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ONTOLOGY REPORT - ANNOTATIONS

Term:guanylate cyclase activity
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Accession:GO:0004383 term browser browse the term
Definition:Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
Synonyms:exact_synonym: guanylyl cyclase activity
 narrow_synonym: receptor guanylate cyclase activity
 related_synonym: GTP diphosphate-lyase (cyclizing) activity;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity;   guanyl cyclase activity
 xref: EC:4.6.1.2;   MetaCyc:GUANYLCYC-RXN;   RHEA:13665;   reactome:R-HSA-392152 "Soluble guanylate cyclase converts GTP to cGMP";   reactome:R-HSA-74885 "GUCYs converts GTP to cGMP"


show annotations for term's descendants           Sort by:
guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 enables TAS
ISO
IEA
IBA		 (PMID:23505436)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:23505436 PMID:12441354 GO_REF:0000002 GO_REF:0000033, RGD:628495 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 enables IDA
IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central
RGD		 PMID:11121588 GO_REF:0000002 GO_REF:0000033, RGD:632921 NCBI chr 8:500,212...900,201
Ensembl chr 8:500,212...889,203 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 enables TAS
ISO
IBA		 (PMID:23505436)
GO_REF:0000033		 RGD
GO_Central		 PMID:23505436 PMID:11688978 GO_REF:0000033, RGD:1298936 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 NCBI chr15:36,589,501...36,669,441
Ensembl chr15:36,598,883...36,669,441 		JBrowse link
G Gucy2c guanylate cyclase 2C enables IDA
ISO
IBA		 (PMID:11950846)
GO_REF:0000033
MGI:2665316 (PMID:9294128)		 RGD
GO_Central		 PMID:9294128 PMID:11950846 PMID:1701694 GO_REF:0000033, RGD:728418 NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092 		JBrowse link
G Gucy2d guanylate cyclase 2D enables IDA
IBA		 PMID:11580282
PMID:18178149
PMID:7724600
GO_REF:0000033		 GO_Central PMID:11580282 PMID:18178149 PMID:7724600 GO_REF:0000033, RGD:15023466, RGD:15023485, RGD:68797 NCBI chr 1:152,739,775...152,774,474
Ensembl chr 1:152,739,775...152,774,473 		JBrowse link
G Gucy2e guanylate cyclase 2E enables IDA
ISO
IEA
IBA		 (PMID:21928830), (PMID:30319355)
GO_REF:0000116
GO_REF:0000003
(MGI:5049799|PMID:21598940)
GO_REF:0000033		 RGD
RHEA
UniProt
GO_Central		 PMID:21598940 PMID:21928830 PMID:30319355 PMID:7831337 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 MGI:5049799, RGD:632891 NCBI chr10:53,954,918...53,975,576
Ensembl chr10:53,959,010...53,974,067 		JBrowse link
G Gucy2f guanylate cyclase 2F enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:7831337 GO_REF:0000033, RGD:632891 NCBI chr  X:105,710,356...105,808,183
Ensembl chr  X:105,710,356...105,808,183 		JBrowse link
G Gucy2g guanylate cyclase 2G enables TAS
IEA
IBA		 GO_REF:0000003
GO_REF:0000116
GO_REF:0000033		 UniProt
RHEA
GO_Central
RGD		 PMID:9422765 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:633168 NCBI chr 1:254,237,778...254,280,277
Ensembl chr 1:254,239,174...254,280,277 		JBrowse link
G Npr1 natriuretic peptide receptor 1 enables IDA
ISO
IBA		 (PMID:1672777)
GO_REF:0000033
MGI:2386604 (PMID:11997476), (PMID:16430226)		 RGD
GO_Central		 PMID:1672777 PMID:11997476 PMID:16430226 PMID:1679239 GO_REF:0000033, RGD:729136 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Npr2 natriuretic peptide receptor 2 enables ISO
IEA
IBA		 (PMID:1672777), (PMID:26980729)
GO_REF:0000107
GO_REF:0000033
(PMID:14514678), (PMID:26522847), (PMID:29199951)		 RGD
Ensembl
GO_Central		 PMID:1672777 PMID:14514678 PMID:26522847 PMID:26980729 PMID:29199951 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20487
    catalytic activity 6037
      cyclase activity 24
        guanylate cyclase activity 11
Path 2
Term Annotations click to browse term
  molecular_function 20487
    catalytic activity 6037
      lyase activity 211
        phosphorus-oxygen lyase activity 27
          guanylate cyclase activity 11
paths to the root