGACATGCGGGCCCTCGGCCG
CCTGGCCCAGGTGTGCCGCTGGCTGCGGCGCTTCACCAGCTGCGATCTGCTCTGGCGCCGGATA
GCCCGGGCCTCGCTCAACTCCGGCTTCACGCGGCTCGGCACCGACCTGATGACCAGTGTCCCAG
TGAAGGAACGAGTGAAGGTGTCTCAGAACTGGAGACTGGGGCGCTGCCGAGAGGGGATTCTGCT
GAAGTGGAGATGCAGTCAGATGCCCTGGATGCAGCTAGAGGATGATTCTCTGTACATATCCCAG
GCTAATTTCATCCTGGCCTACCAGTTCCGTCCAGATGGTGCCAGCTTGAATCGTCGGCCTCTGG
GAGTCTTTGCTGGGCATGATGAGGACGTTTGCCACTTTGTGCTGGCCAACTCGCATATTATTAG
TGCAGGAGGAGATGGGAAGATTGGCATTCATAAGATTCACAGCACCTTCACTGTCAAGTACTCG
GCTCATGAACAGGAGGTGAACTGTGTGGATTGCAAAGGGGGCATCATTGTGAGTGGCTCCAGGG
ACAGGACGGCCAAGGTGTGGCCTTTGGCCTCAGGCCGGCTGGGGCAGTGCTTACACACCATCCA
GACTGAAGACCGAGTCTGGTCCATTGCTATCAGCCCATTACTCAGCTCTTTTGTGACAGGGACG
GCTTGTTGCGGGCACTTCTCACCCCTGAGAATCTGGGACCTCAACAGTGGGCAGCTGATGACAC
ACTTGGGCAGTGACTTTCCCCCAGGGGCTGGGGTGCTGGATGTCATGTATGAATCCCCTTTCAC
ACTGCTGTCCTGTGGCTATGACACCTATGTTCGCTACTGGGACCTCCGCACCAGTGTCCGGAAA
TGTGTCATGGAGTGGGAGGAGCCCCACGACAGCACCCTGTACTGCCTGCAGACAGATGGCAACC
ACCTTCTGGCCACAGGTTCCTCCTACTACGGTGTTGTACGGCTGTGGGACCGGCGTCAAAGGGC
CTGCCTGCACGCCTTCCCGCTGACGTCGACTCCCCTCAGCAGCCCTGTGTACTGCCTGCGTCTC
ACCACCAAGCATCTCTATGCTGCACTGTCTTACAACCTCCACGTCCTGGATTTTCAAAACCCAT
GACCGTCAGGGCCACCCCTGCCTCTGGGCCAGGGAAACCAGCTACTCAGGGACTTCTCTTGCCT
GGAGGGTACAGTGATAGCTCCTCCTCACTGCCCCACTGTGCTCCTGGGCCTGTGACCCCAGTGC
TCAGGCACCTTGCACTAGAGGCTTCTGACTCCTGGGACTTTGGAGCTTACCAGAGATGCAGTCC
CTCCCAGGAACCTGTTGGAGAGGCAGGACCTGCTGCTTTAGAGTGTGGCTGAACCCGGGCCTTG
CGTCCCTGTTTGGCCAGAGCAAGGATCTGGCCTGGAGAGGCCCACCCTATACCCCTTATTAGAG
CCATGACAGCCTACAGAGTGAGGTGAGGTGCTCCCACCTTCCCAGATGGTTTCTTTCTGCCCCT
TCCTGGAAGGAAAGGTGAGGCTGCCAATAGCCTCCTGGCACCAGCCAGACCTCACCCTTGACCA
ACCTCTTGGGGCTGGGGGTTCATTCCTGGGGCACTGTGGCCTGGTTTTGCTTTGAAACCAAGAA
AGAGCAAAGGGAACCCAGCAGTTCTGAGTGAGTTCTGAGCCAGCCCTACCTCAGGCTGGCTGTT
GAGACATGCTACAATTTTCATTTTTGTAAAAATAAAGCTTGATTGTTCACAGA

hide sequence

RefSeq Acc Id:

XM_055093299 ⟹ XP_054949274

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	113,496,596 - 113,580,845 (-)	NCBI
NHGRI_mPanPan1	10	113,501,913 - 113,586,498 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003825737	(Get FASTA)	NCBI Sequence Viewer
	XP_054949274	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000006792.1
	ENSPPAP00000006802.1

RefSeq Acc Id:

XP_003825737 ⟸ XM_003825689

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRC
REGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLA
NSHIISAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQ
CLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM
YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLW
DRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

hide sequence

RefSeq Acc Id:

ENSPPAP00000006792 ⟸ ENSPPAT00000028492

RefSeq Acc Id:

ENSPPAP00000006802 ⟸ ENSPPAT00000028509

RefSeq Acc Id:	XP_054949274 ⟸ XM_055093299
- Peptide Label:	isoform X2

Protein Domains

F-box

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000025691	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000028492.1	UniProtKB/TrEMBL
	ENSPPAT00000028509.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1280.50	UniProtKB/TrEMBL
	2.130.10.10	UniProtKB/TrEMBL
InterPro	F-box-like_dom_sf	UniProtKB/TrEMBL
	F-box_dom	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	FBXW4	ENTREZGENE
PANTHER	DACTYLIN	UniProtKB/TrEMBL
	F-BOX/WD REPEAT-CONTAINING PROTEIN 4	UniProtKB/TrEMBL
Pfam	F-box-like	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PROSITE	FBOX	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
	SSF81383	UniProtKB/TrEMBL
UniProt	A0A2R8ZQI8_PANPA	UniProtKB/TrEMBL
	A0A2R8ZQJ8_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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